Patents by Inventor Mihailo V. Rebec
Mihailo V. Rebec has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230034606Abstract: Methods, systems, and computer readable media are disclosed for estimating an amount of an analyte in blood of a subject. In an example, a method includes obtaining a noise filtered current by noise filtering a current received from an analyte sensor placed interstitially in tissue of the subject, estimating one or more blood analyte calibration parameters based on the noise filtered current, obtaining a second set of one or more interstitial analyte calibration parameters based at least in part on the one or more blood analyte calibration parameters, and estimating the amount of the analyte in the blood of the subject based on the noise filtered current and the one or more interstitial analyte calibration parameters. In this way, an analyte sensor that is placed interstitially may readily be calibrated to report accurate blood analyte values.Type: ApplicationFiled: September 29, 2022Publication date: February 2, 2023Applicant: WaveForm Technologies, Inc.Inventors: Abhinoy Kumar SINGH, Mihailo V. REBEC, Ahmad HAIDAR
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Publication number: 20230027609Abstract: Embodiments provide for methods, systems, apparatus and computer readable media for calibrating an analyte sensor upon insertion into tissue of a subject based at least in part on parameters obtained from another analyte sensor already calibrated and previously inserted into the tissue of the subject. As an example, a method may include predicting a background current associated with the newly inserted sensor, subtracting the background current from a current measured by the newly inserted sensor, and converting the subtracted current to a glucose value, the converting based at least in part on the parameters obtained from the previously inserted analyte sensor. In this way, the newly inserted sensor may be calibrated without relying on actual blood-based analyte measurements, and accuracy and sensitivity of the newly inserted sensor may be improved.Type: ApplicationFiled: September 21, 2022Publication date: January 26, 2023Applicant: WaveForm Technologies, Inc.Inventors: Mihailo V. Rebec, Ralph Dutt-Ballerstadt
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Patent number: 11484227Abstract: A method of in vivo conditioning of an indwelling sensor to reduce run-in time, (stabilization time) comprising: a) applying a first potential to the sensor and measuring a first current at the first potential; b) applying a second potential to the sensor and measuring a second current at the second potential; c) determining a relationship of the first current measured to the second current measured; repeating a, b, and c until the relationship between the first current measured and the second current measured has stabilized, thereby reducing sensor run-in time.Type: GrantFiled: November 1, 2018Date of Patent: November 1, 2022Assignee: WAVEFORM TECHNOLOGIES, INC.Inventors: Mihailo V. Rebec, Robert Bruce, Ralph Dutt-Ballerstadt
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Patent number: 11464433Abstract: Embodiments provide for methods, systems, apparatus and computer readable media for calibrating an analyte sensor upon insertion into tissue of a subject based at least in part on parameters obtained from another analyte sensor already calibrated and previously inserted into the tissue of the subject. As an example, a method may include predicting a background current associated with the newly inserted sensor, subtracting the background current from a current measured by the newly inserted sensor, and converting the subtracted current to a glucose value, the converting based at least in part on the parameters obtained from the previously inserted analyte sensor. In this way, the newly inserted sensor may be calibrated without relying on actual blood-based analyte measurements, and accuracy and sensitivity of the newly inserted sensor may be improved.Type: GrantFiled: May 7, 2020Date of Patent: October 11, 2022Inventors: Mihailo V. Rebec, Ralph Dutt-Ballerstadt
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Publication number: 20210228114Abstract: Systems and methods for operating continuous analyte monitoring (CAM) device are provided. In one example, a method comprises converting a first analyte data stream into analyte values reflective of a biological concentration of the analyte, obtaining one or more additional data streams from one or more adjunctive sensors, inferring based on the first data stream and the one or more additional data streams that conversion of the first data stream into analyte values is predicted to be inaccurate, and taking mitigating action to avoid inaccurate analyte values from being reported to a user. In this way, corrective measures can be taken to improve overall CAM device operation, quality of data provided via a CAM device may be enhanced, and user health and safety profile associated with the continuous analyte monitoring device may be improved.Type: ApplicationFiled: January 22, 2021Publication date: July 29, 2021Applicant: WaveForm Technologies, Inc.Inventors: Mihailo V. REBEC, Hua CAI, Robert BRUCE, Ralph DUTT-BALLERSTADT
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Publication number: 20200383643Abstract: Method, system, and computer readable media are disclosed for estimating an amount of an analyte in blood of a subject. In an example, a method includes obtaining a noise filtered current by noise filtering a current received from an analyte sensor placed interstitially in tissue of the subject, estimating one or more blood analyte calibration parameters based on the noise filtered current, obtaining a second set of one or more interstitial analyte calibration parameters based at least in part on the one or more blood analyte calibration parameters, and estimating the amount of the analyte in the blood of the subject based on the noise filtered current and the one or more interstitial analyte calibration parameters. In this way, an analyte sensor that is placed interstitially may readily be calibrated to report accurate blood analyte values.Type: ApplicationFiled: June 4, 2020Publication date: December 10, 2020Applicant: WaveForm Technologies, Inc.Inventors: Abhinoy Kumar SINGH, Mihailo V. REBEC, Ahmad HAIDAR
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Publication number: 20200352479Abstract: Embodiments provide for methods, systems, apparatus and computer readable media for calibrating an analyte sensor upon insertion into tissue of a subject based at least in part on parameters obtained from another analyte sensor already calibrated and previously inserted into the tissue of the subject. As an example, a method may include predicting a background current associated with the newly inserted sensor, subtracting the background current from a current measured by the newly inserted sensor, and converting the subtracted current to a glucose value, the converting based at least in part on the parameters obtained from the previously inserted analyte sensor. In this way, the newly inserted sensor may be calibrated without relying on actual blood-based analyte measurements, and accuracy and sensitivity of the newly inserted sensor may be improved.Type: ApplicationFiled: May 7, 2020Publication date: November 12, 2020Applicant: WaveForm Technologies, Inc.Inventors: Mihailo V. Rebec, Ralph Dutt-Ballerstadt
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Publication number: 20190125225Abstract: A method of in vivo conditioning of an indwelling sensor to reduce run-in time, (stabilization time) comprising: a) applying a first potential to the sensor and measuring a first current at the first potential; b) applying a second potential to the sensor and measuring a second current at the second potential; c) determining a relationship of the first current measured to the second current measured; repeating a, b, and c until the relationship between the first current measured and the second current measured has stabilized, thereby reducing sensor run-in time.Type: ApplicationFiled: November 1, 2018Publication date: May 2, 2019Applicant: WaveForm Technologies, Inc.Inventors: Mihailo V. Rebec, Robert Bruce, Ralph Dutt-Ballerstadt
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Publication number: 20180242913Abstract: A multi-layer pad that is adapted to be used in determining an analyte concentration is disclosed. The multi-layer pad includes a first layer, a second layer, and a third layer. The first layer includes an enzyme wherein the enzyme is adapted to assist in determining the analyte concentration. The second layer is attached to a first surface of the first layer. The second layer is made of a skin-conforming material. The third layer is attached to a second surface of the first layer wherein the first layer is located between the second layer and the third layer. It is contemplated that the multi-layer pad may also be a two layer system.Type: ApplicationFiled: April 30, 2018Publication date: August 30, 2018Inventors: Boru Zhu, Mihailo V. Rebec, Pamela J. Burson
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Patent number: 10010279Abstract: An electrochemical sensor system is adapted to assist in determining an analyte concentration of a fluid. The electrochemical sensor system comprises a substrate, conductive material and a hydrogel or liquid. The substrate having porosity therethrough. The conductive material includes at least one electrode. The at least one electrode is coupled to the substrate. The at least one electrode has a first surface and an opposing second surface. The hydrogel or liquid is adapted to assist in carrying the analyte of the fluid to the first and second surfaces of the at least one electrode.Type: GrantFiled: April 17, 2017Date of Patent: July 3, 2018Assignee: Ascensia Diabetes Care Holdings AGInventors: Allen J Brenneman, Mihailo V. Rebec
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Patent number: 9993202Abstract: A multi-layer pad that is adapted to be used in determining an analyte concentration is disclosed. The multi-layer pad includes a first layer, a second layer, and a third layer. The first layer includes an enzyme wherein the enzyme is adapted to assist in determining the analyte concentration. The second layer is attached to a first surface of the first layer. The second layer is made of a skin-conforming material. The third layer is attached to a second surface of the first layer wherein the first layer is located between the second layer and the third layer. It is contemplated that the multi-layer pad may also be a two layer system.Type: GrantFiled: May 30, 2007Date of Patent: June 12, 2018Assignee: ASCENSIA DIABETES CARE HOLDINGS AGInventors: Boru Zhu, Mihailo V. Rebec, Pamela J. Burson
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Patent number: 9839360Abstract: An end stage renal disease (ESRD) monitoring system may include an implantable sensor and a reader device with an optical sensor. The implantable sensor may be configured to detect a group of analytes relevant to ESRD, such as glucose, creatinine, urea, and potassium. The implantable sensor may be implanted into the dermis of an animal, and may exhibit color changes in response to the presence of the target analytes or reaction product(s) thereof. The reader device may be configured to capture an image of the implanted sensor and to determine the concentration of the target analytes based at least in part on the image. The reader device may be a personal electronic device such as a cell phone, PDA, or personal computer.Type: GrantFiled: May 10, 2013Date of Patent: December 12, 2017Assignee: Optica, Inc.Inventors: Mihailo V. Rebec, Slavko N. Rebec, Richard G. Sass, Mihailo R. Rebec
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Publication number: 20170273604Abstract: An electrochemical sensor system is adapted to assist in determining an analyte concentration of a fluid. The electrochemical sensor system comprises a substrate, conductive material and a hydrogel or liquid. The substrate having porosity therethrough. The conductive material includes at least one electrode. The at least one electrode is coupled to the substrate. The at least one electrode has a first surface and an opposing second surface. The hydrogel or liquid is adapted to assist in carrying the analyte of the fluid to the first and second surfaces of the at least one electrode.Type: ApplicationFiled: April 17, 2017Publication date: September 28, 2017Inventors: Allen J Brenneman, Mihailo V. Rebec
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Patent number: 9668683Abstract: An electrochemical sensor system is adapted to assist in determining an analyte concentration of a fluid. The electrochemical sensor system comprises a substrate, conductive material and a hydrogel or liquid. The substrate having porosity therethrough. The conductive material includes at least one electrode. The at least one electrode is coupled to the substrate. The at least one electrode has a first surface and an opposing second surface. The hydrogel or liquid is adapted to assist in carrying the analyte of the fluid to the first and second surfaces of the at least one electrode.Type: GrantFiled: December 21, 2006Date of Patent: June 6, 2017Assignee: Ascensia Diabetes Care Holdings AGInventors: Allen J. Brenneman, Mihailo V. Rebec
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Patent number: 9649056Abstract: Embodiments provide sensors, such as implantable sensors, and methods of producing such sensors. An implantable sensor may include a base, one or more chambers, and one or more sensor reagents. A membrane may be coupled to the chambers over the sensor reagents. The implantable sensor may be at least partially implanted into the dermis of an animal. One or more of the sensor reagents may emit light or exhibit a color change in response to the presence of a target analyte or reaction product thereof. The response may be detected and analyzed by the user or by a reader device to determine the target analyte concentration.Type: GrantFiled: December 29, 2012Date of Patent: May 16, 2017Assignee: Optica, Inc.Inventor: Mihailo V. Rebec
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Patent number: 9554735Abstract: A system for determining the concentration of an analyte in at least one body fluid in body tissue comprises an infrared light source, a body tissue interface, a detector, and a central processing unit. The body tissue interface is adapted to contact body tissue and to deliver light from the infrared light source to the contacted body tissue. The detector is adapted to receive spectral information corresponding to infrared light transmitted through the portion of body tissue being analyzed and to convert the received spectral information into an electrical signal indicative of the received spectral information. The central processing unit is adapted to compare the electrical signal to an algorithm built upon correlation with the analyte in body fluid, the algorithm adapted to convert the received spectral information into the concentration of the analyte in at least one body fluid.Type: GrantFiled: April 26, 2013Date of Patent: January 31, 2017Assignee: Ascensia Diabetes Care Holdings AGInventors: Mihailo V. Rebec, James E. Smous, Steven D. Brown, Hu-Wei Tan
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Publication number: 20130303865Abstract: An end stage renal disease (ESRD) monitoring system may include an implantable sensor and a reader device with an optical sensor. The implantable sensor may be configured to detect a group of analytes relevant to ESRD, such as glucose, creatinine, urea, and potassium. The implantable sensor may be implanted into the dermis of an animal, and may exhibit color changes in response to the presence of the target analytes or reaction product(s) thereof. The reader device may be configured to capture an image of the implanted sensor and to determine the concentration of the target analytes based at least in part on the image. The reader device may be a personal electronic device such as a cell phone, PDA, or personal computer.Type: ApplicationFiled: May 10, 2013Publication date: November 14, 2013Applicant: BioMetric Holdings, Inc.Inventors: Mihailo V. Rebec, Slavko N. Rebec, Richard G. Sass, Mihailo R. Rebec
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Publication number: 20130303869Abstract: A mobile analyte monitoring system may include an implantable sensor and a reader device with an optical sensor. The implantable sensor may be implanted into the dermis of an animal, and may exhibit a color change in response to the presence of a target analyte or reaction product thereof. The reader device may be configured to capture an image of the implanted sensor and to determine the concentration of the target analyte based at least in part on the image. One or more portions of the implantable sensor or components thereof may be configured to facilitate calibration of the sensor, correction of an optical signal obtained from the sensor by a reader device to accommodate variations in the surrounding tissues, and/or calculation of a representative value by a reader device. The reader device may be a personal electronic device such as a cell phone, PDA, or personal computer.Type: ApplicationFiled: May 10, 2013Publication date: November 14, 2013Applicant: WellSense Inc.Inventors: Mihailo V. Rebec, Slavko N. Rebec, Richard G. Sass
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Publication number: 20130261406Abstract: A system for determining the concentration of an analyte in at least one body fluid in body tissue comprises an infrared light source, a body tissue interface, a detector, and a central processing unit. The body tissue interface is adapted to contact body tissue and to deliver light from the infrared light source to the contacted body tissue. The detector is adapted to receive spectral information corresponding to infrared light transmitted through the portion of body tissue being analyzed and to convert the received spectral information into an electrical signal indicative of the received spectral information. The central processing unit is adapted to compare the electrical signal to an algorithm built upon correlation with the analyte in body fluid, the algorithm adapted to convert the received spectral information into the concentration of the analyte in at least one body fluid.Type: ApplicationFiled: April 26, 2013Publication date: October 3, 2013Applicant: Bayer HealthCare LLCInventors: Mihailo V. Rebec, James E. Smous, Steven D. Brown, Hu-Wei Tan
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Publication number: 20130217983Abstract: Embodiments provide analyte sensors, such as implantable analyte sensors, and methods of producing the same. An implantable sensor may include a base with a plurality of chambers. One or more sensor reagents may be retained within the chambers to form analysis regions. A membrane may be coupled to the chambers over the sensor reagents. The implantable sensor may be implanted into the dermis of a subject. One or more of the sensor reagents may exhibit a color change in response to the presence of a target analyte or reaction product thereof. The wavelengths of light reflected from the analysis regions may be detected and analyzed to determine a target analyte concentration. One or more portions of the sensor or components thereof may be configured to facilitate calibration of the sensor, correction of an optical signal obtained from the sensor by a reader device to accommodate variations in the surrounding tissues, and/or calculation of a representative value by a reader device.Type: ApplicationFiled: December 29, 2012Publication date: August 22, 2013Applicant: WELLSENSE, INC.Inventors: Mihailo V. Rebec, Slavko N. Rebec, Richard G. Sass