Patents by Inventor Mihaly Garamvolgyi

Mihaly Garamvolgyi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of vancomycin
    Patent number: 5223413
    Abstract: The invention relates to a process for preparation of the vancomycin antibiotic in a microbiological way by aerobic fermentation, by using a strain belonging to the Micropolyspora species in a culture-medium containing assimilable carbon and nitrogen sources as well as mineral salts. According to the invention as microorganisms the aminoglycoside-resistant NCAIM 001092 and NCAIM 001093 mutants of the strain belonging to the Micropolyspora orientalis species are used. Nitrates are suitable mineral salts in the fermentation. Soy flour, glycerol, calcium gluconate, starch are useful carbon sources. The fermentation is carried out preferably at a temperature of 29.degree.-30.degree. C. The vancomycin antibiotic produced in the fermentation is separated by using reverse osmosis and ultrafiltration following ion-exchange chromatography.
    Type: Grant
    Filed: September 26, 1991
    Date of Patent: June 29, 1993
    Assignee: Biochin Biotechnologial Leanyvallalat
    Inventors: Mariann Nagy, Miklos Jarai, Istvan Financsek, Ilona Varga, Geza Kocsis, Viola Muri, Andrasi Andras, Laszlo Kegl, Gabriella Zlatos, Marta Szoke nee Zlatos, Endre Kollar, A/ gnes Udvardy, Mihaly Garamvolgyi