Patents by Inventor Mihir Metkar

Mihir Metkar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • POLYNUCLEOTIDES ENCODING FANCONI ANEMIA, COMPLEMENTATION GROUP PROTEINS FOR THE TREATMENT OF FANCONI ANEMIA
    Publication number: 20250221931
    Abstract: This disclosure relates to mRNA therapy for the treatment of Fanconi anemia and related diseases, disorders or conditions. mRNAs for use in the invention, when administered in vivo, encode a Fanconi anemia, complementation group (FANC) protein such as FANCA, FANCC, or FANCG. mRNA therapies of the disclosure increase and/or restore deficient levels of a FANC protein such as FANCA, FANCC, or FANCG expression and/or activity in subjects.
    Type: Application
    Filed: March 24, 2023
    Publication date: July 10, 2025
    Inventors: Meghan Brundage, Jonathan Hoggatt, Youmna Kfoury, Mihir Metkar, David Reid
  • POLYNUCLEOTIDES ENCODING RELAXIN FOR THE TREATMENT OF FIBROSIS AND/OR CARDIOVASCULAR DISEASE
    Publication number: 20250017867
    Abstract: This disclosure relates to mRNA therapy for the treatment of relaxin-related diseases, disorders or conditions such as, e.g., fibrosis or cardiovascular disease (e.g., acute heart failure or acute coronary syndrome). mRNAs for use in the invention, when administered in vivo, encode relaxin. mRNA therapies of the disclosure increase and/or restore deficient levels of relaxin expression and/or activity in subjects.
    Type: Application
    Filed: September 30, 2022
    Publication date: January 16, 2025
    Inventors: Michael Albert Zimmer, Xinhua Yan, Mihir Metkar, David Reid
  • ENGINEERED POLYNUCLEOTIDES FOR CELL-TYPE OR MICROENVIRONMENT-SPECIFIC EXPRESSION
    Publication number: 20240384277
    Abstract: The disclosure features compositions or systems and uses thereof, comprising a first polynucleotide encoding a target molecule, optionally a second polynucleotide encoding an effector, repressor, or endonuclease molecule; optionally a recognition or cleavage site in the first or second polynucleotide, and optionally a repressor/effector binding site in the first polynucleotide. The compositions or systems of the present disclosure can increase the level and/or activity of the target molecule in desired cells and/or microenvironments while suppressing the level and/or activity of the target molecule in off-target cells and/or microenvironments.
    Type: Application
    Filed: June 14, 2022
    Publication date: November 21, 2024
    Inventors: Ruchi Jain, Brian Robert Fritz, Mihir Metkar
  • MULTI-PROLINE-SUBSTITUTED CORONAVIRUS SPIKE PROTEIN VACCINES
    Publication number: 20230355743
    Abstract: The disclosure provides coronavirus ribonucleic acid (RNA) vaccines as well as methods of using the vaccines and compositions comprising the vaccines.
    Type: Application
    Filed: September 24, 2021
    Publication date: November 9, 2023
    Applicant: ModernaTX, Inc.
    Inventors: Guillaume Stewart-Jones, Mihir Metkar, Vladimir Presnyak
  • SARS-COV-2 MRNA DOMAIN VACCINES
    Publication number: 20230346914
    Abstract: The disclosure relates to coronavirus ribonucleic acid (RNA) vaccines as well as methods of using the vaccines and compositions comprising the vaccines. The RNA vaccines encode domains and subunits of coronavirus.
    Type: Application
    Filed: February 6, 2021
    Publication date: November 2, 2023
    Applicant: ModernaTX, Inc.
    Inventors: Guillaume Stewart-Jones, Andrea Carfi, Sayda Mahgoub Elbashir, Mihir Metkar
  • CORONAVIRUS RNA VACCINES
    Publication number: 20230108894
    Abstract: The disclosure relates to coronavirus ribonucleic acid (RNA) vaccines as well as methods of using the vaccines and compositions comprising the vaccines.
    Type: Application
    Filed: January 26, 2021
    Publication date: April 6, 2023
    Applicant: Moderna TX, Inc
    Inventors: Guillaume Stewart-Jones, Elisabeth Narayanan, Hamilton Bennett, Andrea Carfi, Mihir Metkar, Vladimir Presnyak
  • CORONAVIRUS RNA VACCINES
    Publication number: 20220323572
    Abstract: The disclosure relates to coronavirus ribonucleic acid (RNA) vaccines as well as methods of using the vaccines and compositions comprising the vaccines.
    Type: Application
    Filed: November 3, 2021
    Publication date: October 13, 2022
    Applicant: ModernaTX, Inc.
    Inventors: Mihir Metkar, Valdimir Presnyak
  • CORONAVIRUS RNA VACCINES
    Publication number: 20210228707
    Abstract: The disclosure relates to coronavirus ribonucleic acid (RNA) vaccines as well as methods of using the vaccines and compositions comprising the vaccines.
    Type: Application
    Filed: August 21, 2020
    Publication date: July 29, 2021
    Applicant: ModernaTX, Inc.
    Inventors: Mihir Metkar, Vladimir Presnyak, Guillaume Stewart-Jones