Abstract: To provide an agent that increases expression of genes contributing to hair growth in dermal papilla cells, a scalp care agent, and a hair growth agent which are topical agents that exhibit effect in terms of causing increase in hair shaft diameter and improving maximum hair shaft length and improving hair shaft elongation rate and new hair growth and increasing expression of genes contributing to hair growth in dermal papilla cells and promoting hair shaft growth at head hair, beard, eyelashes, and/or eyebrows, such agents are made to contain an active ingredient in the form of palmitoyl dipeptide-5 diaminobutyloyl hydroxythreonine.

Abstract: To provide an agent that increases expression of genes contributing to hair growth in dermal papilla cells, a scalp care agent, and a hair growth agent which are topical agents that exhibit effect in terms of causing increase in hair shaft diameter, and improving maximum hair shaft length, and improving hair shaft elongation rate, and new hair growth and increasing expression of genes contributing to hair growth in dermal papilla cells, and promoting hair shaft growth at head hair, beard, eyelashes, and/or eyebrows, such agents are made to contain an active ingredient in the form of palmitoyl dipeptide-5 diaminohydroxybutyrate.

Abstract: To provide a hair growth agent which is a topical agent that exhibits effect in terms of causing increase in hair shaft diameter and improving maximum hair shaft length and improving hair shaft elongation rate and new hair growth and increasing expression of genes contributing to hair growth in dermal papilla cells and promoting hair shaft growth at head hair, eyelashes, and/or eyebrows, a hair growth agent which is a topical agent is made to contain active ingredients in the form of palmitoyl dipeptide-5 diaminobutyloyl hydroxythreonine and palmitoyl dipeptide-5 diaminohydroxybutyrate.

Abstract: A culture container (1) having a guide thread (31) and a plurality of cells (32) that is capable of culturing a regenerative hair follicle germ (30), wherein the culture container (1) is equipped with a first recess (10) and a second recess (20) and the second recess (20) has a second bottom (22) where the guide thread (31) can be positioned in the center of an opening (23) and a method for producing a regenerative hair follicle germ that includes a step for aggregating a cell population including epithelial cells (32a) within the second recess (20) of the culture container (1), a step for aggregating a cell population including mesenchymal cells (32b) within the second recess (20), a step for inserting the guide thread (31) into the second recess (20), and a step for culturing the cell population including epithelial cells (32a) and the mesenchymal cells (32b).

Abstract: To provide means for efficient growth of epithelial cells capable of being used to manufacture regenerated hair follicle germs. Provided are a culture medium for growth of epithelial cells capable of being used to manufacture regenerated hair follicle germs, the culture medium comprising basal medium and at least (1) through (3), below: and a method for growing the epithelial cells using the culture medium: (1) at least one species of BMP inhibitor: (2) at least one species of fibroblast growth factor: and (3) at least one species of sonic hedgehog (SHH) and/or SHH agonist.

Abstract: The present invention provides a dental implant device comprising a dental implant body and an implant fixture. Said implant fixture is characterized in that it comprises a portion to be fixed to said implant body and a portion to be fixed to a tooth adjacent to the transplantation site of said implant body in a subject, and is configured so that mechanical stimulation from the tooth adjacent to said transplantation site is transmissible to said implant body, and said implant device is characterized in that it is placed into the oral cavity of said subject so that said implant body is inserted at said transplantation site while said implant fixture is fixed to said implant body and the tooth adjacent to said transplantation site.

Abstract: The object of the present invention is to provide an artificial skin having hair follicles, sebaceous glands, and hair pores. The present invention provides a method for manufacturing artificial skin having hair follicles, sebaceous glands, and hair pores, characterized in that it comprises each of the following steps: (A): a step of preparing an artificial skin having dermal and epidermal layers or an artificial skin having only a dermal layer; and (B): a step of transplanting isolated hair follicles to the artificial skin prepared in step (A); wherein said isolated hair follicle comprises a sebaceous gland, and said isolated hair follicle is transplanted to said artificial skin so that the surface of said dermal Layer of said artificial skin is in alignment with the position of the hair pore portion of said isolated hair follicle.