Patents by Inventor Mihriban Tuna

Mihriban Tuna has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BISPECIFIC ANTIBODY FOR ICOS AND PD-L1
    Publication number: 20200407446
    Abstract: Multispecific antibody in mAb2 format, comprising an ICOS-binding Fab region and a PD-L1-binding Fcab region. Use of the multispecific antibody in immuno-oncology, including for treatment of solid tumours. Combination therapy including antibody to another immune checkpoint molecule such as PD-1 and CTLA-4, in addition to anti-ICOS and anti-PD-L1.
    Type: Application
    Filed: December 19, 2018
    Publication date: December 31, 2020
    Inventors: Matthew John MCCOURT, Richard Charles Alfred SAINSON, Jamie Iain CAMPBELL, Stephen John ARKINSTALL, Mihriban TUNA, Ryan FIEHLER, Mustapha FAROUDI, Fadi BADR, Francisca WOLLERTON VAN HORCK, Frederik AKELE
  • CONDITIONAL AGONISTS OF IMMUNE RESPONSES
    Publication number: 20190338049
    Abstract: The application relates to antibody molecules, which bind to a first and second antigen, the first antigen being a disease antigen, for example a tumour antigen, and the second antigen being a tumour necrosis factor receptor superfamily (TNFRSF) receptor antigen on the surface of an immune cell. The antibody molecules preferably comprise a CDR-based antigen-binding site and an antigen-binding site, which may be located in two or more structural loops of a constant domain of the antibody molecule. The antibody molecules find application, for example, in cancer therapy.
    Type: Application
    Filed: January 9, 2018
    Publication date: November 7, 2019
    Applicant: F-star Beta Limited
    Inventors: Mihriban Tuna, John Soerensen Haurum, Jacqueline Francoise Doody, Haijun Sun, Miguel Gaspar
  • LAG-3 BINDING MEMBERS
    Publication number: 20190330344
    Abstract: The present invention relates to specific binding members which bind to lymphocyte-activation gene 3 (LAG-3). The specific binding members preferably comprise a LAG-3 antigen-binding site which may be located in two or more structural loops of a CH3 domain of the specific binding member. The specific binding members of the invention find application, for example, in cancer therapy.
    Type: Application
    Filed: June 20, 2017
    Publication date: October 31, 2019
    Applicant: F-STAR BETA LIMITED
    Inventors: Mihriban Tuna, Francisca Wollerton Van Horck, Katy Louise Everett, Miguel Gaspar, Matthew Kraman, Katarzyna Kmiecik, Natalie Fosh
  • BINDING MOLECULES BINDING PD-L1 AND LAG-3
    Publication number: 20190256602
    Abstract: The present invention relates to antibody molecules which bind to programmed death-ligand 1 (PD-L1) and lymphocyte-activation gene 3 (LAG-3). The antibody molecules preferably comprise a CDR-based antigen binding site for PD-L1, and a LAG-3 antigen binding site which may be located in two or more structural loops of a CH3 domain of the antibody molecule. The antibody molecules of the invention find application, for example, in cancer therapy.
    Type: Application
    Filed: June 20, 2017
    Publication date: August 22, 2019
    Applicant: F-STAR DELTA LIMITED
    Inventors: Jamie Campbell, Nikole Sandy, Mihriban Tuna, Francisca Wollerton Van Horck, Katy Louise Everett, Miguel Gaspar, Matthew Kraman, Katarzyna Kmiecik, Mustapha Faroudi, Natalie Fosh, Barbara Hebeis
  • EGFR BINDING MOLECULES
    Publication number: 20190202920
    Abstract: The application relates to specific binding members which bind the human epidermal growth factor receptor (EGFR). The specific binding members preferably comprise an EGFR antigen-binding site which may be located in two or more structural loops of a CH3 domain of the specific binding member. The specific binding members are expected to find application in the treatment of cancers expressing EGFR.
    Type: Application
    Filed: July 19, 2017
    Publication date: July 4, 2019
    Applicant: F-STAR BETA LIMITED
    Inventors: Mihriban TUNA, Kin-Mei LEUNG, Haijun SUN, Melanie MEDCALF, Samine ISAAC
  • DUAL-SPECIFIC IL-1A/ IL-1B ANTIBODIES
    Publication number: 20130171146
    Abstract: The invention provides an isolated, dual-specific antibody, or an antigen-binding portion thereof, which is specific for human IL-1? and human IL-1?. The dual specific antibodies of the invention also neutralize both human IL-1? and human IL-1?. The invention also provides domain antibodies (dAbs) specific for human IL-1? and human IL-1?.
    Type: Application
    Filed: August 21, 2012
    Publication date: July 4, 2013
    Applicant: ABBOTT LABORATORIES
    Inventors: Chung-ming Hsieh, Bradford L. McRae, Yuliya Kutskova, John E. Memmott, Michael Roguska, Ian Tomlinson, Carrie Enever, Steven Grant, Mihriban Tuna
  • Dual-specific IL-1?/IL-1? antibodies
    Patent number: 8324350
    Abstract: The invention provides an isolated, dual-specific antibody, or an antigen-binding portion thereof, which is specific for human IL-1? and human IL-1?. The dual specific antibodies of the invention also neutralize both human IL-1? and human IL-1?. The invention also provides domain antibodies (dAbs) specific for human IL-1? and human IL-1?.
    Type: Grant
    Filed: December 28, 2007
    Date of Patent: December 4, 2012
    Assignee: Abbott Laboratories
    Inventors: Chung-ming Hsieh, Bradford L. McRae, Yuliya Kutskova, John E. Memmott, Michael Roguska, Ian Tomlinson, Carrie Enever, Steven Grant, Mihriban Tuna
  • Dual-specific IL-1A/IL-1b antibodies
    Publication number: 20090291081
    Abstract: The invention provides an isolated, dual-specific antibody, or an antigen-binding portion thereof, which is specific for human IL-1? and human IL-1?. The dual specific antibodies of the invention also neutralize both human IL-1? and human IL-1?. The invention also provides domain antibodies (dAbs) specific for human IL-1? and human IL-1?.
    Type: Application
    Filed: December 28, 2007
    Publication date: November 26, 2009
    Inventors: Chung-Ming Hsieh, Bradford L. McRae, Yuliya Kutskova, John E. Memmott, Michael Roguska, Ian Tomlinson, Carrie Enever, Steven Grant, Mihriban Tuna