Abstract: Provided are a beam splitter using a multiple refractive index layer, which enables high magnification measurement by transmitting infrared light and reflecting visible light, and a defective element detection device including the same. The beam splitter includes a multiple refractive index layer and a base layer. The multiple refractive index layer is configured to reflect first light and transmit second light having a wavelength longer than a wavelength of the first light. The base layer is provided on one side of the multiple refractive index layer and configured to transmit the second light transmitted through the multiple refractive index layer. The multiple refractive index layer includes a first refractive index layer having a first refractive index and a second refractive index layer having a second refractive index less than the first refractive index.

Abstract: The present disclosure provides: a compound of a specific chemical structure, having excellent activity with respect to BTK degradation; or a pharmaceutically acceptable salt thereof. The present disclosure also provides a composition comprising the compound or pharmaceutically acceptable salts thereof. The present disclosure also provides are pharmaceutical use for treating or preventing BTK-associated diseases (for example, autoimmune diseases or cancer) of the compound, the salt thereof, and the composition comprising same according to the present disclosure. The present disclosure also provides a method for treating or preventing BTK-associated diseases (for example, autoimmune diseases or cancer), comprising administering, to a subject requiring treatment, an effective amount of the compound, the salt thereof, or the composition comprising same according to the present disclosure.

Abstract: The present invention relates to optimization logic for preparing an optimal combination of oligonucleotides hybridized with a plurality of target nucleic acid sequences, in a completely different approach from conventional methods, i.e., empirical and manual methods. In addition, the optimization logic of the present invention may be used to (i) preparing an oligonucleotide combination used to detect a plurality of target nucleic acid sequences with a target coverage of interest, (ii) selecting target nucleic acid sequences to be detected by a multiplex target detection with a highest target coverage by using a limited number of oligonucleotides, and (iii) determining a conserved region in a plurality of target nucleic acid sequences.

Abstract: The present invention relates to optimization logic for preparing an optimal combination of oligonucleotides hybridized with a plurality of target nucleic acid sequences, in a completely different approach from conventional methods, i.e., empirical and manual methods. In addition, the optimization logic of the present invention may be used to (i) preparing an oligonucleotide combination used to detect a plurality of target nucleic acid sequences with a target coverage of interest, (ii) selecting target nucleic acid sequences to be detected by a multiplex target detection with a highest target coverage by using a limited number of oligonucleotides, and (iii) determining a conserved region in a plurality of target nucleic acid sequences.

Abstract: The present invention relates to optimization logic for preparing an optimal introduction of degenerate bases and/or universal bases into an oligonucleotide used to detect a plurality of target nucleic acid sequences, in a completely different approach from conventional methods, i.e., empirical and manual methods. In addition, the optimization logic of the present invention may be used in (i) the preparation of an oligonucleotide into which a limited number of degenerate bases and/or universal bases are introduced for detecting a plurality of target nucleic acid sequences with a maximum target coverage, and (ii) the determination of a probing region in a plurality of target nucleic acid sequences.

Abstract: Embodiments disclosed herein include a method for use with a semiconductor processing tool. In an embodiment, the method comprises configuring the semiconductor processing tool, running a benchmark test on the semiconductor processing tool, providing hardware operating window (HOW) analytics, generating a design of experiment (DoE) using the HOW analytics, implementing process optimization, and releasing an iteration of the process recipe. In an embodiment, the method further comprises margin testing the iteration of the process recipe.

Abstract: The present invention relates to a method for de-tecting an abnormal signal using two or more datasets. The present invention makes it possible to detect abnormal signals based on characteristics of abnormal signals commonly occurring in two or more datasets, which is effectively applied to datasets obtained by a multiplex PCR method.

Abstract: The present invention relates to a method for predicting the melting temperature (Tm) of an oligonucleotide, in particular a primer or probe, in a PCR or hybridization assay. The method of present invention can accurately predict the Tm of an oligonucleotide in various reaction environments using the equations for Tm calculation, the equation including parameter values optimized for the reaction environment in which the oligonucleotide is to be used.

Abstract: The present invention relates to optimization logic for preparing an optimal introduction of degenerate bases and/or universal bases into an oligonucleotide used to detect a plurality of target nucleic acid sequences, in a completely different approach from conventional methods, i.e., empirical and manual methods. In addition, the optimization logic of the present invention may be used in (i) the preparation of an oligonucleotide into which a limited number of degenerate bases and/or universal bases are introduced for detecting a plurality of target nucleic acid sequences with a maximum target coverage, and (ii) the determination of a probing region in a plurality of target nucleic acid sequences.

Abstract: The present invention relates to optimization logic for preparing an optimal combination of oligonucleotides hybridized with a plurality of target nucleic acid sequences, in a completely different approach from conventional methods, i.e., empirical and manual methods. In addition, the optimization logic of the present invention may be used to (i) preparing an oligonucleotide combination used to detect a plurality of target nucleic acid sequences with a target coverage of interest, (ii) selecting target nucleic acid sequences to be detected by a multiplex target detection with a highest target coverage by using a limited number of oligonucleotides, and (iii) determining a conserved region in a plurality of target nucleic acid sequences.

Abstract: The present invention relates to a method for detecting an abnormal signal using two or more datasets. The present invention makes it possible to detect abnormal signals based on characteristics of abnormal signals commonly occurring in two or more datasets, which is effectively applied to datasets obtained by a multiplex PCR method.

Abstract: The present invention relates to a composition for cosmetic raw material containing cellulose dyed with a natural coloring matter having improved photostability, and a visual carrier system comprising the same. In the composition for cosmetic raw material and the visual carrier system comprising the same according to the present invention, by using no iron oxide chemical coloring matter and applying a typical and natural dyeing method of cloths to the microcrystalline cellulose that is the cosmetic raw material, photostability that is a problem of the natural coloring matter in the related art is largely improved.

Abstract: The present invention relates to a composition for cosmetic raw material containing cellulose dyed with a natural coloring matter having improved photostability, and a visual carrier system comprising the same. In the composition for cosmetic raw material and the visual carrier system comprising the same according to the present invention, by using no iron oxide chemical coloring matter and applying a typical and natural dyeing method of cloths to the microcrystalline cellulose that is the cosmetic raw material, photostability that is a problem of the natural coloring matter in the related art is largely improved.