Patents by Inventor Mika Endoh

Mika Endoh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified antibody constant regions
    Patent number: 10150808
    Abstract: The present inventors successfully provided constant regions capable of enhancing the agonist activity of antibodies through amino acid sequence alterations. Specifically, agonist activity was found to be enhanced in antibodies having a constant region in which amino acids of the antibody heavy chain constant region are substituted or deleted, or antibodies having a constant region in which the hinge region amino acids are substituted. Use of such antibodies as pharmaceutical formulations can provide pharmaceutical formulations with improved performance.
    Type: Grant
    Filed: September 24, 2010
    Date of Patent: December 11, 2018
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Taichi Kuramochi, Shigero Tanba, Tomoyuki Igawa, Atsuhiko Maeda, Kiyoaki Sakata, Mika Endoh
  • Modified Antibody Constant Regions
    Publication number: 20120238729
    Abstract: The present inventors successfully provided constant regions capable of enhancing the agonist activity of antibodies through amino acid sequence alterations. Specifically, agonist activity was found to be enhanced in antibodies having a constant region in which amino acids of the antibody heavy chain constant region are substituted or deleted, or antibodies having a constant region in which the hinge region amino acids are substituted. Use of such antibodies as pharmaceutical formulations can provide pharmaceutical formulations with improved performance.
    Type: Application
    Filed: September 24, 2010
    Publication date: September 20, 2012
    Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHA
    Inventors: Taichi Kuramochi, Shigero Tanba, Tomoyuki Igawa, Atsuhiko Maeda, Kiyoaki Sakata, Mika Endoh