Abstract: The present application provides a novel means for treating ornithine transcarbamylase deficiency. More specifically, the present application provides a modified adeno-associated virus vector which expresses ornithine transcarbamylase so that an attack from a neutralizing antibody in blood is reduced and a gene is efficiently introduced into a liver of a living body (for example, human). The present application provides, for example, a modified adeno-associated virus vector which expresses omithine transcarbamylase, which contains a modified VP1 protein that contains, for example, an amino acid sequence obtained by substituting at least one of the amino acids at positions 472, 587 and 706 in the amino acid sequence of the VP1 protein with another amino acid, and which does not cross-react with a neutralizing antibody against AAV2.

Abstract: A two-dimensional region of interest is set within a liver of a subject (S12). A first parameter group including a first attenuation coefficient is calculated based on first reception information obtained from the two-dimensional region of interest (S16). A second parameter group including a second attenuation coefficient is calculated based on second reception information obtained from the two-dimensional region of interest (S20). A parameter set including the first parameter group and the second parameter group is given to a mathematical model to calculate an estimated value of a fat fraction (S22).

Abstract: The present invention relates to a composition for gene transfer comprising a recombinant virus vector and provides a composition for gene transfer which improves the efficiency of gene transfer using a virus vector. Specifically, the present invention provides a composition for gene transfer, which comprises a recombinant virus vector comprising a gene of interest for expression and a sugar at a concentration of at least 40 mM. The virus vector is preferably an adeno-associated virus vector. By using the composition of the present invention, the efficiency of gene transfer using a virus vector can be improved by about 50 times or more.

Abstract: The present application provides a modified adeno-associated virus (AAV) vector that efficiently transfers genes to a liver in a living body (human, for example) by reducing the attack from neutralizing antibodies in blood. More specifically, the present application provides an adeno-associated virus vector comprising a capsid protein having an amino acid sequence which has at least one of serine at position 472, serine at position 587, and asparagine at position 706 in the amino acid sequence represented by SEQ ID NO: 2 or 3 substituted with another amino acid, and has 1 to 6 amino acid residues at other residue positions deleted, substituted or inserted. Said adeno-associated virus vector does not cross-react with a neutralizing antibody against AAV serotype 2 (AAV2).

Abstract: The present invention relates to a composition for gene transfer comprising a recombinant virus vector and provides a composition for gene transfer which improves the efficiency of gene transfer using a virus vector. Specifically, the present invention provides a composition for gene transfer, which comprises a recombinant virus vector comprising a gene of interest for expression and a sugar at a concentration of at least 40 mM. The virus vector is preferably an adeno-associated virus vector. By using the composition of the present invention, the efficiency of gene transfer using a virus vector can be improved by about 50 times or more.

Abstract: A headset includes: a microphone, a first transmission line that transmits a first electrical signal generated by the microphone to an external device; an operation switch that receives an operation for switching between (i) a non-mute state in which the first electrical signal is transmitted to the external device and (ii) a mute state in which the first electrical signal is not transmitted to the external device; an electronic switch that switches between (i) a conductive state in which the first electrical signal is transmitted and (ii) a non-conductive state in which the first electrical signal is not transmitted, on the basis of a control voltage which changes according to the state of the operation switch; and a voltage generator that generates the control voltage.

Abstract: A headset includes: a microphone, a first transmission line that transmits a first electrical signal generated by the microphone to an external device; an operation switch that receives an operation for switching between (i) a non-mute state in which the first electrical signal is transmitted to the external device and (ii) a mute state in which the first electrical signal is not transmitted to the external device; an electronic switch that switches between (i) a conductive state in which the first electrical signal is transmitted and (ii) a non-conductive state in which the first electrical signal is not transmitted, on the basis of a control voltage which changes according to the state of the operation switch; and a voltage generator that generates the control voltage.

Abstract: Provided are a fluorescent on/off switchable compound for a gene analysis, which is highly stable and highly sensitive, and enables amplification and observation of a trace gene signal, and a labeling reagent for detection of a bio-related material, which uses the fluorescent on/off switchable compound. A compound represented by the following formula (I?): wherein X is a hydrogen atom or a carboxylic acid-protecting group, Y is a 2,4-dinitrobenzenesulfonyl group, a 2-cyano-4-nitrobenzenesulfonyl group or a 5-nitropyridin-2-ylsulfonyl group, R1, R2, R3 and R4 are each independently a hydrogen atom, a halogen atom, a hydroxyl group, an alkyl group having a carbon number of 1 to 6, an alkoxy group having a carbon number of 1 to 6, an aryl group having a carbon number of 6 to 10, or a cyano group.

Abstract: Provided are a fluorescent on/off switchable compound for a gene analysis, which is highly stable and highly sensitive, and enables amplification and observation of a trace gene signal, and a labeling reagent for detection of a bio-related material, which uses the fluorescent on/off switchable compound. A compound represented by the following formula (I?): wherein X is a hydrogen atom or a carboxylic acid-protecting group, Y is a 2,4-dinitrobenzenesulfonyl group, a 2-cyano-4-nitrobenzenesulfonyl group or a 5-nitropyridin-2-ylsulfonyl group, R1, R2, R3 and R4 are each independently a hydrogen atom, a halogen atom, a hydroxyl group, an alkyl group having a carbon number of 1 to 6, an alkoxy group having a carbon number of 1 to 6, an aryl group having a carbon number of 6 to 10, or a cyano group.

Abstract: It is an object of the present invention to provide: a novel thiol-detecting reagent, which can be used in vivo and which solves the problem regarding the generation of background fluorescence due to hydrolysis; and a method for detecting thiol using the aforementioned reagent. The present invention provides a compound represented by the following formula (1): wherein each R2 independently represents an alkyl group containing 1 to 6 carbon atoms, a halogen atom, or a hydrogen atom.

Abstract: A seat which can obtain a favorable sitting feeling using a fibrous structure is provided. A seat 1 is provided with a cushion body 11 comprising fibrous structures 4a to 4d and a seat frame 15 supporting the cushion body 11, in which the fibrous structures 4a to 4d are formed by stacking a web 2 so that the web 2 extends along a thickness direction T of the fibrous structures, the cushion body 11 is formed so that the thickness direction T of the fibrous structure 4a is along a load direction applied on the cushion body 11 at sitting, and a stacking direction of the web 2 constituting the fibrous structure 4a is along a widthwise direction W of the cushion body 11.

Abstract: A cushion body which has a force to support a large load and both a soft touch feeling and can maintain an undulation shape of a groove portion and the like provided on a contact surface with a seat occupant favorable, a seat using the same, and a manufacturing method thereof are provided.

Abstract: It is an object of the present invention to provide: a novel thiol-detecting reagent, which can be used in vivo and which solves the problem regarding the generation of background fluorescence due to hydrolysis; and a method for detecting thiol using the aforementioned reagent. The present invention provides a compound represented by the following formula (1): wherein each R2 independently represents an alkyl group containing 1 to 6 carbon atoms, a halogen atom, or a hydrogen atom.

Abstract: A cushion body 11 is formed by stacking a first sheet-like fibrous structure 4a and a second sheet-like fibrous structure 4b where webs 2 are stacked such that their extending direction conforms with a thickness direction T of the cushion body and between the first sheet-like fibrous structure 4a and the second sheet-like fibrous structure 4b, a load receiving member 4e whose flexing degree to load in the thickness direction T is small is disposed.

Abstract: A cushion body 11 is formed by stacking a first sheet-like fibrous structure 4a and a second sheet-like fibrous structure 4b where webs 2 are stacked such that their extending direction conforms with a thickness direction T of the cushion body and between the first sheet-like fibrous structure 4a and the second sheet-like fibrous structure 4b, a load receiving member 4e whose flexing degree to load in the thickness direction T is small is disposed.

Abstract: The present invention provides an anti-diacetylspermine specific monoclonal antibody which satisfies a specific measuring condition in an immunoreaction system between a solid-phased diacetylspermine and the anti-diacetylspermine specific monoclonal antibody, wherein the immunoreaction system comprises a sample diacetylspermine or sample N1-acetylspermidine to inhibit the immunoreaction; and the specific measuring condition is that the 50% inhibition activity against the immunoreaction by the diacetylspermine in the sample is at least 1,000 times as much as the 50% inhibition activity against the immunoreaction by the N1-acetylspermidine in the sample.

Abstract: The present invention provides an anti-diacetylspermine specific monoclonal antibody which satisfies a specific measuring condition in an immunoreaction system between a solid-phased diacetylspermine and the anti-diacetylspermine specific monoclonal antibody, wherein the immunoreaction system comprises a sample diacetylspermine or sample N1-acetylspermidine to inhibit the immunoreaction; and the specific measuring condition is that the 50% inhibition activity against the immunoreaction by the diacetylspermine in the sample is at least 1,000 times as much as the 50% inhibition activity against the immunoreaction by the N1-acetylspermidine in the sample.

Abstract: A seat which can obtain a favorable sitting feeling using a fibrous structure is provided. A seat 1 is provided with a cushion body 11 comprising fibrous structures 4a to 4d and a seat frame 15 supporting the cushion body 11, in which the fibrous structures 4a to 4d are formed by stacking a web 2 so that the web 2 extends along a thickness direction T of the fibrous structures, the cushion body 11 is formed so that the thickness direction T of the fibrous structure 4a is along a load direction applied on the cushion body 11 at sitting, and a stacking direction of the web 2 constituting the fibrous structure 4a is along a widthwise direction W of the cushion body 11.

Abstract: A cushion body, which can secure both a soft touch feeling and favorable shape reproduction of a groove portion, a seat having the same, and a manufacturing method thereof are provided. A cushion body 11 is formed by stacking a plurality of sheet-like fibrous structures 4a to 4e, a groove portion 12 is formed in a surface layer, and the sheet-like fibrous structures 4a to 4e have a web 2 stacked so that the web extends in a thickness direction of the fibrous structures. The surface layer sheet-like fibrous structure 4e has a thickness substantially equal to or smaller than a depth of the groove portion 12.

Abstract: A cushion body which has a force to support a large load and both a soft touch feeling and can maintain an undulation shape of a groove portion and the like provided on a contact surface with a seat occupant favorable, a seat using the same, and a manufacturing method thereof are provided.