Patents by Inventor Mika Jokinen
Mika Jokinen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240024231Abstract: The present invention relates to a hydrogel material hydrogel material, comprising a first hydrogel comprising 0.15-21 wt-% of a functionalised triblock molecule having a formula (1) wherein n is 4-680 and m is 1-10, based on a total weight of the first hydrogel. The first hydrogel further comprises 0.85-3.3 wt-% of silica, based on the total weight of the first hydrogel, and 75-99 wt-% of an aqueous liquid, based on the total weight of the first hydrogel. The —Si—OH groups of the silica form a —Si—O—Si— bond with the —Si—(O)3— group of the functionalised triblock molecule of formula (1).Type: ApplicationFiled: September 29, 2021Publication date: January 25, 2024Inventors: Mika Jokinen, Alar Kaljukivi, Ari Rosling, Tatu Assmuth, Vesna Blazevic, Vesa Hytönen, Olli Laitinen, Suvi Heinimäki
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Publication number: 20230248647Abstract: The present invention relates to a silica hydrogel composite comprising non-active silica particles and solid particles of active pharmaceutical ingredient or ingredients. The silica hydrogel composite is feasible for controlled and sustained delivery of active pharmaceutical ingredients.Type: ApplicationFiled: July 7, 2021Publication date: August 10, 2023Inventors: Minna Vaahtio, Mika Kaimainen, Ari-Pekka Forsback, Mika Jokinen, Lasse Leino
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Patent number: 10172792Abstract: This invention relates to a depot formulation comprising a biodegradable silica hydrogel composite incorporating a nucleotide or nucleoside analog reverse transcriptase inhibitor, wherein the silica hydrogel composite is obtainable by mixing silica particles comprising said nucleotide or nucleoside analog reverse transcriptase inhibitor and having a maximum diameter of ?1 000 ?m, as such or as a suspension, with silica sol wherein the hydrogel composite is non-flowing and structurally stable when stored at rest and shear-thinning when shear stress is applied by injection. The present invention also relates to use of the depot formulation for treatment of chronic viral infections and prevention of chronic viral reinfection. The present invention further relates to a prefilled syringes comprising said depot formulation.Type: GrantFiled: October 21, 2016Date of Patent: January 8, 2019Assignee: DelSiTech OyInventors: Lasse Leino, Harry Jalonen, Ari-Pekka Forsback, Mika Jokinen, Panu Noppari
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Patent number: 10149825Abstract: A method for preparing a sol-gel derived SiO2 having a very fast bioresorption rate where a sol-gel derived SiO2 is prepared from a sol comprising water, an alkoxide or inorganic silicate and a lower alcohol using a mineral acid or a base as a catalyst and the sol is aged and dried. The method uses a pH from 1.5 to 2.5, a molar ratio of water to the alkoxide or inorganic silicate of 0.5 to 2.5, a molar ratio of alcohol to the alkoxide or inorganic silicate is ?0.5; and the sol is either let to gel without induced changes of composition and without forced drying of the sol, or a change of composition is induced; and within a time of ?30 minutes, from the induced change forced drying of the sol is carried out or initiated.Type: GrantFiled: February 22, 2005Date of Patent: December 11, 2018Assignee: DelSiTech OyInventors: Mika Jokinen, Reeta Viitala, Harry Jalonen
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Publication number: 20180311150Abstract: This invention relates to a depot formulation comprising a biodegradable silica hydrogel composite incorporating a nucleotide or nucleoside analogue reverse transcriptase inhibitor, wherein the silica hydrogel composite is obtainable by mixing silica particles comprising said nucleotide or nucleoside analogue reverse transcriptase inhibitor and having a maximum diameter of ?1 000 ?m, as such or as a suspension, with silica sol wherein the hydrogel composite is non-flowing and structurally stable when stored at rest and shear-thinning when shear stress is applied by injection. The present invention also relates to use of the depot formulation for treatment of chronic viral infections and prevention of chronic viral reinfection. The present invention further relates to a prefilled syringes comprising said depot formulation.Type: ApplicationFiled: October 21, 2016Publication date: November 1, 2018Applicant: DelSiTech OyInventors: Lasse LEINO, Harry JALONEN, Ari-Pekka FORSBACK, Mika JOKINEN, Panu NOPPARI
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Patent number: 9949922Abstract: This invention relates to a silica hydrogel composite obtainable by mixing silica particles, comprising an encapsulated agent, with a silica sol, wherein obtained hydrogel composite is shear-thinning. The present invention also relates to use of the silica hydrogel composite according to the invention for an injectable, flowing or extrudable formulation. The present invention further relates to a method for preparing the silica hydrogel.Type: GrantFiled: June 18, 2014Date of Patent: April 24, 2018Assignee: DelSiTech OyInventors: Mika Jokinen, Harry Jalonen, Ari-Pekka Forsback
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Publication number: 20160136088Abstract: This invention relates to a silica hydrogel composite obtainable by mixing silica particles, comprising an encapsulated agent, with a silica sol, wherein obtained hydrogel composite is shear-thinning. The present invention also relates to use of the silica hydrogel composite according to the invention for an injectable, flowing or extrudable formulation. The present invention further relates to a method for preparing the silica hydrogel.Type: ApplicationFiled: June 18, 2014Publication date: May 19, 2016Applicant: DelSiTech OyInventors: Mika JOKINEN, Harry JALONEN, Ari-Pekka FORSBACK
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Patent number: 9226893Abstract: A method for storing a water-soluble undissolved silica-based material, optionally with an incorporated functional agent. The method includes immersing the material in an aqueous liquid phase which is initially saturated with a water-soluble silica-based material which is the same or different than the undissolved silica-based material, such that the undissolved silica-based material does not essentially dissolve into the liquid phase during storage, or the proportion of the amount of the initially undissolved silica-based material to the amount of the liquid phase is such that the liquid phase will be saturated or essentially saturated by a dissolved portion of the water-soluble undissolved silica-based material during storage, which dissolved portion of said water soluble undissolved silica-based material is less than 20%. Also disclosed is a storage package which may preferably be used to store functional agents, delivery devices or implants.Type: GrantFiled: May 23, 2007Date of Patent: January 5, 2016Assignee: DelSiTech OyInventors: Mika Jokinen, Mika Koskinen, Harry Jalonen
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Publication number: 20140057996Abstract: A method for producing a flowing silica composition including a sol-gel transfer, where redispersion is carried out. The redispersion includes adding, after having reached gel point of the sol-gel transfer, liquid into the gel formed by the sol-gel transfer, and the addition being made within a sufficiently short time period after reaching the gel point, to result, after mixing of the gel and the liquid, in a rheologically homogenous flowing silica composition, which is and remains injectable as such, or by short stirring <30 s, through a thin 22G needle. Also disclosed are flowing silica compositions and gels obtainable by methods of the invention, and uses of flowing silica compositions.Type: ApplicationFiled: August 20, 2013Publication date: February 27, 2014Applicant: DelSiTech OyInventors: Mika JOKINEN, Harry JALONEN, Ari-Pekka FORSBACK, Mika KOSKINEN
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Patent number: 7897166Abstract: A method for preparing controllably biodegradable silica fibres which includes spinning the fibres from a silica sol of controlled viscosity, controllably biodegradable silica fibres prepared according to the method, methods for controlling the biodegradability of the fibres, the use of controllably biodegradable fibres as sustained and/or controlled release delivery devices for biologically active agents, and pharmaceutical preparations containing such devices.Type: GrantFiled: February 21, 2000Date of Patent: March 1, 2011Assignee: DelSiTech OyInventors: Mika Jokinen, Timo Peltola, Sinikka Veittola, Manja Ahola, Pirjo Kortesuo
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Publication number: 20100136657Abstract: A method for storing a water-soluble undissolved silica-based material, optionally with an incorporated functional agent. The method includes immersing the material in an aqueous liquid phase which is initially saturated with a water-soluble silica-based material which is the same or different than the undissolved silica-based material, such that the undissolved silica-based material does not essentially dissolve into the liquid phase during storage, or the proportion of the amount of the initially undissolved silica-based material to the amount of the liquid phase is such that the liquid phase will be saturated or essentially saturated by a dissolved portion of the water-soluble undissolved silica-based material during storage, which dissolved portion of said water soluble undissolved silica-based material is less than 20%. Also disclosed is a storage package which may preferably be used to store functional agents, delivery devices or implants.Type: ApplicationFiled: May 23, 2007Publication date: June 3, 2010Inventors: Mika Jokinen, Mika Koskinen, Harry Jalonen
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Publication number: 20100119500Abstract: A method for producing a flowing silica composition including a sol-gel transfer, where redispersion is carried out. The redispersion includes adding, after having reached gel point of the sol-gel transfer, liquid into the gel formed by the sol-gel transfer, and the addition being made within a sufficiently short time period after reaching the gel point, to result, after mixing of the gel and the liquid, in a rheologically homogenous flowing silica composition, which is and remains injectable as such, or by short stirring <30 s, through a thin 22 G needle. Also disclosed are flowing silica compositions and gels obtainable by methods of the invention, and uses of flowing silica compositions.Type: ApplicationFiled: February 22, 2008Publication date: May 13, 2010Inventors: Mika Jokinen, Harry Jalonen, Ari-Pekka Forsback, Mika Koskinen
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Patent number: 7527804Abstract: A method for improving soft tissue attachment which includes the steps of coating a surface of a material, to which surface soft tissue is to be attached, with a coating rich in TiO2 and/or SiO2, and applying the coating where soft tissue attachment is desired. An implant in which a surface or surfaces of the implant intended to be attached to soft tissue are coated with a porous coating rich in TiO2 and/or SiO2, and the use of a porous surface coating rich in TiO2, SiO2, or TiO2 and SiO2, for the manufacture of an implant for soft tissue attachment are also disclosed.Type: GrantFiled: April 25, 2002Date of Patent: May 5, 2009Assignee: Vivoxid OyInventors: Timo Närhi, Hannu Paldan, Antti Yli-Urpo, Timo Peltola, Mika Jokinen, Risto-Pekka Happonen
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Publication number: 20070196427Abstract: The present invention relates to a method for preparing a sol-gel derived SiO2 with a very fast bioresorption rate wherein a sol-gel derived SiO2 is prepared from a sol comprising water, an alkoxide or inorganic silicate and a lower alcohol using a mineral acid or a base as a catalyst and said sol is aged and dried. Characteristic for the method is that pH is from 1.5 to 2.5, molar ratio of water to the alkoxide or inorganic silicate is 0.5 to 2.5, of alcohol to the alkoxide or inorganic silicate is ?0.5; and the sol is either let to gel without induced changes of composition and without forced drying of the sol, or a change of composition are induced; and within a time of ?30 minutes, from the induced change forced drying of the sol is carried out or initiated. The present invention also relates to a method for adjusting the bioresorption rate of sol-gel derived SiO2.Type: ApplicationFiled: February 22, 2005Publication date: August 23, 2007Inventors: Mika Jokinen, Reeta Viitala, Harry Jalonen
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Publication number: 20040132603Abstract: The invention relates to a method for improving soft tissue attachment comprising the steps of coating a surface of a material, to which surface soft tissue is to be attached, with a coating rich in TiO2 and/or SiO2, and applying said coating wherein soft tissue attachment is desired. The invention further relates to an implant wherein a surface or surfaces of said implant intended to be attached to soft tissue are coated with a porous coating rich in TiO2 and/or SiO2. The invention also relates to the use of a porous surface coating rich in TiO2, SiO2, or TiO2 and SiO2, for the manufacture of an implant for soft tissue attachment to said coating.Type: ApplicationFiled: October 27, 2003Publication date: July 8, 2004Inventors: Timo Narhi, Hannu Paldan, Antti Yli-Urpo, Timo Peltola, Mika Jokinen, Risto-Pekka Happonen
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Publication number: 20040121451Abstract: A method for at least partially treating biologically active sols, gels, mixtures or composites of sols and gels, and/or sol-gel derived materials, the sols, gels, mixtures or composites of sols and gels, and/or sol-gel derived materials having OH-groups and being at least partially amorphous, the treatment being performed with a localised electromagnetic and/or acoustic energy. A method for coating a device with biologically active sols, gels, mixtures or composites of sols and gels, and/or sol-gel derived materials and a method for modifying the biological activity of biologically active sols, gels, mixtures or composites of sols and gels, and/or sol-gel derived materials are also disclosed. Both methods include treatment with localised electromagnetic and/or acoustic energy. Also disclosed is the use of the method to fabricate different devices and to attach at least two devices.Type: ApplicationFiled: February 19, 2004Publication date: June 24, 2004Inventors: Niko Moritz, Ilkka Kangasniemi, Antti Yli-Urpo, Timo Peltola, Mika Jokinen
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Publication number: 20040033187Abstract: This invention relates to bioactive sol-gel derived silica fibers, methods for their preparation, an implantable device comprising said fibers and the use of said device for tissue guiding or bone repair.Type: ApplicationFiled: April 11, 2003Publication date: February 19, 2004Inventors: Timo Peltola, Mika Jokinen, Sinikka Veittola, Antti Yli-Urpo
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Patent number: 6632412Abstract: This invention relates to bioactive sol-gel derived silica fibers, methods for their preparation, an implantable device comprising the fibers and the use of the device for tissue guiding or bone repair.Type: GrantFiled: December 1, 1999Date of Patent: October 14, 2003Inventors: Timo Peltola, Mika Jokinen, Sinikka Veittola, Antti Yli-Urpo
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Publication number: 20030167967Abstract: The invention relates to glass ionomer for enhancing mineralization of hard tissue of mammals. The glass ionomer comprises, a inert biocompatible ceramic and a bioactive ceramic. The invention also relates to a method for enhancing mineralization of hard tissue of mammals with the aid of said glass ionomer. The invention further relates to the use of said glass ionomer for the preparation of products intended for treatment of defects of soft and hard tissue as well as the use of said glass ionomer for the preparation of a variety of products wherein the ability to enhance mineralization is advantageous.Type: ApplicationFiled: March 1, 2002Publication date: September 11, 2003Inventors: Timo Narhi, Antti Yli-Urpo, Helena Yli-Urpo, Joni Korventausta, Mika Jokinen
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Publication number: 20020064493Abstract: This invention relates to bioactive sol-gel derived silica fibers, methods for their preparation, an implantable device comprising said fibers and the use of said device for tissue guiding or bone repair.Type: ApplicationFiled: December 1, 1999Publication date: May 30, 2002Inventors: TIMO PELTOLA, Mika Jokinen, Sinikka Veittola, Antti Yli-urpo