Patents by Inventor Mika Makino

Mika Makino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Endothelin-antagonizing peptide
    Patent number: 6642355
    Abstract: The invention relates to an endothelin antagonistic peptide of the formula (I): X-A-Trp-B-Gly-Thr-E-G-Y   (I) SEQ ID NO: 2 wherein represents Asn or Asp; B represents His or Lys; E represents Ala or Ser; G represents Ala or Pro; X represents X1-Gly or  and Y represents hydroxy, lower alkoxy, amino, wherein X1, X3, Y1, Y2 and Z are further defined, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: January 2, 2001
    Date of Patent: November 4, 2003
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Takeo Tanaka, Yoshikazu Morishita, Mika Makino, Shigeru Chiba, Isao Kawamoto, Eiji Tsukuda, Mayumi Yoshida, Chieko Bando, Kazuo Yamaguchi, Yuzuru Matsuda, Shigeto Kitamura, Toshihide Ikemura, Tatsuhiro Ogawa, Keiichi Yano, Toshiyuki Suzawa, Kenji Shibata, Motoo Yamasaki
  • Endothelin-antagonizing peptide
    Publication number: 20030055213
    Abstract: Disclosed in a peptide represented by the following formula (I):
    Type: Application
    Filed: January 2, 2001
    Publication date: March 20, 2003
    Inventors: Takeo Tanaka, Yoshikazu Morishita, Mika Makino, Shigeru Chiba, Isao Kawamoto, Eiji Tsukuda, Mayumi Yoshida, Chieko Bando, Kazuo Yamaguchi, Yuzuru Matsuda, Shigeto Kitamura, Toshihide Ikemura, Tatsuhiro Ogawa, Keiichi Yano, Toshiyuki Suzawa, Kenji Shibata, Motoo Yamasaki
  • Strains of streptomyces producing endothelin antagonistic peptides
    Patent number: 6194195
    Abstract: The invention relates to biologically pure cultures of Streptomyces sp. RE-701 (FERM BP-3624) and Streptomyces sp. RE-629 (FERM BP-4126) that produce endothelin antagonistic peptides.
    Type: Grant
    Filed: October 27, 1998
    Date of Patent: February 27, 2001
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Takeo Tanaka, Yoshikazu Morishita, Mika Makino, Shigeru Chiba, Isao Kawamoto, Eiji Tsukuda, Mayumi Yoshida, Chieko Bando, Kazuo Yamaguchi, Yuzuru Matsuda, Shigeto Kitamura, Toshihide Ikemura, Tatsuhiro Ogawa, Keiichi Yano, Toshiyuki Suzawa, Kenji Shibata, Motoo Yamasaki
  • Endothelin-antagonizing peptide
    Patent number: 5639860
    Abstract: Peptides represented by the following formula (I): ##STR1## wherein A represents Asn or Asp; B represents His or Lys; and E represents Ala or Ser;(1) X.sup.1 and Y.sup.1 are combined together to form a single bond as X.sup.1 --Y1, or (2) X.sup.1 represents hydrogen and Y.sup.1 represents hydroxy;and Z represents, in case of (1),Trp-Phe-Phe-Asn-Tyr-Tyr-7Hyt-Z.sup.1Trp-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-Z.sup.1,Trp-Val-Tyr-Tyr-Ala-His-Leu-Asp-Ile-Ile-Trp-Z.sup.1,Trp-Leu-Tyr-Phe-Ala-His-Gln-Asp-Val-Ile-Trp-Z.sup.1,Trp-Phe-Phe-Asn-Tyr-R-T-Z.sup.1wherein Z.sup.1 is an organic moiety,wherein R is Tyr or a covalent bond,T is Trp, Ala, Phe, Tyr, Trp-Trp, Asn-Tyr-Tyr-Trp, Trp-Asn-Tyr-Tyr-Trp, Trp-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp,or in case of (2), Z representsTrp-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-Z.sup.1Trp-Val-Tyr-Tyr-Ala-His-Leu-Asp-Ile-Ile-Trp-Z.sup.1Trp-Leu-Tyr-Phe-Ala-His-Gln-Asp-Val-Ile-Trp-Z.sup.1.
    Type: Grant
    Filed: October 12, 1994
    Date of Patent: June 17, 1997
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Takeo Tanaka, Yoshikazu Morishita, Mika Makino, Shigeru Chiba, Isao Kawamoto, Eiji Tsukuda, Mayumi Yoshida, Chieko Bando, Kazuo Yamaguchi, Yuzuru Matsuda, Shigeto Kitamura, Toshihide Ikemura, Tatsuhiro Ogawa, Keiichi Yano, Toshiyuki Suzawa, Kenji Shibata, Motoo Yamasaki