Patents by Inventor Mika Moriya
Mika Moriya has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20230416793Abstract: Provided is a method of producing an L-amino acid such as L-glutamic acid and the like. An L-amino-acid is produced by cultivating a coryneform bacterium having L-amino acid-producing ability in a culture medium, which has been modified so as to have one or more of the following modifications: (A) a modification for increasing activity of acetate kinase, (B) a modification for increasing activity of fructose-1,6-bisphosphatase, (C) a modification for decreasing activity of pyruvate dehydrogenase, (D) a modification for decreasing activity of aspartate transaminase, and (E) a modification for decreasing activity of malic enzyme; and collecting the L-amino acid from the culture medium and/or the bacterial cells.Type: ApplicationFiled: April 27, 2023Publication date: December 28, 2023Applicant: Ajinomoto Co., Inc.Inventors: Seiko Hirano, Kota Inoue, Kazuyuki Hayashi, Kosuke Yokota, Mika Moriya, Tomoko Suzuki, Yoshitomo Kadokura, Takeshi Nagahiko, Akari Tashiro
-
Patent number: 10941420Abstract: The present invention provides a composition containing linalool, wherein the composition contains a high amount of either enantiomer R-linalool or S-linalool, and has a high content rate of linalool. The present invention also provides a production method for producing the composition. The present invention further provides a composition containing volatile components including linalool, in which a content of linalool in a total content of the volatile components in the composition is 60% or more, and the linalool is present as R-linalool or S-linalool in an amount of 50% or more of the enantiomer, and a production method therefor.Type: GrantFiled: March 21, 2018Date of Patent: March 9, 2021Assignee: AJINOMOTO CO., INC.Inventors: Yasushi Hoshino, Yoshiko Inoue, Mika Moriya, Akiko Matsudaira, Yosuke Nishio
-
Patent number: 10870866Abstract: The present invention describes an efficient method for producing linalool. The present invention provides a method for producing linalool, the method including culturing a microorganism expressing linalool synthase in a culture medium to produce linalool. The present invention also describes a microorganism able to express linalool synthase and efficiently produce linalool.Type: GrantFiled: March 21, 2018Date of Patent: December 22, 2020Assignee: AJINOMOTO CO., INC.Inventors: Yasushi Hoshino, Akiko Matsudaira, Mika Moriya, Nobuhisa Nitta, Yosuke Nishio
-
Patent number: 10428359Abstract: A method for producing an L-amino acid such as L-glutamic acid is provided. An L-amino acid is produced by culturing a bacterium having an L-amino acid-producing ability, which has been modified so that the activity of a C4-dicarboxylic acid-uptake carrier such as DctA, DcuA, and DcuB is increased, in a medium, and collecting the L-amino acid from the medium or cells of the bacterium.Type: GrantFiled: September 27, 2017Date of Patent: October 1, 2019Assignee: AJINOMOTO CO, INC.Inventors: Mika Moriya, Kazuyuki Hayashi, Akari Yokokawa
-
Publication number: 20180291402Abstract: The present invention provides a composition containing linalool, wherein the composition contains a high amount of either enantiomer R-linalool or S-linalool, and has a high content rate of linalool. The present invention also provides a production method for producing the composition. The present invention further provides a composition containing volatile components including linalool, in which a content of linalool in a total content of the volatile components in the composition is 60% or more, and the linalool is present as R-linalool or S-linalool in an amount of 50% or more of the enantiomer, and a production method therefor.Type: ApplicationFiled: March 21, 2018Publication date: October 11, 2018Applicant: AJINOMOTO CO., INC.Inventors: Yasushi Hoshino, Yoshiko Inoue, Mika Moriya, Akiko Matsudaira, Yosuke Nishio
-
Publication number: 20180291403Abstract: The present invention describes an efficient method for producing linalool. The present invention provides a method for producing linalool, the method including culturing a microorganism expressing linalool synthase in a culture medium to produce linalool. The present invention also describes a microorganism able to express linalool synthase and efficiently produce linalool.Type: ApplicationFiled: March 21, 2018Publication date: October 11, 2018Applicant: AJINOMOTO CO., INC.Inventors: Yasushi Hoshino, Akiko Matsudaira, Mika Moriya, Nobuhisa Nitta, Yosuke Nishio
-
Publication number: 20180094285Abstract: A method for producing an L-amino acid such as L-glutamic acid is provided. An L-amino acid is produced by culturing a bacterium having an L-amino acid-producing ability, which has been modified so that the activity of a C4-dicarboxylic acid-uptake carrier such as DctA, DcuA, and DcuB is increased, in a medium, and collecting the L-amino acid from the medium or cells of the bacterium.Type: ApplicationFiled: September 27, 2017Publication date: April 5, 2018Applicant: AJINOMOTO CO., INC.Inventors: Mika Moriya, Kazuyuki Hayashi, Akari Yokokawa
-
Patent number: 9487806Abstract: A method for producing of an L-amino acid is provided. An L-amino acid is produced by culturing a bacterium belonging to the family Enterobacteriaceae and having an L-amino acid-producing ability, which has been modified so that the acpP-fabF operon is attenuated, in a medium, and collecting the L-amino acid from the medium or cells of the bacterium.Type: GrantFiled: June 10, 2015Date of Patent: November 8, 2016Assignee: Ajinomoto Co., Inc.Inventors: Miku Toyazaki, Keiko Noguchi, Mika Moriya, Yuri Uehara
-
Publication number: 20150275246Abstract: A method for producing of an L-amino acid is provided. An L-amino acid is produced by culturing a bacterium belonging to the family Enterobacteriaceae and having an L-amino acid-producing ability, which has been modified so that the acpP-fabF operon is attenuated, in a medium, and collecting the L-amino acid from the medium or cells of the bacterium.Type: ApplicationFiled: June 10, 2015Publication date: October 1, 2015Applicant: AJINOMOTO CO., INC.Inventors: Miku Toyazaki, Keiko Noguchi, Mika Moriya, Yuri Uehara
-
Patent number: 8722370Abstract: The present invention provides a method for producing L-amino acids, such as L-arginine, L-citrulline, and L-lysine, using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus Escherichia or Pantoea, which has been modified to attenuate expression of one or more genes, such as the pepA, pepB, and pepD genes.Type: GrantFiled: November 28, 2012Date of Patent: May 13, 2014Assignee: Ajinomoto Co., Inc.Inventors: Dmitriy Vladimirovich Filippov, Tatyana Viktorovna Leonova, Elvira Borisovna Voroshilova, Mikhail Markovich Gusyatiner, Mika Moriya, Yuri Nagai, Keiko Noguchi
-
Publication number: 20120295314Abstract: The present invention provides a method of producing 2R,4R-Monatin with a good yield using inexpensive L-Trp rather than expensive D-Trp as a stating material. Specifically, the present invention provides a method for producing 2R,4R-Monatin or a salt thereof, comprising: (1) contacting L-tryptophan with a deamination enzyme to form indole-3-pyruvate; (2) contacting the indole-3-pyruvate and pyruvate with an aldolase to form 4R-IHOG; and (3) contacting the 4R-IHOG with a D-aminotransferase in the presence of a D-amino acid to form the 2R,4R-Monatin; and the like. In (3), it is preferable to use a D-aminotransferase having no or low ability to form D-tryptophan from indole-3-pyruvate.Type: ApplicationFiled: April 25, 2012Publication date: November 22, 2012Applicant: Ajinomoto Co., Inc.Inventors: Masakazu Sugiyama, Yasuaki Takakura, Mika Moriya, Yusuke Hagiwara, Eri Tabuchi
-
Patent number: 8129151Abstract: L-Glutamic acid is produced by culturing in a liquid culture medium a microorganism belonging to the genus Pantoea or Serratia and having an ability to produce L-glutamic acid, which increases in an activity of enzyme catalyzing a reaction for L-glutamic acid biosynthesis or which decreases in or is deficient in an activity of an enzyme catalyzing a reaction branching from a pathway for L-glutamic acid biosynthesis and producing a compound other than L-glutamic acid, and collecting produced L-glutamic acid from the culture medium.Type: GrantFiled: January 17, 2007Date of Patent: March 6, 2012Assignee: Ajinomoto Co., Inc.Inventors: Mika Moriya, Hiroshi Izui, Eiji Ono, Kazuhiko Matsui, Hisao Ito, Yoshihiko Hara
-
Patent number: 8030036Abstract: A bacterium belonging to the genus Escherichia which has an ability to produce L-lysine or L-threonine and which is modified so that a malic enzyme does not function normally in a cell, and a method for producing L-lysine or L-threonine, comprising culturing the bacterium in a medium to produce and cause accumulation of L-lysine or L-threonine, and collecting the L-lysine or L-threonine from the medium.Type: GrantFiled: October 24, 2007Date of Patent: October 4, 2011Assignee: Ajinomoto Co., Inc.Inventors: Stephen Van Dien, Shintaro Iwatani, Yoshihiro Usuda, Kazuhiko Matsui, Yuta Nakai, Tomoko Suzuki, Mika Moriya, Yuichiro Tsuji, Takuji Ueda
-
Patent number: 7763447Abstract: Succinic acid is produced by allowing a bacterium modified to enhance fumarate reductase activity or cell preparation thereof to react with an organic raw material in a reaction solution containing one of a carbonate ion, a bicarbonate ion, and carbon dioxide gas to generate succinic acid. More preferably, succinic acid is produced by allowing a bacterium modified to enhance activities of fumarate reductase and pyruvate carboxylase and decrease lactate dehydrogenase activity or cell preparation thereof to react with an organic raw material in a reaction solution containing one of a carbonate ion, a bicarbonate ion, and carbon dioxide gas to generate succinic acid. Succinic acid is obtained by collecting the produced succinic acid.Type: GrantFiled: February 28, 2006Date of Patent: July 27, 2010Assignee: Ajinomoto Co., Inc.Inventors: Makoto Murase, Ryusuke Aoyama, Miki Ikuta, Kenji Yamagishi, Mika Moriya, Jun Nakamura, Hiroyuki Kojima
-
Publication number: 20090263874Abstract: L-Glutamic acid is produced by culturing in a liquid culture medium a microorganism belonging to the genus Enterobacter or Serratia and having an ability to produce L-glutamic acid, which increases in an activity of enzyme catalyzing a reaction for L-glutamic acid biosynthesis or which decreases in or is deficient in an activity of an enzyme catalyzing a reaction branching from a pathway for L-glutamic acid biosynthesis and producing a compound other than L-glutamic acid, and collecting produced L-glutamic acid from the culture medium.Type: ApplicationFiled: January 17, 2007Publication date: October 22, 2009Applicant: AJINOMOTO CO. INCInventors: Mika Moriya, Hiroshi Izui, Eiji Ono, Kazuhiko Matsui, Hisao Ito, Yoshihiko Hara
-
Publication number: 20090162907Abstract: A microorganism which can metabolize a carbon source at a specific pH in a liquid medium containing L-glutamic acid at a saturation concentration and the carbon source, and has ability to accumulate L-glutamic acid in an amount exceeding the amount corresponding to the saturation concentration in the liquid medium at the pH; and a method for producing L-glutamic acid by fermentation, which comprises culturing the microorganism in a liquid medium of which pH is adjusted to a pH at which L-glutamic acid is precipitated, to produce and accumulate L-glutamic acid and precipitate L-glutamic acid in the medium.Type: ApplicationFiled: November 7, 2008Publication date: June 25, 2009Applicant: Ajinomoto Co., Inc.Inventors: Hiroshi IZUI, Mika Moriya, Seiko Hirano, Yoshihiko Hara, Hisao Ito, Kazuhiko Matsui
-
Publication number: 20090148915Abstract: A bacterium belonging to the genus Escherichia which has an ability to produce L-lysine or L-threonine and which is modified so that a malic enzyme does not function normally in a cell, and a method for producing L-lysine or L-threonine, comprising culturing the bacterium in a medium to produce and cause accumulation of L-lysine or L-threonine, and collecting the L-lysine or L-threonine from the medium.Type: ApplicationFiled: October 24, 2007Publication date: June 11, 2009Inventors: Stephen Van Dien, Shintaro Iwatani, Yoshihiro Usuda, Kazuhiko Matsui, Yuta Nakai, Tomoko Suzuki, Mika Moriya, Yuichiro Tsuji, Takuji Ueda
-
Patent number: 7306933Abstract: A bacterium belonging to the genus Escherichia which has an ability to produce L-lysine or L-threonine and which is modified so that a malic enzyme does not function normally in a cell, and a method for producing L-lysine or L-threonine, comprising culturing the bacterium in a medium to produce and cause accumulation of L-lysine or L-threonine, and collecting the L-lysine or L-threonine from the medium.Type: GrantFiled: January 3, 2006Date of Patent: December 11, 2007Assignee: Ajinomoto Co., Inc.Inventors: Stephen Van Dien, Shintaro Iwatani, Yoshihiro Usuda, Kazuhiko Matsui, Yuta Nakai, Tomoko Suzuki, Mika Moriya, Yuichiro Tsuji, Takuji Ueda
-
Patent number: 7247459Abstract: L-glutamic acid is produced by culturing in a medium a microorganism belonging to enterobacteria and having L-glutamic acid productivity, into which a citrate synthase gene derived from a coryneform bacterium is introduced to produce and accumulate L-glutamic acid in the medium and collecting the L-glutamic acid from the medium.Type: GrantFiled: October 18, 1999Date of Patent: July 24, 2007Assignee: Ajinomoto Co., Inc.Inventors: Hiroshi Izui, Mika Moriya, Yoshihiko Hara, Hisao Ito
-
Patent number: RE42350Abstract: A microorganism is provided which can metabolize a carbon source at a specific pH in a liquid medium containing L-glutamic acid at a saturation concentration and the carbon source, and which has ability to accumulate L-glutamic acid in an amount exceeding the amount corresponding to the saturation concentration in the liquid medium at the pH. Also provided is a method for producing L-glutamic acid by fermentation, which comprises culturing the microorganism in a liquid medium of which pH is adjusted to a pH at which L-glutamic acid is precipitated, to produce and accumulate L-glutamic acid and precipitate L-glutamic acid in the medium.Type: GrantFiled: April 24, 2009Date of Patent: May 10, 2011Assignee: Ajinomoto Co., Inc.Inventors: Hiroshi Izui, Mika Moriya, Seiko Hirano, Yoshihiko Hara, Hisao Ito, Kazuhiko Matsui