Patents by Inventor Mikael Elias

Mikael Elias has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mutated PTE enzymes
    Patent number: 11466261
    Abstract: Disclosed are mutated phosphotriesterase enzymes with improved stability and activity, as well as their use in particular for degrading organophosphorus compounds.
    Type: Grant
    Filed: July 17, 2018
    Date of Patent: October 11, 2022
    Assignees: LA FONDATION MEDITERRANEE INFECTION, I.N.S.E.R.M. (INSTITUT NATIONAL DE LA SANTÉET DE LA RECHERCHE MÉDICALE), GENE AND GREEN TK, ASSISTANCE PUBLIQUE-HOPITAUX DE MARSEILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, AIX-MARSEILLE UNIVERSITE, REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Eric Chabriere, David Daude, Mikael Elias
  • PROTEINS AND METHODS FOR DISRUPTING BACTERIAL COMMUNICATION
    Publication number: 20220154156
    Abstract: Provided herein are lactonases. In one embodiment, the lactonases are metallo-?-lactamase-like lactonase (MLL) enzymes having altered characteristics such as altered catalytic activity and/or altered substrate specificity. Also provided are genetically modified microbes able to express a MLL enzyme, compositions that include a MLL enzyme, and methods of using a MLL enzyme.
    Type: Application
    Filed: March 11, 2020
    Publication date: May 19, 2022
    Inventors: Celine Bergonzi, Mikael Elias, Randall Hicks, Michael Sadowsky, Michael Schwab
  • NOVEL MUTATED PTE ENZYMES
    Publication number: 20200231950
    Abstract: Disclosed are mutated phosphotriesterase enzymes with improved stability and activity, as well as their use in particular for degrading organophosphorus compounds.
    Type: Application
    Filed: July 17, 2018
    Publication date: July 23, 2020
    Inventors: Eric CHABRIERE, David DAUDE, Mikael ELIAS
  • Vulcanisaetal phosphotriesterase-like lactonases (PLL) having enhanced properties and the uses thereof
    Patent number: 10202587
    Abstract: Provided is a mutated hyperthermophilic PTE having a lactonase activity derived from a hyperthermophilic phosphotriesterase corresponding to the consensus sequence of SEQ ID NO: 1, the mutated PTE including the at least one mutation chosen amongst 55 putative positions and the mutated PTE having enhanced properties. Also provided are compositions including the mutated hyperthermophilic PTE and the uses thereof, notably as bioscavenger of organophosphate compounds or as quorum quencher of the bacteria using lactones to communicate.
    Type: Grant
    Filed: July 31, 2014
    Date of Patent: February 12, 2019
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE D'AIX-MARSEILLE
    Inventors: Eric Chabriere, Mikael Elias, Julien Hiblot, Didier Raoult
  • SULFOLOBAL PHOSPHOTRIESTERASE-LIKE (PLL) LACTONASES ACTIVITY HAVING ENHANCED PROPERTIES AND THE USES THEREOF
    Publication number: 20190040369
    Abstract: Mutated hyperthermophilic PTE having a lactonase activity derived from a hyperthermophilic phosphotriesterase corresponding to the consensus sequence of SEQ ID NO: 1, the mutated PTE including the at least one mutation chosen amongst 53 putative positions and the mutated PTE having enhanced properties. Also provided are compositions including the mutated hyperthermophilic PTE and the uses thereof, notably as bioscavenger of organophosphate compounds or as quorum quencher of the bacteria using lactones to communicate.
    Type: Application
    Filed: August 7, 2018
    Publication date: February 7, 2019
    Inventors: Eric Chabriere, Mikael Elias, Julien Hiblot, Didier Raoult
  • Sulfolobal phosphotriesterase-like (PLL) lactonases activity having enhanced properties and the uses thereof
    Patent number: 10072252
    Abstract: Mutated hyperthermophilic PTE having a lactonase activity derived from a hyperthermophilic phosphotriesterase corresponding to the consensus sequence of SEQ ID NO: 1, the mutated PTE including the at least one mutation chosen amongst 53 putative positions and the mutated PTE having enhanced properties. Also provided are compositions including the mutated hyperthermophilic PTE and the uses thereof, notably as bioscavenger of organophosphate compounds or as quorum quencher of the bacteria using lactones to communicate.
    Type: Grant
    Filed: April 14, 2014
    Date of Patent: September 11, 2018
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE D'AIX-MARSEILLE
    Inventors: Eric Chabriere, Mikael Elias, Julien Hiblot, Didier Raoult
  • Antiviral agent
    Patent number: 9492501
    Abstract: The present invention describes the use of a composition including or constituted by at least one element chosen from: a specific protein including or consisting of the amino acid sequence SEQ ID NO: 5, and a protein homologous to the specific protein, for the preparation of a medicament intended for the prevention or treatment of pathologies associated with a viral infection or an inflammation.
    Type: Grant
    Filed: March 4, 2010
    Date of Patent: November 15, 2016
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE STRASBOURG, UNIVERSITE DE LA MEDITERRANEE
    Inventors: Eric Chabriere, Mikael Elias, Olivier Rohr, Christian Schwartz
  • VULCANISAETAL PHOSPHOTRIESTERASE-LIKE LACTONASES (PLL) HAVING ENHANCED PROPERTIES AND THE USES THEREOF
    Publication number: 20160237413
    Abstract: Provided is a mutated hyperthermophilic PTE having a lactonase activity derived from a hyperthermophilic phosphotriesterase corresponding to the consensus sequence of SEQ ID NO: 1, the mutated PTE including the at least one mutation chosen amongst 55 putative positions and the mutated PTE having enhanced properties. Also provided are compositions including the mutated hyperthermophilic PTE and the uses thereof, notably as bioscavenger of organophosphate compounds or as quorum quencher of the bacteria using lactones to communicate.
    Type: Application
    Filed: July 31, 2014
    Publication date: August 18, 2016
    Inventors: Eric CHABRIERE, Mikael ELIAS, Julien HIBLOT, Didier RAOULT
  • SULFOLOBAL PHOSPHOTRIESTERASE-LIKE (PLL) LACTONASES ACTIVITY HAVING ENHANCED PROPERTIES AND THE USES THEREOF
    Publication number: 20160115462
    Abstract: Mutated hyperthermophilic PTE having a lactonase activity derived from a hyperthermophilic phosphotriesterase corresponding to the consensus sequence of SEQ ID NO: 1, the mutated PTE including the at least one mutation chosen amongst 53 putative positions and the mutated PTE having enhanced properties. Also provided are compositions including the mutated hyperthermophilic PTE and the uses thereof, notably as bioscavenger of organophosphate compounds or as quorum quencher of the bacteria using lactones to communicate.
    Type: Application
    Filed: April 14, 2014
    Publication date: April 28, 2016
    Inventors: Eric CHABRIERE, Mikael ELIAS, Julien HIBLOT, Didier RAOULT
  • NOVEL ANTIVIRAL AGENT
    Publication number: 20120035098
    Abstract: The present invention describes the use of a composition including or constituted by at least one element chosen from: a specific protein including or consisting of the amino acid sequence SEQ ID NO: 5, and a protein homologous to the specific protein, for the preparation of a medicament intended for the prevention or treatment of pathologies associated with a viral infection or an inflammation.
    Type: Application
    Filed: March 4, 2010
    Publication date: February 9, 2012
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE LA MEDITERRANEE, UNIVERSITE DE STRASBOURG
    Inventors: Eric Chabriere, Mikael Elias, Olivier Rohr, Christian Schwartz