Abstract: Phenotyping of cells involves loading a biological sample into a microfluidic device (1, 100) comprising cell compartments (20, 120) to capture biological material, including target cells, in the sample in the cell compartments (20, 120). A subset (20A) of the cell compartments (20, 120) is identified as comprising target cells exhibiting target phenotype characteristic(s) as determined based on monitoring biological material in the cell compartments (20, 120) prior to addition of a test agent. The biological material is exposed to a test agent and a phenotypic response of the target cells to the test agent is determined based on monitoring target cells in the identified subset (20A) of the cell compartments (20, 120). The phenotyping of the target cells is thereby not overshadowed by the response of other cells and non-cell material present in the biological sample.

Abstract: A sample loading cartridge (1) for a microfluidic device comprises a cartridge body (10) with a sample reservoir (20) configured to house a volume of a liquid sample (3) and a sample port (30) in connection with the sample reservoir (20). The cartridge (1) also comprises an output channel (40) extending from the sample reservoir (20) and a feedback channel (50) connected to the sample reservoir (20) and to the sample port (30). The cartridge body (10) comprises a detection portion (60) aligned with the feedback channel (50) to enable detection of any sample (3) in the feedback channel (50). The flow resistance of the feedback channel (50) is lower than the flow resistance of the output channel (40) to cause liquid sample (3) received in the sample port (30) to enter the feedback channel (50) with substantially no liquid sample (3) entering the output channel (40).

Abstract: A microfluidic device (1) comprises a substrate (10) having a flow input channel (30) in fluid connection with a first fluid port (31) and a flow output channel (40) in fluid connection with a third fluid port (41) and cell channels (20) disposed between the flow input channel (30) and the flow output channel (40). The cell channels (20) comprise a respective obstruction (25) designed to prevent the target cells from passing the respective obstruction (25) and into the flow output channel (40). The microfluidic device (1) also comprises a pre-filter (50) with a filter channel (60) in fluid connection with a first filter port (61) and pre-filter channels (70) adapted to accommodate the target cells. A respective first end (72) of the pre-filter channels (70) is in fluid connection with the filter channel (60) and a respective second end (74) of the pre-filter channels (70) is in fluid connection with the flow input channel (30).

Abstract: A cartridge comprises a chip chamber configured to house a microfluidic chip comprising a plurality of sets of cell channels configured to capture cells from a biological sample. The cartridge also comprises a sample chamber configured to receive the biological sample and be in fluid connection with the plurality of sets of cell channels and a plurality of medium reservoirs. Each medium reservoir of the plurality of medium reservoirs is configured to be in fluid connection with a respective set of cell channels of the plurality of sets of cell channels. The cartridge further comprises culture medium source in fluid connection with the plurality of medium reservoirs and configured to supply a culture medium to the plurality of medium reservoirs.

Abstract: A method and a system for inductively programming a fuze including at least one target coil arranged in a projectile by a fuze setter including at least one setter coil, the method including i) conveying at least one of a projectile or a fuze setter by an actuator to bring the at least one target coil and the at least one setter coil in an inductive coupling position, ii) programming the fuze by transferring predetermined fuzing data from the at least one setter coil to the at least one target coil, iii) optionally transferring fuzing data from the at least one target coil to the at least one setter coil to confirm correct programming of the fuze has been performed, and iv) retracting at least one of the fuze setter or projectile from the inductive coupling position when the transfer of fuzing data has been completed.

Abstract: A sample loading cartridge (1) for a microfluidic device comprises a cartridge body (10) with a sample reservoir (20) configured to house a volume of a liquid sample (3) and a sample port (30) in connection with the sample reservoir (20). The cartridge (1) also comprises an output channel (40) extending from the sample reservoir (20) and a feedback channel (50) connected to the sample reservoir (20) and to the sample port (30). The cartridge body (10) comprises a detection portion (60) aligned with the feedback channel (50) to enable detection of any sample (3) in the feedback channel (50). The flow resistance of the feedback channel (50) is lower than the flow resistance of the output channel (40) to cause liquid sample (3) received in the sample port (30) to enter the feedback channel (50) with substantially no liquid sample (3) entering the output channel (40).

Abstract: A method and a system for inductively programming a fuze including at least one target coil arranged in a projectile by a fuze setter including at least one setter coil, the method including i) conveying at least one of a projectile or a fuze setter by an actuator to bring the at least one target coil and the at least one setter coil in an inductive coupling position, ii) programming the fuze by transferring predetermined fuzing data from the at least one setter coil to the at least one target coil, iii) optionally transferring fuzing data from the at least one target coil to the at least one setter coil to confirm correct programming of the fuze has been performed, and iv) retracting at least one of the fuze setter or projectile from the inductive coupling position when the transfer of fuzing data has been completed.

Abstract: A method and a system for inductively programming a fuze including at least one target coil arranged in a projectile by a fuze setter including at least one setter coil, the method including i) conveying at least one of a projectile or a fuze setter by an actuator to bring the at least one target coil and the at least one setter coil in an inductive coupling position, ii) programming the fuze by transferring predetermined fuzing data from the at least one setter coil to the at least one target coil, iii) optionally transferring fuzing data from the at least one target coil to the at least one setter coil to confirm correct programming of the fuze has been performed, and iv) retracting at least one of the fuze setter or projectile from the inductive coupling position when the transfer of fuzing data has been completed.

Abstract: A combination of components in a capillary flow channel use capillary forces to passively control the movement of liquid samples within a microfluidic device. To detect a target, a liquid sample introduced to a proximal portion of capillary channel of a microfluidic device moves by capillary action along the specific components of capillary channel.

Abstract: A capturing of target cells from a biological sample is achieved by inducing a flow of the biological sample in a flow channel (30, 60) of an upstream microfluidic device (1). Target cells present in the biological sample are captured in cell channels (20) of the upstream microfluidic device(1). Once at least a minimum number of target cells are captured in the cell channels (20), the flow of the biological sample in the flow channel is reduced and are verse flow is applied at the upstream microfluidic device (1) to release the target cells captured in the cell channels (20) of the upstream microfluidic device (1) and enable transfer the target cells into cell channels (120) of a downstream microfluidic device (100).

Abstract: A microfluidic device (1) comprises a substrate (10) having a flow input channel (30) in fluid connection with a first fluid port (31) and a flow output channel (40) in fluid connection with a third fluid port (41) and cell channels (20) disposed between the flow input channel (30) and the flow output channel (40). The cell channels (20) comprise a respective obstruction (25) designed to prevent the target cells from passing the respective obstruction (25) and into the flow output channel (40). The microfluidic device (1) also comprises a pre-filter (50) with a filter channel (60) in fluid connection with a first filter port (61) and pre-filter channels (70) adapted to accommodate the target cells. A respective first end (72) of the pre-filter channels (70) is in fluid connection with the filter channel (60) and a respective second end (74) of the pre-filter channels (70) is in fluid connection with the flow input channel (30).

Abstract: A combination of components in a capillary flow channel use capillary forces to passively control the movement of liquid samples within a microfluidic device. To detect a target, a liquid sample introduced to a proximal portion of a capillary channel of a microfluidic device moves by capillary action along the specific components of capillary channel.

Abstract: A method and a system for inductively programming a fuze including at least one target coil arranged in a projectile by a fuze setter including at least one setter coil, the method including i) conveying at least one of a projectile or a fuze setter by an actuator to bring the at least one target coil and the at least one setter coil in an inductive coupling position, ii) programming the fuze by transferring predetermined fuzing data from the at least one setter coil to the at least one target coil, iii) optionally transferring fuzing data from the at least one target coil to the at least one setter coil to confirm correct programming of the fuze has been performed, and iv) retracting at least one of the fuze setter or projectile from the inductive coupling position when the transfer of fuzing data has been completed.

Abstract: Phenotyping of cells involves loading a biological sample into a microfluidic device (1, 100) comprising cell compartments (20, 120) to capture biological material, including target cells, in the sample in the cell compartments (20, 120). A subset (20A) of the cell compartments (20, 120) is identified as comprising target cells exhibiting target phenotype characteristic(s) as determined based on monitoring biological material in the cell compartments (20, 120) prior to addition of a test agent. The biological material is exposed to a test agent and a phenotypic response of the target cells to the test agent is determined based on monitoring target cells in the identified subset (20A) of the cell compartments (20, 120). The phenotyping of the target cells is thereby not overshadowed by the response of other cells and non-cell material present in the biological sample.

Abstract: A combination of components in a capillary flow channel use capillary forces to passively control the movement of liquid samples within a microfluidic device. To detect a target, a liquid sample introduced to a proximal portion of a capillary channel of a microfluidic device moves by capillary action along the specific components of capillary channel.

Abstract: A digital scoreboard system and method for public posting of exercise scores using a digital scoreboard is described herein. The method comprises receiving at least one exercise score from a user and at least one further exercise score from a further user. The exercise score and the further exercise score are processed and posted together with the processing data via a digital scoreboard display device. The digital scoreboard display device is publicly disposed on a premise associated with a sport club. The user and the further user are provided access to the exercise scores and the processing data.

Abstract: The present invention relates to methods for joining materials as well as articles manufactured using such processes. The invention pertains to a process for joining a first substrate to a second substrate. The process includes irradiating a portion of a first substrate with a laser beam having a first wavelength and intensity sufficient to increase the absorbance of the first substrate to light having a second, different wavelength. The laser beam may carbonize at least a portion of the irradiated portion of the first substrate imparting a higher absorbance to light than non-irradiated portions of the first substrate. A second substrate is then placed in contact with the irradiated portion of the first substrate. The first substrate is then irradiated with a second laser having a second wavelength, different to the first wavelength; with a sufficient intensity to heat and, preferably melt, the irradiated portion of the first substrate.