Patents by Inventor Mike Alan Clark

Mike Alan Clark has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Alkyl or olefinic endcapped polyalkylene oxide solubilizer
    Patent number: 6013283
    Abstract: A method for rendering water-insoluble materials water-soluble is provided. The method is useful for solubilizing substantially water-insoluble bioactive materials such as drugs. This is accomplished by forming a non-covalently bonded complex between the drug and a polymer which is soluble in both water and an organic solvent. This is carried out by combining the desired medicinal agent with the polymer is an organic solvent, removing the solvent and dissolving the complex in water or aqueous buffer. When the organic solvent is evaporated, a solid complex is recovered which is water-soluble. Methods of treatment with the complexes are also provided.
    Type: Grant
    Filed: July 21, 1997
    Date of Patent: January 11, 2000
    Assignee: Enzon Inc.
    Inventors: Richard B. Greenwald, Robert G. L. Shorr, Mike Alan Clark, Alahari Arunakumari
  • Water soluble complex of an alkyl or olefinic end capped polyalkylene oxide and a water insoluble substance
    Patent number: 5686110
    Abstract: A method for rendering water-insoluble materials water-soluble is provided. The method is useful for solubilizing substantially water-insoluble bioactive materials such as drugs. This is accomplished by forming a non-covalently bonded complex between the drug and a polyalkylene oxide polymer end capped with an alkyl or olefinic group which is soluble in both water and an organic solvent. This is carried out by combining the desired medicinal agent with the polymer is an organic solvent, removing the solvent and dissolving the complex in water or aqueous buffer. When the organic solvent is evaporated, a solid complex is recovered which is water-soluble. Methods of treatment with the complexes are also provided.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: November 11, 1997
    Assignee: Enzon, Inc.
    Inventors: Richard B. Greenwald, Robert G. L. Shorr, Mike Alan Clark, Alahari Arunakumari