Abstract: Methods and apparatus provide a therapeutic fluid to devices implanted in the body, for example to containers of devices implanted in the eye of a patient. The methods and apparatus may comprise an injector to increase an amount of therapeutic agent injected into the device implanted in the eye, or a structure to receive the therapeutic fluid within the device implanted in the eye, or combinations thereof. The device implanted in the eye may comprise a reservoir chamber having a fluid with a density different than the therapeutic fluid, and the apparatus can be adapted to at least partially separate the implanted device fluid from therapeutic fluid within the reservoir chamber to increase and amount of therapeutic fluid placed in the reservoir chamber.

Abstract: A method includes generating, by an asset modification module, a core algorithm for modification of assets. The core algorithm modifies the assets based on time-sensitive and time varying evaluation data and in accordance with user preferences. For an asset of the assets, the method further comprises generating a set of augmented algorithms based on the core algorithm, where the set of augmented algorithms modifies the asset based on asset specific time-sensitive and time varying evaluation data and in accordance with asset specific user preferences. When the asset is selected for modification, the method further includes obtaining current asset specific time-sensitive and time varying evaluation data and selecting an augmented algorithm to process indicators of the current asset specific time-sensitive and time varying evaluation data in light of the asset specific user preferences to determine a modification operation.

Abstract: An injector apparatus comprises an elongate structure having one or more openings positionable near a penetrable barrier of an implantable device so as to receive fluid of the implantable device. The apparatus comprises a needle and a sheath extending over at least a portion of the needle. The elongate structure may comprise a distal tip to penetrate tissue and the penetrable barrier, and a distal opening near the tip to release therapeutic fluid into the implantable chamber. In many embodiments the distal tip, the distal opening, and the plurality of openings are separated from a stop that engages a tissue of the patient and limit penetration depth such that the distal opening and the plurality of openings are located along an axis of the implantable device to increase an efficiency of the exchange.

Abstract: A method includes generating, by an asset modification module, a core algorithm for modification of assets. The core algorithm modifies the assets based on time-sensitive and time varying evaluation data and in accordance with user preferences. For an asset of the assets, the method further comprises generating a set of augmented algorithms based on the core algorithm, where the set of augmented algorithms modifies the asset based on asset specific time-sensitive and time varying evaluation data and in accordance with asset specific user preferences. When the asset is selected for modification, the method further includes obtaining current asset specific time-sensitive and time varying evaluation data and selecting an augmented algorithm to process indicators of the current asset specific time-sensitive and time varying evaluation data in light of the asset specific user preferences to determine a modification operation.

Abstract: An inventory modification device includes memory, an inventory modification module, and operation modules. The memory stores limit tables and inventory operational data. The inventory modification module selects an inventory item to modify, a limit table regarding the inventory item, an operational module based on an entry in the limit table, and evaluation data. A specific task execution module of the selected operation module executes a specific task on inventory operational data of the inventory item to produce a modified inventory item when an evaluation data filter of the selected operation module indicates that analysis of the evaluation data is favorable for modification of the inventory item via the specific task.

Abstract: A device includes a network interface module, memory, and a processing module. The memory stores limit tables regarding an asset and operational data regarding the asset. When an asset is to be modified, the processing module retrieves a limit table(s) and identifies time-varying and time-sensitive data and an operation therefrom. The processing module then receives, via the network interface module, the time-varying and time-sensitive data and analyzes it based on evaluation criteria in the limit table. When the analysis is favorable, the processing module triggers the operation. With the operation triggered, the processing module further analyzes the time-varying and time-sensitive data based on correlated evaluation criteria of the evaluation criteria. When the further analysis is favorable, the processing module activates the operation for execution up operational data regarding the asset such that the asset is modified.

Abstract: Methods and apparatus provide a therapeutic fluid to devices implanted in the body, for example to containers of devices implanted in the eye of a patient. The methods and apparatus may comprise an injector to increase an amount of therapeutic agent injected into the device implanted in the eye, or a structure to receive the therapeutic fluid within the device implanted in the eye, or combinations thereof. The device implanted in the eye may comprise a reservoir chamber having a fluid with a density different than the therapeutic fluid, and the apparatus can be adapted to at least partially separate the implanted device fluid from therapeutic fluid within the reservoir chamber to increase and amount of therapeutic fluid placed in the reservoir chamber.

Abstract: Methods and apparatus provide a therapeutic fluid to devices implanted in the body, for example to containers of devices implanted in the eye of a patient. The methods and apparatus may comprise an injector to increase an amount of therapeutic agent injected into the device implanted in the eye, or a structure to receive the therapeutic fluid within the device implanted in the eye, or combinations thereof. The device implanted in the eye may comprise a reservoir chamber having a fluid with a density different than the therapeutic fluid, and the apparatus can be adapted to at least partially separate the implanted device fluid from therapeutic fluid within the reservoir chamber to increase and amount of therapeutic fluid placed in the reservoir chamber.

Abstract: An injector apparatus comprises an elongate structure having one or more openings positionable near a penetrable barrier of an implantable device so as to receive fluid of the implantable device. The apparatus comprises a needle and a sheath extending over at least a portion of the needle. The elongate structure may comprise a distal tip to penetrate tissue and the penetrable barrier, and a distal opening near the tip to release therapeutic fluid into the implantable chamber. In many embodiments the distal tip, the distal opening, and the plurality of openings are separated from a stop that engages a tissue of the patient and limit penetration depth such that the distal opening and the plurality of openings are located along an axis of the implantable device to increase an efficiency of the exchange.

Abstract: Described herein is an apparatus to insert an implantable therapeutic device into a patient. The apparatus includes a proximal handle (210) and a distal placement portion (220) coupled to the proximal handle and configured to hold the implantable therapeutic device. The distal placement portion includes a first side (222) having a first engagement structure (251) at a distal end of the first side, the first engagement structure configured to surround at least a first portion of a proximal end region of the implantable therapeutic device. The distal placement portion includes a second, opposite side (224) having a second engagement structure (253) at a distal end of the second side, the second engagement structure configured to surround at least a second, opposite portion of the proximal end region of the implantable therapeutic device.

Abstract: Methods and apparatus provide a therapeutic fluid to devices implanted in the body, for example to containers of devices implanted in the eye of a patient. The methods and apparatus may comprise an injector to increase an amount of therapeutic agent injected into the device implanted in the eye, or a structure to receive the therapeutic fluid within the device implanted in the eye, or combinations thereof. The device implanted in the eye may comprise a reservoir chamber having a fluid with a density different than the therapeutic fluid, and the apparatus can be adapted to at least partially separate the implanted device fluid from therapeutic fluid within the reservoir chamber to increase and amount of therapeutic fluid placed in the reservoir chamber.

Abstract: An injector apparatus comprises an elongate structure having one or more openings positionable near a penetrable barrier of an implantable device so as to receive fluid of the implantable device. The apparatus comprises a needle and a sheath extending over at least a portion of the needle. The elongate structure may comprise a distal tip to penetrate tissue and the penetrable barrier, and a distal opening near the tip to release therapeutic fluid into the implantable chamber. In many embodiments the distal tip, the distal opening, and the plurality of openings are separated from a stop that engages a tissue of the patient and limit penetration depth such that the distal opening and the plurality of openings are located along an axis of the implantable device to increase an efficiency of the exchange.

Abstract: Methods and apparatus provide a therapeutic fluid to devices implanted in the body, for example to containers of devices implanted in the eye of a patient. The methods and apparatus may comprise an injector to increase an amount of therapeutic agent injected into the device implanted in the eye, or a structure to receive the therapeutic fluid within the device implanted in the eye, or combinations thereof. The device implanted in the eye may comprise a reservoir chamber having a fluid with a density different than the therapeutic fluid, and the apparatus can be adapted to at least partially separate the implanted device fluid from therapeutic fluid within the reservoir chamber to increase and amount of therapeutic fluid placed in the reservoir chamber.

Abstract: Methods and apparatus provide a therapeutic fluid to devices implanted in the body, for example to containers of devices implanted in the eye of a patient. The methods and apparatus may comprise an injector to increase an amount of therapeutic agent injected into the device implanted in the eye, or a structure to receive the therapeutic fluid within the device implanted in the eye, or combinations thereof. The device implanted in the eye may comprise a reservoir chamber having a fluid with a density different than the therapeutic fluid, and the apparatus can be adapted to at least partially separate the implanted device fluid from therapeutic fluid within the reservoir chamber to increase and amount of therapeutic fluid placed in the reservoir chamber.

Abstract: Methods and apparatus provide a therapeutic fluid to devices implanted in the body, for example to containers of devices implanted in the eye of a patient. The methods and apparatus may comprise an injector to increase an amount of therapeutic agent injected into the device implanted in the eye, or a structure to receive the therapeutic fluid within the device implanted in the eye, or combinations thereof. The device implanted in the eye may comprise a reservoir chamber having a fluid with a density different than the therapeutic fluid, and the apparatus can be adapted to at least partially separate the implanted device fluid from therapeutic fluid within the reservoir chamber to increase and amount of therapeutic fluid placed in the reservoir chamber.

Abstract: Described herein is an apparatus to insert an implantable therapeutic device into a patient. The apparatus includes a proximal handle (210) and a distal placement portion (220) coupled to the proximal handle and configured to hold the implantable therapeutic device. The distal placement portion includes a first side (222) having a first engagement structure (251) at a distal end of the first side, the first engagement structure configured to surround at least a first portion of a proximal end region of the implantable therapeutic device. The distal placement portion includes a second, opposite side (224) having a second engagement structure (253) at a distal end of the second side, the second engagement structure configured to surround at least a second, opposite portion of the proximal end region of the implantable therapeutic device.

Abstract: A system and method of joining workpieces is provided where a clad layer is deposited in between the components and a weld bead is providing such that it contacts the clad layer. The system and method provided minimizes the heat input into the components by using the clad layers to provide the joining strength between the pipe components.

Abstract: A system and method for narrow groove welding is provided. The system includes at least one laser emitting a laser beam to heat at least one of a first workpiece and a second workpiece to create at least one molten puddle. The system also includes at least one wire feeder feeding at least one wire to the at least one molten puddle. An edge of the first workpiece and an edge of the second workpiece are configured such that an alignment of the workpieces forms a first groove and a second groove. The first groove and the second groove are formed on opposite sides of the workpieces. For each groove, its depth is 50% to 75% of a thickness of the first workpiece or the second workpiece, a gap width at a surface of the workpieces is 1.5 to 2 times a diameter of the at least one wire, and a sidewall angle is a range of 0.5 to 10 degrees with respect to a centerline of the respective groove.