Patents by Inventor Mike M. Y. Chen

Mike M. Y. Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ALKANE OXIDATION BY MODIFIED HYDROXYLASES
    Publication number: 20220112524
    Abstract: This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells.
    Type: Application
    Filed: December 23, 2021
    Publication date: April 14, 2022
    Inventors: Frances Arnold, Peter Meinhold, Matthew W. Peters, Rudi Fasan, Mike M.Y. Chen
  • Alkane oxidation by modified hydroxylases
    Patent number: 11214817
    Abstract: This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells.
    Type: Grant
    Filed: May 11, 2020
    Date of Patent: January 4, 2022
    Assignee: California Institute of Technology
    Inventors: Frances Arnold, Peter Meinhold, Matthew W. Peters, Rudi Fasan, Mike M. Y. Chen
  • ALKANE OXIDATION BY MODIFIED HYDROXYLASES
    Publication number: 20200399662
    Abstract: This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells.
    Type: Application
    Filed: May 11, 2020
    Publication date: December 24, 2020
    Inventors: Frances Arnold, Peter Meinhold, Matthew W. Peters, Rudi Fasan, Mike M.Y. Chen
  • Alkane oxidation by modified hydroxylases
    Patent number: 10648006
    Abstract: This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: May 12, 2020
    Assignee: California Institute of Technology
    Inventors: Frances Arnold, Peter Meinhold, Matthew W. Peters, Rudi Fasan, Mike M. Y. Chen
  • Synthesis of olefinic alcohols via enzymatic terminal hydroxylation
    Patent number: 10202620
    Abstract: In certain aspects, the present invention provides methods for producing terminally hydroxylated alkenes and alkynes by contacting an unsaturated or saturated hydrocarbon substrate with a hydroxylase enzyme. Exemplary terminal hydroxylases useful for carrying out the methods of the invention exhibit strong selectivity towards one terminal carbon of a hydrocarbon substrate and include, but are not limited to, non-heme diiron alkane monooxygenases, cytochromes P450 (e.g., cytochromes P450 of the CYP52 and CYP153 family), as well as long chain alkane hydroxylases. In some embodiments, the terminally hydroxylated alkene or alkyne is further converted to a terminal alkenal. In certain embodiments, terminally hydroxylated alkenes and alkynes are useful as insect pheromones which modify insect behavior. In other embodiments, terminally hydroxylated alkenes and alkynes are useful intermediates for producing pheromones via acetylation or oxidation of the alcohol moiety.
    Type: Grant
    Filed: September 3, 2015
    Date of Patent: February 12, 2019
    Assignee: PROVIVI, INC.
    Inventors: Pedro Coelho, Mike M. Y. Chen, Peter Meinhold, Catherine Mee-Hie Cho, Vu Bui, Thomas Heel
  • ALKANE OXIDATION BY MODIFIED HYDROXYLASES
    Publication number: 20180273983
    Abstract: This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells.
    Type: Application
    Filed: March 30, 2018
    Publication date: September 27, 2018
    Inventors: Frances Arnold, Peter Meinhold, Matthew W. Peters, Rudi Fasan, Mike M.Y. Chen
  • Alkane oxidation by modified hydroxylases
    Patent number: 9963720
    Abstract: This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells.
    Type: Grant
    Filed: August 1, 2016
    Date of Patent: May 8, 2018
    Assignee: California Institute of Technology
    Inventors: Frances Arnold, Peter Meinhold, Matthew W. Peters, Rudi Fasan, Mike M. Y. Chen
  • ALKANE OXIDATION BY MODIFIED HYDROXYLASES
    Publication number: 20170183689
    Abstract: This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells.
    Type: Application
    Filed: August 1, 2016
    Publication date: June 29, 2017
    Inventors: Frances Arnold, Peter Meinhold, Matthew W. Peters, Rudi Fasan, Mike M.Y. Chen
  • Synthesis of pyrethroids and pyrethroid-containing compositions
    Patent number: 9487471
    Abstract: The present invention provides methods for synthesizing pyrethroid compounds. The methods include forming a first reaction comprising an olefin and an allethrolone-type unsaturated alcohol under conditions sufficient to form a metathesis product and converting the metathesis product to the pyrethroid. Methods of the invention can be used to prepare compounds including pyrethrin I, cinerin I, jasmolin I, pyrethrin II, cinerin II, and jasmolin II as well as other synthetic pyrethroid compounds. Insecticidal compositions and methods for controlling insects are also described.
    Type: Grant
    Filed: April 14, 2015
    Date of Patent: November 8, 2016
    Assignee: PROVIVI, INC.
    Inventors: Pedro Coelho, Peter Meinhold, Mike M. Y. Chen
  • Alkane oxidation by modified hydroxylases
    Patent number: 9404096
    Abstract: This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells.
    Type: Grant
    Filed: June 30, 2015
    Date of Patent: August 2, 2016
    Assignee: California Institute of Technology
    Inventors: Frances Arnold, Peter Meinhold, Matthew W. Peters, Rudi Fasan, Mike M. Y. Chen
  • SYNTHESIS OF OLEFINIC ALCOHOLS VIA ENZYMATIC TERMINAL HYDROXYLATION
    Publication number: 20160108436
    Abstract: In certain aspects, the present invention provides methods for producing terminally hydroxylated alkenes and alkynes by contacting an unsaturated or saturated hydrocarbon substrate with a hydroxylase enzyme. Exemplary terminal hydroxylases useful for carrying out the methods of the invention exhibit strong selectivity towards one terminal carbon of a hydrocarbon substrate and include, but are not limited to, non-heme diiron alkane monooxygenases, cytochromes P450 (e.g., cytochromes P450 of the CYP52 and CYP153 family), as well as long chain alkane hydroxylases. In some embodiments, the terminally hydroxylated alkene or alkyne is further converted to a terminal alkenal. In certain embodiments, terminally hydroxylated alkenes and alkynes are useful as insect pheromones which modify insect behavior. In other embodiments, terminally hydroxylated alkenes and alkynes are useful intermediates for producing pheromones via acetylation or oxidation of the alcohol moiety.
    Type: Application
    Filed: September 3, 2015
    Publication date: April 21, 2016
    Applicant: Provivi, Inc.
    Inventors: PEDRO COELHO, Mike M.Y. Chen, Peter Meinhold, Catherine Mee-Hie Cho, Vu Bui, Thomas Heel
  • ALKANE OXIDATION BY MODIFIED HYDROXYLASES
    Publication number: 20160024482
    Abstract: This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells.
    Type: Application
    Filed: June 30, 2015
    Publication date: January 28, 2016
    Inventors: Frances Arnold, Peter Meinhold, Matthew W. Peters, Rudi Fasan, Mike M.Y. Chen
  • Alkane oxidation by modified hydroxylases
    Patent number: 9074178
    Abstract: This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells.
    Type: Grant
    Filed: May 5, 2014
    Date of Patent: July 7, 2015
    Assignee: The California Institute of Technology
    Inventors: Frances Arnold, Peter Meinhold, Matthew W. Peters, Rudi Fasan, Mike M. Y. Chen
  • ALKANE OXIDATION BY MODIFIED HYDROXYLASES
    Publication number: 20150004668
    Abstract: This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells.
    Type: Application
    Filed: May 5, 2014
    Publication date: January 1, 2015
    Applicant: The California Institute of Technology
    Inventors: Frances Arnold, Peter Meinhold, Matthew W. Peters, Rudi Fasan, Mike M.Y. Chen
  • Alkane oxidation by modified hydroxylases
    Patent number: 8715988
    Abstract: This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells.
    Type: Grant
    Filed: April 6, 2007
    Date of Patent: May 6, 2014
    Assignee: California Institute of Technology
    Inventors: Frances Arnold, Peter Meinhold, Matthew W. Peters, Rudi Fasan, Mike M. Y. Chen