Abstract: Systems and methods are provided for inducing a therapeutic state of hypothermia in a patient. Cold biocompatible liquid is infused into a patient at a defined temperature and pressure and at a fairly rapid rate to quickly induce hypothermia. In one system, cold liquid is provided from a flowing source. In another, cold liquid is forced out of a refrigerated bag, the pressure on the bag arising from air pressure on the bag, an infusor cuff, or any other technique which may apply such pressure. The cold liquid may be cooled in advance of the infusion or via a cold plate which forms a portion of the system.