Abstract: Provided are novel IFB-a binding molecules of human origin, particularly human-derived anti-IFN-? antibodies as well as IFN-? binding fragments, derivatives and variants thereof. In addition, pharmaceutical compositions, kits, and methods for use in diagnosis and therapy are described.

Abstract: A therapeutic device includes a prosthetic heart valve including a collapsible and expandable stent having an aortic section and an annulus section, and a valve assembly disposed within the annulus section of the stent, the valve assembly including a plurality of leaflets; and a graft coupled to the aortic section of the stent. The graft has a body and at least one lining disposed on the body and defining a lumen therethrough.

Abstract: A therapeutic device includes a prosthetic heart valve including a collapsible and expandable stent having an aortic section and an annulus section, and a valve assembly disposed within the annulus section of the stent, the valve assembly including a plurality of leaflets; and a graft coupled to the aortic section of the stent. The graft has a body and at least one lining disposed on the body and defining a lumen therethrough.

Abstract: A catheter assembly and related methods having a main balloon, a branch balloon arrangement and a stent. The catheter assembly includes a main catheter branch, a side catheter branch arrangement, and a stent. The main catheter branch includes at least a main balloon and a side balloon. The side catheter branch arrangement includes a branch guidewire housing and a sleeve member. At least a portion of the side catheter branch arrangement extends through a proximal open end of the stent and out through a side branch aperture of the stent. The branch guidewire housing defines a side branch lumen configured to advance over a branch vessel guidewire. The sleeve member is sized to receive the branch guidewire housing, wherein the branch guidewire housing is axially movable within the sleeve member. The sleeve member is typically fixed axially relative to the main catheter branch.

Abstract: The present invention relates to a process for the production of a car interior part with a base layer and a fabric layer and a car interior part comprising these layers.

Abstract: A catheter assembly and related methods having a main balloon, a branch balloon arrangement and a stent. The catheter assembly includes a main catheter branch, a side catheter branch arrangement, and a stent. The main catheter branch includes at least a main balloon and a side balloon. The side catheter branch arrangement includes a branch guidewire housing and a sleeve member. At least a portion of the side catheter branch arrangement extends through a proximal open end of the stent and out through a side branch aperture of the stent. The branch guidewire housing defines a side branch lumen configured to advance over a branch vessel guidewire. The sleeve member is sized to receive the branch guidewire housing, wherein the branch guidewire housing is axially movable within the sleeve member. The sleeve member is typically fixed axially relative to the main catheter branch.

Abstract: The invention relates to a medical device, such as an intravascular stent, useful for delivering two or more therapeutic agents to a body tissue of a patient at different rates, and methods for making and using such medical device. The medical device includes a substrate and/or coating having a plurality of pores, dispersed in said pores are a plurality of a first and second therapeutic agents, wherein said first therapeutic agent is bonded to one or more molecule(s) of a first material and the second therapeutic agent bonded to one or more molecule(s) of a second material, such that when the medical device, is in use (e.g., implanted into a body lumen such as a blood vessel), bonded first therapeutic agent is released from the medical device at a rate that is slower than the rate at which the bonded second therapeutic agent is released from the medical device.

Abstract: The invention includes a marine telematics system comprising a satcom unit on a boat, a user interface for the satcom unit, a web-based user interface for the telematics system, and a land-based center of operations. The land-based center of operations receives signals from the satcom unit on the boat about the location of the boat and sensor responses to detectable events. The marine telematics system is customizable through a web-based interface, allowing boat owners to provide information and instructions to the land-based center of operations for handling particular situations that may arise while the boat is in use or at dock. The web-based interface further allows boat owners to plan voyages by setting series of waypoints, and the land-based center of operations may assist the boat owners by providing feedback during their voyages based on the waypoint information previously provided by the boat owners.