Abstract: An endpoint in a network may make posted or non-posted write requests to another endpoint in the network. For a non-posted write request, the target endpoint provides a response to the requesting endpoint indicating that the write request has been serviced. For a posted write request, the target endpoint does not provide such an acknowledgment. Hence, posted write requests have lower overhead, but they suffer from potential synchronization and resiliency issues. While non-posted write requests do not have those issues, they cause increased load on the network because such requests require the target endpoint to acknowledge each write request. Introduced herein is a network operation technique that uses non-posted transactions while maintaining a load overhead of the network as a manageable level. The introduced technique reduces the load overhead of the non-posted write requests by collapsing and reducing a number of the responses.

Abstract: An endpoint in a network may make posted or non-posted write requests to another endpoint in the network. For a non-posted write request, the target endpoint provides a response to the requesting endpoint indicating that the write request has been serviced. For a posted write request, the target endpoint does not provide such an acknowledgment. Hence, posted write requests have lower overhead, but they suffer from potential synchronization and resiliency issues. While non-posted write requests do not have those issues, they cause increased load on the network because such requests require the target endpoint to acknowledge each write request. Introduced herein is a network operation technique that uses non-posted transactions while maintaining a load overhead of the network as a manageable level. The introduced technique reduces the load overhead of the non-posted write requests by collapsing and reducing a number of the responses.

Abstract: Human or chimeric heavy chain-only antibodies are provided, in the native amino acid residue at the first position of the fourth framework region (FR4) of said HCAb is substituted by a different amino acid residue that is capable of disrupting a surface-exposed hydrophobic patch comprising or associated with the native amino acid residue at that position.

Abstract: A CRC generator, a method for computing a CRC of a data packet, and an electronic system, such as a circuit board, are disclosed herein. In one embodiment the method is for computing the CRC of a data packet to be transmitted on a serial communications link having multiple lanes. In one embodiment, the CRC generator includes: (1) a CRC calculator configured to define a CRC calculation of a data packet in sequential order and perform parallelized computations, according to the sequential order and the multiple lanes, to generate sub-CRC values and (2) combination circuitry configured to combine the sub-CRC values to provide the CRC value for the packet.

Abstract: Remotely synchronizing data communicated in an electronic computing system. Ordered writing of a data set of discrete data packets (data) and a following associated semaphore packet (semaphore) from a source electronic device (source) to a bridge interface device (bridge). Relaxed writing of the data set from the bridge to discrete target memory addresses (targets) of a data-consuming electronic device (consumer), wherein the order of the data and the semaphore written to the targets is different than the order of the data and semaphore written with the ordered writing. Monitoring, by the consumer, the relaxed writing of the semaphore to one of the targets. Issuing a synchronization command to the bridge upon detection of the semaphore having been written to the one target. Sending a synchronization confirmation reply from the bridge after all of the data has been written to the targets.

Abstract: Remotely synchronizing data communicated in an electronic computing system. Ordered writing of a data set of discrete data packets (data) and a following associated semaphore packet (semaphore) from a source electronic device (source) to a bridge interface device (bridge). Relaxed writing of the data set from the bridge to discrete target memory addresses (targets) of a data-consuming electronic device (consumer), wherein the order of the data and the semaphore written to the targets is different than the order of the data and semaphore written with the ordered writing. Monitoring, by the consumer, the relaxed writing of the semaphore to one of the targets. Issuing a synchronization command to the bridge upon detection of the semaphore having been written to the one target. Sending a synchronization confirmation reply from the bridge after all of the data has been written to the targets.

Abstract: A CRC generator, a method for computing a CRC of a data packet, and an electronic system, such as a circuit board, are disclosed herein. In one embodiment the method is for computing the CRC of a data packet to be transmitted on a serial communications link having multiple lanes. In one embodiment, the CRC generator includes: (1) a CRC calculator configured to define a CRC calculation of a data packet in sequential order and perform parallelized computations, according to the sequential order and the multiple lanes, to generate sub-CRC values and (2) combination circuitry configured to combine the sub-CRC values to provide the CRC value for the packet.