Patents by Inventor Mike Tyers

Mike Tyers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for treating a brain cancer with ifenprodil
    Patent number: 8058243
    Abstract: A clonogenic neurosphere assay is described that carries out high throughput screens (HTS) to identify potent and/or selective modulators of proliferation, differentiation and/or renewal of neural precursor cells, neural progenitor cells and/or self-renewing and multipotent neural stem cells (NSCs). Compositions comprising the identified modulators and methods of using the modulators and compositions, in particular to treat neurological disorders (e.g. brain or CNS cancer) or damage are also disclosed.
    Type: Grant
    Filed: October 12, 2007
    Date of Patent: November 15, 2011
    Assignees: HSC Research and Development Limited Partnership, Mount Sinai Hospital
    Inventors: Mike Tyers, Phedias Diamandis, Peter B. Dirks
  • METHODS FOR TREATING NEUROLOGICAL DISORDERS OR DAMAGE
    Publication number: 20090076019
    Abstract: A clonogenic neurosphere assay is described that carries out high throughput screens (HTS) to identify potent and/or selective modulators of proliferation, differentiation and/or renewal of neural precursor cells, neural progenitor cells and/or self-renewing and multipotent neural stem cells (NSCs). Compositions comprising the identified modulators and methods of using the modulators and compositions, in particular to treat neurological disorders (e.g. brain or CNS cancer) or damage are also disclosed.
    Type: Application
    Filed: October 12, 2007
    Publication date: March 19, 2009
    Applicants: Mount Sinai Hospital, HSC Research and Development Limited Partnership
    Inventors: Mike Tyers, Phedias Diamandis, Peter B. Dirks
  • Structures of substrate binding pockets of SCF complexes
    Publication number: 20040171074
    Abstract: The present invention relates to binding pockets of Skp1-Cdc53/Cullin-F-box protein (SCF) E3 ubiquitin ligases associated with substrate selection and/or orientation. In particular, the invention relates to a crystal comprising such binding pockets. The crystal may be useful for modeling and/or synthesizing mimetics of a binding pocket or ligands that associate with the binding pocket. Such mimetics or ligands may be capable of acting as modulators of the interactions of a SCF E3 ubiquitin ligase and its substrates, and they may be useful for treating, inhibiting, or preventing diseases modulated by such interactions. Methods are also provided for regulating a SCF E3 ubiquitin ligase comprising changing a binding pocket associated with substrate selection and/or orientation.
    Type: Application
    Filed: October 17, 2003
    Publication date: September 2, 2004
    Applicant: MOUNT SINAI HOSPITAL
    Inventors: Stephen Orlicky, Frank Sicheri, Mike Tyers, Andrew Willems, XiaoJing Tang
  • Methods and compositions for modulating ubiquitin dependent proteolysis
    Publication number: 20030003564
    Abstract: The invention relates to methods and compositions for modulating ubiquitin dependent proteolysis.
    Type: Application
    Filed: January 29, 2002
    Publication date: January 2, 2003
    Applicant: Mount Sinai Hospital Corporation
    Inventors: Mike Tyers, Andrew Willems
  • Methods and compositions for modulating ubiquitin dependent proteolysis
    Patent number: 6426205
    Abstract: The invention relates to methods and compositions for modulating ubiquitin dependent proteolysis.
    Type: Grant
    Filed: October 22, 1998
    Date of Patent: July 30, 2002
    Assignee: Mount Sinai Hospital Corporation
    Inventors: Mike Tyers, Andrew Willems