Patents by Inventor Mikeljon P. Nikolich

Mikeljon P. Nikolich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Live vaccine against Brucellosis
    Patent number: 6444445
    Abstract: Live Brucella vaccines and methods for preparing the live vaccines protective against brucellosis are described. The vaccines are prepared by introducing a deletion in the rfbU gene of a strain of Brucella which results in attenuation of the strain while retaining the desired immunogenicity to initiate a protective immunogenic response. Other strains with varying levels of attenuation are described.
    Type: Grant
    Filed: January 22, 1998
    Date of Patent: September 3, 2002
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Mikeljon P. Nikolich, David L. Hoover, Richard L. Warren, Luther E. Lindler, Ted L. Hadfield, Gerhardt G. Schurig, Stephen M. Boyle, John R. McOulston, Nammalwar Sriranganathan
  • LIVE VACCINE AGAINST BRUCELLOSIS
    Publication number: 20010014673
    Abstract: Live Brucella vaccines and methods for preparing the live vaccines protective against brucellosis are described. The vaccines are prepared by introducing a deletion in the rfbU gene of a strain of Brucella which results in attenuation of the strain while retaining the desired immunogenicity to initiate a protective immunogenic response. Other strains with varying levels of attenuation are described.
    Type: Application
    Filed: January 22, 1998
    Publication date: August 16, 2001
    Inventors: MIKELJON P. NIKOLICH, DAVID L. HOOVER, RICHARD L. WARREN, LUTHER E. LINDLER, TED L. HADFIELD, CERHARDT G. SCHURIG, STEPHEN M. BOYLE, JOHN R. MCOULSTON, NAMMALWAR SRIRANGANATHAN
  • Method and materials for introducing DNA into Prevotella ruminicola
    Patent number: 5674733
    Abstract: A method of introducing expressible heterologous DNA into Prevotella ruminicola is provided. The method involves conjugal transfer of a shuttle vector comprising the heterologous DNA operatively linked to a promoter functional in P. ruminicola. The invention also provides shuttle vectors for use in the method and P. ruminicola produced by the method. The invention further provides a tetracycline resistance gene of the TetQ class, or fragments thereof that confer tetracycline resistance, and a protein of the TetQ class that provides resistance to tetracycline by protecting ribosomes from tetracycline, or active fragments thereof. Finally, the invention provides a promoter functional in P. ruminicola and an engineered P. ruminicola comprising expressible foreign DNA.
    Type: Grant
    Filed: December 2, 1993
    Date of Patent: October 7, 1997
    Assignee: Biotechnology Research and Development Corporation
    Inventors: Abigail A. Salyers, Nadja B. Shoemaker, Mikeljon P. Nikolich
  • Method and materials for introducing DNA into Prevotella ruminicola
    Patent number: 5322784
    Abstract: A method of introducing expressible heterologous DNA into Prevotella ruminicola is provided. The method involves conjugal transfer of a shuttle vector comprising the heterologous DNA operatively linked to a promoter functional in P. ruminicola. The invention also provides shuttle vectors for use in the method and P. ruminicola produced by the method. The invention further provides a tetracycline resistance gene of the TetQ class, or fragments thereof that confer tetracycline resistance, and a protein of the TetQ class that provides resistance to tetracycline by protecting ribosomes from tetracycline, or active fragments thereof. Finally, the invention provides a promoter functional in P. ruminicola and an engineered P. ruminicola comprising expressible foreign DNA.
    Type: Grant
    Filed: June 5, 1991
    Date of Patent: June 21, 1994
    Assignees: The Board of Trustees of the University of Illinois, Urbana-Champaign, Illinois, Biotechnology Research and Development Corporation
    Inventors: Abigail A. Salyers, Nadja B. Shoemaker, Mikeljon P. Nikolich