Patents by Inventor Mikhail A Monastyrskiy
Mikhail A Monastyrskiy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9620350Abstract: A method of reflecting ions in a multireflection time of flight mass spectrometer is disclosed. The method includes guiding ions toward an ion mirror having multiple electrodes, and applying a voltage to the ion mirror electrodes to create an electric field that causes the mean trajectory of the ions to intersect a plane of symmetry of the ion mirror and to exit the ion mirror, wherein the ion are spatially focussed by the mirror to a first location and temporally focused to a second location different from the first location. Apparatus for carrying out the method is also disclosed.Type: GrantFiled: April 18, 2016Date of Patent: April 11, 2017Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Alexander A. Makarov, Dmitry E. Grinfeld, Mikhail A. Monastyrskiy
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Publication number: 20160233076Abstract: A method of reflecting ions in a multireflection time of flight mass spectrometer is disclosed. The method includes guiding ions toward an ion mirror having multiple electrodes, and applying a voltage to the ion mirror electrodes to create an electric field that causes the mean trajectory of the ions to intersect a plane of symmetry of the ion mirror and to exit the ion mirror, wherein the ion are spatially focussed by the mirror to a first location and temporally focused to a second location different from the first location. Apparatus for carrying out the method is also disclosed.Type: ApplicationFiled: April 18, 2016Publication date: August 11, 2016Inventors: Alexander A. MAKAROV, Dmitry E. GRINFELD, Mikhail A. MONASTYRSKIY
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Patent number: 9324553Abstract: A method of reflecting ions in a multireflection time of flight mass spectrometer is disclosed. The method includes guiding ions toward an ion mirror having multiple electrodes, and applying a voltage to the ion mirror electrodes to create an electric field that causes the mean trajectory of the ions to intersect a plane of symmetry of the ion mirror and to exit the ion mirror, wherein the ion are spatially focussed by the mirror to a first location and temporally focused to a second location different from the first location. Apparatus for carrying out the method is also disclosed.Type: GrantFiled: June 24, 2015Date of Patent: April 26, 2016Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Alexander A. Makarov, Dmitry E. Grinfeld, Mikhail A. Monastyrskiy
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Publication number: 20150294849Abstract: A method of reflecting ions in a multireflection time of flight mass spectrometer is disclosed. The method includes guiding ions toward an ion mirror having multiple electrodes, and applying a voltage to the ion mirror electrodes to create an electric field that causes the mean trajectory of the ions to intersect a plane of symmetry of the ion mirror and to exit the ion mirror, wherein the ion are spatially focussed by the mirror to a first location and temporally focused to a second location different from the first location. Apparatus for carrying out the method is also disclosed.Type: ApplicationFiled: June 24, 2015Publication date: October 15, 2015Inventors: Alexander A. MAKAROV, Dmitry E. GRINFELD, Mikhail A. MONASTYRSKIY
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Patent number: 9082605Abstract: A method of reflecting ions in a multireflection time of flight mass spectrometer is disclosed. The method includes guiding ions toward an ion mirror having multiple electrodes, and applying a voltage to the ion mirror electrodes to create an electric field that causes the mean trajectory of the ions to intersect a plane of symmetry of the ion mirror and to exit the ion mirror, wherein the ion are spatially focussed by the mirror to a first location and temporally focused to a second location different from the first location. Apparatus for carrying out the method is also disclosed.Type: GrantFiled: August 2, 2013Date of Patent: July 14, 2015Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Alexander A. Makarov, Dmitry E. Grinfeld, Mikhail A. Monastyrskiy
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Patent number: 8674293Abstract: A method of reflecting ions in a multireflection time of flight mass spectrometer is disclosed. The method includes guiding ions toward an ion mirror having multiple electrodes, and applying a voltage to the ion mirror electrodes to create an electric field that causes the mean trajectory of the ions to intersect a plane of symmetry of the ion mirror and to exit the ion mirror, wherein the ion are spatially focussed by the mirror to a first location and temporally focused to a second location different from the first location. Apparatus for carrying out the method is also disclosed.Type: GrantFiled: March 8, 2013Date of Patent: March 18, 2014Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Alexander A. Makarov, Dmitry E. Grinfeld, Mikhail A. Monastyrskiy
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Publication number: 20130313424Abstract: A method of reflecting ions in a multireflection time of flight mass spectrometer is disclosed. The method includes guiding ions toward an ion mirror having multiple electrodes, and applying a voltage to the ion mirror electrodes to create an electric field that causes the mean trajectory of the ions to intersect a plane of symmetry of the ion mirror and to exit the ion mirror, wherein the ion are spatially focussed by the mirror to a first location and temporally focused to a second location different from the first location. Apparatus for carrying out the method is also disclosed.Type: ApplicationFiled: August 2, 2013Publication date: November 28, 2013Inventors: Alexander A. MAKAROV, Dmitry E. GRINFELD, Mikhail A. MONASTYRSKIY
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Patent number: 8546754Abstract: An ion trap comprises substantially elongate electrodes 10, 20 some of which are curved along their axis of elongation and which define a trapping volume between them. The sectional area of this trapping volume towards the extremities of the trap in the direction of elongation is different to the sectional area away from its extremities (eg towards the middle of the trap). In a preferred embodiment, the trap has a plurality of elongate electrodes, wherein opposed electrodes have different radii of curvature so that the trap splays towards its extremities. Thereby, a wider mass range of ions can be trapped and ejected, a higher space charge capacity (for a given trap length) is provided, and sharper ion beam focussing on ejection is possible.Type: GrantFiled: August 5, 2011Date of Patent: October 1, 2013Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Alexander A. Makarov, Mikhail A. Monastyrskiy, Dmitry E. Grinfeld
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Publication number: 20130187043Abstract: A method of reflecting ions in a multireflection time of flight mass spectrometer is disclosed. The method includes guiding ions toward an ion mirror having multiple electrodes, and applying a voltage to the ion mirror electrodes to create an electric field that causes the mean trajectory of the ions to intersect a plane of symmetry of the ion mirror and to exit the ion mirror, wherein the ion are spatially focussed by the mirror to a first location and temporally focused to a second location different from the first location. Apparatus for carrying out the method is also disclosed.Type: ApplicationFiled: March 8, 2013Publication date: July 25, 2013Inventors: Alexander A. MAKAROV, Dmitry E. GRINFIELD, Mikhail A. MONASTYRSKIY
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Patent number: 8395115Abstract: The present invention provides a method of reflecting ions in a multireflection time of flight mass spectrometer comprising providing an ion mirror having a plurality of electrodes, the ion mirror having a cross section with a first, minor axis (Y) and a second, major axis (X) each perpendicular to a longitudinal axis (Z) of the ion mirror which lies generally in the direction of time of flight separation of the ions in the mirror; guiding ions towards the ion mirror; applying a voltage to the electrodes so as to create an electric field which: (a) causes the mean trajectory of the ions to intersect a plane of symmetry of the ion mirror which contains the longitudinal (Z) and major axes (X) of the mirror; (b) causes the ions to reflect in the ion mirror; and (c) causes the ions to exit the ion mirror in a direction such that the mean trajectory of ions passing through the ion mirror has a component of movement in a direction (Y) perpendicular to and diverging from the said plane of symmetry thereof.Type: GrantFiled: December 22, 2008Date of Patent: March 12, 2013Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Alexander A. Makarov, Dmitry E. Grinfield, Mikhail A. Monastyrskiy
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Publication number: 20110284737Abstract: An ion trap comprises substantially elongate electrodes 10, 20 some of which are curved along their axis of elongation and which define a trapping volume between them. The sectional area of this trapping volume towards the extremities of the trap in the direction of elongation is different to the sectional area away from its extremities (eg towards the middle of the trap). In a preferred embodiment, the trap has a plurality of elongate electrodes, wherein opposed electrodes have different radii of curvature so that the trap splays towards its extremities. Thereby, a wider mass range of ions can be trapped and ejected, a higher space charge capacity (for a given trap length) is provided, and sharper ion beam focussing on ejection is possible.Type: ApplicationFiled: August 5, 2011Publication date: November 24, 2011Inventors: Alexander MAKAROV, Mikhail A. MONASTYRSKIY, Dmitry E. GRINFELD
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Patent number: 8017909Abstract: An ion trap comprises substantially elongate electrodes 10, 20 some of which are curved along their axis of elongation and which define a trapping volume between them. The sectional area of this trapping volume towards the extremities of the trap in the direction of elongation is different to the sectional area away from its extremities (eg towards the middle of the trap). In a preferred embodiment, the trap has a plurality of elongate electrodes, wherein opposed electrodes have different radii of curvature so that the trap splays towards its extremities. Thereby, a wider mass range of ions can be trapped and ejected, a higher space charge capacity (for a given trap length) is provided, and sharper ion beam focussing on ejection is possible.Type: GrantFiled: December 27, 2007Date of Patent: September 13, 2011Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Alexander Makarov, Mikhail A Monastyrskiy, Dmitry E. Grinfeld
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Publication number: 20110017907Abstract: The present invention provides a method of reflecting ions in a multireflection time of flight mass spectrometer comprising providing an ion mirror having a plurality of electrodes, the ion mirror having a cross section with a first, minor axis (Y) and a second, major axis (X) each perpendicular to a longitudinal axis (Z) of the ion mirror which lies generally in the direction of time of flight separation of the ions in the mirror; guiding ions towards the ion mirror; applying a voltage to the electrodes so as to create an electric field which: (a) causes the mean trajectory of the ions to intersect a plane of symmetry of the ion mirror which contains the longitudinal (Z) and major axes (X) of the mirror; (b) causes the ions to reflect in the ion mirror; and (c) causes the ions to exit the ion mirror in a direction such that the mean trajectory of ions passing through the ion mirror has a component of movement in a direction (Y) perpendicular to and diverging from the said plane of symmetry thereof.Type: ApplicationFiled: December 22, 2008Publication date: January 27, 2011Inventors: Alexander A. Makarov, Dmitry E. Grinfield, Mikhail A. Monastyrskiy
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Patent number: 7858929Abstract: A method for reducing the energy spread of ions over a specific and limited mass to charge ratio range is disclosed, along with an ion deceleration arrangement for implementing such a method. An electric field, having an electric field strength E is generated by a deceleration electrode arrangement (250). Ions of a specific and limited mass to charge ratio range, but having a spread of energies, are directed into the decelerating electric field generated by the deceleration electrode arrangement (250). The decelerating electric field is then removed, once substantially all of the ions of the specific mass to charge ratio range have entered the decelerating electric field. By matching the electric field strength E to the energy spread of the ions upon entry into the electric field, the energy spread of the said ions is reduced. Preferred embodiments of the invention employ energy dispersion upstream of the ion deceleration arrangement.Type: GrantFiled: April 13, 2007Date of Patent: December 28, 2010Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Alexander Makarov, Mikhail Monastyrskiy, Dimitry E. Grinfield
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Publication number: 20100320376Abstract: An ion trap comprises substantially elongate electrodes 10, 20 some of which are curved along their axis of elongation and which define a trapping volume between them. The sectional area of this trapping volume towards the extremities of the trap in the direction of elongation is different to the sectional area away from its extremities (eg towards the middle of the trap). In a preferred embodiment, the trap has a plurality of elongate electrodes, wherein opposed electrodes have different radii of curvature so that the trap splays towards its extremities. Thereby, a wider mass range of ions can be trapped and ejected, a higher space charge capacity (for a given trap length) is provided, and sharper ion beam focussing on ejection is possible.Type: ApplicationFiled: December 27, 2007Publication date: December 23, 2010Inventors: Alexander Makarov, Mikhail A. Monastyrskiy, Dmitry E. Grinfeld
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Publication number: 20090206248Abstract: A method for reducing the energy spread of ions over a specific and limited mass to charge ratio range is disclosed, along with an ion deceleration arrangement for implementing such a method. An electric field, having an electric field strength E is generated by a deceleration electrode arrangement (250). Ions of a specific and limited mass to charge ratio range, but having a spread of energies, are directed into the decelerating electric field generated by the deceleration electrode arrangement (250). The decelerating electric field is then removed, once substantially all of the ions of the specific mass to charge ratio range have entered the decelerating electric field. By matching the electric field strength E to the energy spread of the ions upon entry into the electric field, the energy spread of the said ions is reduced. Preferred embodiments of the invention employ energy dispersion upstream of the ion deceleration arrangement.Type: ApplicationFiled: April 13, 2007Publication date: August 20, 2009Inventors: Alexander Makarov, Mikhail Monastyrskiy, Dmitry E. Grinfield