Publication number: 20090131447
Abstract: This invention is directed to the use of SCD-1 inhibitors of the formula (I): where x, y, V, W, G, J, L, M, R2, R3, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein, in combination with other drug therapies to treat adverse weight gain.
Type:
Application
Filed:
February 8, 2006
Publication date:
May 21, 2009
Applicant:
XENON PHARMACEUTICALS INC.
Inventors:
Rajender Kamboj, Michael D. Winther, Robert Fraser, Mikhail Chafeev, Sultan Chowdhury, Jian-Min Fu, Duanjie Hou, Shifeng Liu, Vandna Raina, Mehran Seid Bagherzadeh, Serguei Sviridov, Kashinath Sadalapure, Shaoyi Sun, Vishnumurthy Kodumuru, Nagasree Chakka, Zaihui Zhang, Melwyn Abreo, Mikhail A. Kondratenko, Daniel F. Harvey, Cindy J. Hudson, Wenbao Li, Chi Tu, Sengen Sun, Mark W. Holladay, Heinz W. Gschwend
Patent number: 7335658
Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where x, y, W, V, R2, R3, R4, R5, R6, R6a, R7, R7a, R8, R8a, R9 and R9a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
Type:
Grant
Filed:
July 29, 2004
Date of Patent:
February 26, 2008
Assignee:
Xenon Pharmaceuticals Inc.
Inventors:
Nagasree Chakka, Mikhail Chafeev, Sultan Chowdhury, Jian-Min Fu, Duanjie Hou, Rajender Kamboj, Vishnumurthy Kodumuru, Shifeng Liu, Vandna Raina, Shaoyi Sun, Serguei Sviridov, Michael D Winther, Zaihui Zhang, Melwyn Abreo, Mark W Holladay, Wenbao Li, Sengen Sun, Chi Tu, Heinz W Gschwend
Publication number: 20060252812
Abstract: This invention is directed to spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.
Type:
Application
Filed:
April 11, 2006
Publication date:
November 9, 2006
Applicant:
Xenon Pharmaceuticals Inc.
Inventors:
Mikhail Chafeev, Nagasree Chakka, Sultan Chowdhury, Robert Fraser, Jianmin Fu, Duanjie Hou, Tom Hsieh, Rajender Kamboj, Shifeng Liu, Vandna Raina, Mehran Bagherzadeh, Jianyu Sun, Shaoyi Sun, Serguei Sviridov
Publication number: 20060009459
Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (Ia): where x, y, W, V, R2, R3, R4, R5, R6, R6a, R7, R7a, R8, R8a, R9 and R9a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
Type:
Application
Filed:
February 9, 2005
Publication date:
January 12, 2006
Inventors:
Nagasree Chakka, Mikhail Chafeev, Sultan Chowdhury, Jian-Min Fu, Duanjie Hou, Rajender Kamboj, Vishnumurthy Kodumuru, Shifeng Liu, Vandna Raina, Shaoyi Sun, Serguei Sviridov, Michael Winther, Zaihui Zhang, Melwyn Abreo, Mark Holladay, Wenbao Li, Sengen Sun, Chi Tu, Heinz Gschwend
Publication number: 20050065143
Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where x, y, W, V, R2, R3, R4, R5, R6, R6a, R7, R7a, R8, R8a, R9 and R9a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
Type:
Application
Filed:
July 29, 2004
Publication date:
March 24, 2005
Applicant:
Xenon Pharmaceuticals Inc.
Inventors:
Nagasree Chakka, Mikhail Chafeev, Sultan Chowdhury, Jian-Min Fu, Duanjie Hou, Rajender Kamboj, Vishnumurthy Kodumuru, Shifeng Liu, Vandna Raina, Shaoyi Sun, Serguei Sviridov, Michael Winther, Zaihui Zhang, Melwyn Abreo, Mark Holladay, Wenbao Li, Sengen Sun, Chi Tu, Heinz Gschwend