Patents by Inventor Mikhail Gusyatiner

Mikhail Gusyatiner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20060088919
    Abstract: There is disclosed a method for producing L-amino acid, for example L-threonine, L-lysine, L-histidine, L-phenylalanine, L-arginine or L-glutamic acid, using a bacterium of the Enterobacteriaceae family, wherein the bacterium has been modified to enhance an activity of D-xylose permease.
    Type: Application
    Filed: October 12, 2005
    Publication date: April 27, 2006
    Inventors: Konstantin Rybak, Ekaterina Slivinskaya, Ekaterina Savrasova, Valeriy Akhverdian, Elena Klyachko, Sergei Mashko, Vera Doroshenko, Larisa Airikh, Tatyana Leonova, Mikhail Gusyatiner, Elvira Voroshilova, Yury Kozlov, Yoshihiko Hara, Takuji Ueda
  • Publication number: 20060035343
    Abstract: L-arginine, citrulline and pyrimidine derivatives including orotic acid, uridine, uridine 5?-monophosphate (UMP), cytidine and cytidine. 5?-monophosphate (CMP) are produced using a bacterium belonging to the genus Escherichia harboring a mutant carbamoylphosphate synthetase in which the amino acid sequence corresponding to positions from 947 to 951 in a wild type carbamoylphosphate synthetase is replaced with any one of amino acid sequences of SEQ ID NOS: 1 to 9, and feedback inhibition by uridine 5?-monophosphate in the bacterium is desensitized.
    Type: Application
    Filed: October 20, 2005
    Publication date: February 16, 2006
    Applicant: AJINOMOTO CO., INC
    Inventors: Leonid Ptitsyn, Sergey Smirnov, Irina Altman, Anna Novikova, Veronika Kotliarova, Mikhail Gusyatiner, Yulia Rostova, Tatyana Yampolskaya
  • Publication number: 20050255567
    Abstract: Amino acids, such as L-glutamine, L-arginine, L-tryptophan, L-histidine and L-glutamate are produced using a bacterium belonging to the genus Escherichia harboring a mutant glutamine synthetase in which the tyrosine amino acid residue corresponding to position 397 in a wild type glutamine synthetase is replaced with any of amino acid residues, preferably with phenylalanine.
    Type: Application
    Filed: June 28, 2005
    Publication date: November 17, 2005
    Applicant: Ajinomoto Co., Inc.
    Inventors: Mikhail Gusyatiner, Lirina Ivanovskaya, Tatyana Leonova, Ekaterina Mukhanova, Yulia Rostova, Dmitriy Filippov, Daria Chudakova
  • Publication number: 20050239175
    Abstract: There is provided a method for producing L-threonine, L-valine, L-proline, L-leucine, L-methionine and L-arginine using bacterium belonging to the genus Escherichia wherein L-amino acid productivity of the bacterium is enhanced by enhancing an activity of proteins coded by b2682 and b2683 genes, or protein coded by b1242 or b3434 gene.
    Type: Application
    Filed: February 13, 2002
    Publication date: October 27, 2005
    Applicant: AJINOMOTO CO., INC.
    Inventors: Ekaterina Tabolina, Konstantin Rybak, Evgeni Khourges, Elvira Voroshilova, Mikhail Gusyatiner
  • Publication number: 20050214911
    Abstract: A method for producing an L-amino acid, such as L-histidine, L-threonine, L-lysine, L-glutamic acid, and L-tryptophan, using bacterium belonging to the genus Escherichia which has increased expression of genes, such as those of the xylABFGHR locus, which encode the xylose utilization enzymes, is disclosed. The method includes cultivating the L-amino acid producing bacterium in a culture medium containing xylose, and collecting the L-amino acid from the culture medium.
    Type: Application
    Filed: March 15, 2005
    Publication date: September 29, 2005
    Inventors: Aleksey Marchenko, Sergey Benevolensky, Elena Klyachko, Yuri Kozlov, Elvira Voroshilova, Mikhail Gusyatiner
  • Publication number: 20050124049
    Abstract: A method is provided for producing L-cysteine using a bacterium belonging to the genus Escherichia, wherein the L-amino acid productivity of said bacterium is enhanced by increasing expression of the cysPTWAM cluster genes.
    Type: Application
    Filed: October 25, 2004
    Publication date: June 9, 2005
    Inventors: Mikhail Ziyatdinov, Ekaterina Redkina, Mikhail Gusyatiner
  • Publication number: 20050112731
    Abstract: O-acetylserine, L-cysteine and sulphurous compounds derived therefrom may be produced using a bacterium belonging to the genus Escherichia which harbors a mutant feedback-resistant serine acetyltransferases in which the amino acid sequence corresponding to positions from 89 to 96 in a wild-type serine acetyltransferase is replaced with any one of the amino acid sequences shown in SEQ ID NOS: 4 to 9, and feedback inhibition by L-cysteine in the bacterium is desensitized.
    Type: Application
    Filed: July 16, 2004
    Publication date: May 26, 2005
    Inventors: Tatsuki Kashiwagi, Yuko Kai, Kohki Ishikawa, Ei-ichiro Suzuki, Hiroshi Takagi, Mikhail Ziyatdinov, Ekaterina Redkina, Mikhail Gusyatiner
  • Publication number: 20050026259
    Abstract: Arginine can be efficiently produced by cultivating Escherichia coli which has an ability to produce arginine and an ability to utilize acetate in a culture medium to produce and accumulate arginine in the medium, and collecting arginine from the medium.
    Type: Application
    Filed: August 25, 2004
    Publication date: February 3, 2005
    Applicant: Ajinomoto Co., Inc.
    Inventors: Mikhail Gusyatiner, Tatyana Leonova, Leonid Ptitsyn, Tatyana Yampolskaya
  • Publication number: 20050026258
    Abstract: L-arginine is produced using a bacterium belonging to the genus Escherichia harboring a mutant N-acetylglutamate synthase in which the amino acid sequence corresponding to positions from 15 to 19 in a wild type N-acetylglutamate synthase is replaced with any one of amino acid sequences of SEQ ID NOS: 1 to 4, and feedback inhibition by L-arginine is desensitized.
    Type: Application
    Filed: July 15, 2004
    Publication date: February 3, 2005
    Applicant: Ajinomoto Co., Inc.
    Inventors: Leonid Ptitsyn, Irina Altman, Sergey Smirnov, Yulia Rostova, Tatyana Yampolskaya, Tatyana Leonova, Mikhail Gusyatiner