Abstract: Method for suppressing bone cancer-induced allodynia in a patient, the method comprising administration of a therapeutically effective amount of a non-cytotoxic protease to a patient suffering from bone cancer.

Abstract: The present invention provides a clostridial neurotoxin for use in a method of treating a brain disorder in a patient by promoting a neuroimmune response.

Abstract: The present invention relates to a clostridial neurotoxin for use in treating post-operative surgical pain in a patient, said method comprising administering to a patient a clostridial neurotoxin more than 5 days prior to surgery and wherein the clostridial neurotoxin is administered: i) intradermally; or ii) intrathecally. Also provided are corresponding methods of treatment and administration dosages of a clostridial neurotoxin.

Abstract: Method of treating or reducing a symptom of traumatic brain injury (TBI) in a subject, comprising administering to the subject a therapeutically-effective amount of botulinum neurotoxin. Composition for use in treating or reducing a symptom of TBI in a subject comprising botulinum neurotoxin. Computer system programmed to receive information related to a subject's response to administration of botulinum neurotoxin, store that response in a database, and transmit the response to a medical practitioner. Non-transitory computer-readable storage medium storing instructions that, when executed by a computer system, causes the computer system to perform the aforementioned steps.

Abstract: The present invention provides a method for suppressing bone cancer-induced allodynia in a patient, said method comprising administration of a therapeutically effective amount of a non-cytotoxic protease to a patient suffering from bone cancer.