Patents by Inventor Mikhail Kolot

Mikhail Kolot has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SITE SPECIFIC RECOMBINASE INTEGRASE VARIANTS AND USES THEREOF IN GENE EDITING IN EUKARYOTIC CELLS
    Publication number: 20220154221
    Abstract: The invention relates to novel variants and mutants of HK022 bacteriophage integrase (HK-Int), systems, kits, compositions, methods and uses thereof for gene therapy using site-specific recombination. More specifically, the invention further provides donor cassettes comprising replacement sequences for targeted replacement of target nucleic acid sequences using the HK-Int variants of the invention.
    Type: Application
    Filed: February 11, 2020
    Publication date: May 19, 2022
    Inventors: Mikhail KOLOT, Amer ELIAS
  • Use of integrase for targeted gene expression
    Patent number: 9816077
    Abstract: There are provided methods and compositions for activating the expression of an exogenous gene by an exogenous integrase specifically in cells in which the exogenous integrase is expressed. The invention further relates to uses of the compositions in treatment of various conditions and disorders, as exemplified by selectively activating expression of a toxin only in target cell populations.
    Type: Grant
    Filed: August 1, 2012
    Date of Patent: November 14, 2017
    Assignee: RAMOT AT TEL-AVIV UNIVERSITY LTD.
    Inventors: Mikhail Kolot, Ezra Yagil, Natalia Malchin
  • USE OF INTEGRASE FOR TARGETED GENE EXPRESSION
    Publication number: 20140171494
    Abstract: There are provided methods and compositions for activating the expression of an exogenous gene by an exogenous integrase specifically in cells in which the exogenous integrase is expressed. The invention further relates to uses of the compositions in treatment of various conditions and disorders, as exemplified by selectively activating expression of a toxin only in target cell populations.
    Type: Application
    Filed: August 1, 2012
    Publication date: June 19, 2014
    Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.
    Inventors: Mikhail Kolot, Ezra Yagil, Natalia Malchin