Patents by Inventor Mikhail Kostylev

Mikhail Kostylev has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240393345
    Abstract: In one aspect, the invention provides a protein capture membrane comprising a first side and a second side and a plurality of interstices extending contiguously from the first side to the second side, wherein the interstices are coated with a protein-reactive coating; and the porous substrate comprises nanoporous alumina or porous glass. In another aspect the invention provides a method of detecting a protein of interest in a plurality of proteins.
    Type: Application
    Filed: July 31, 2024
    Publication date: November 28, 2024
    Inventors: Erik Gunther, Mikhail Kostylev, Stephen Strittmatter
  • Patent number: 12085572
    Abstract: In one aspect, the invention provides a protein capture membrane comprising a first side and a second side and a plurality of interstices extending contiguously from the first side to the second side, wherein the interstices are coated with a protein-reactive coating; and the porous substrate comprises nanoporous alumina or porous glass. In another aspect the invention provides a method of detecting a protein of interest in a plurality of proteins.
    Type: Grant
    Filed: May 7, 2019
    Date of Patent: September 10, 2024
    Assignee: Yale University
    Inventors: Erik Gunther, Mikhail Kostylev, Stephen Strittmatter
  • Publication number: 20220370976
    Abstract: The present disclosure provides methods of transferring bio-molecular components of individual cells in a biological sample to a solid porous substate. The method including contacting the biological sample to a first side of the porous solid substrate having a plurality of interstices or pores extending contiguously from the first side to a second side, transferring and affixing the bio-molecular components of the biological sample to the interstices or pores of the solid substrate. The present disclosure further provides methods of examining or detecting one or more bio-molecular components of individual cells in a biological sample. The method includes transferring one or more bio-molecular components of individual cells in a biological sample to a solid porous substate, and detecting one or more of the bio-molecular components of the biological sample.
    Type: Application
    Filed: April 29, 2022
    Publication date: November 24, 2022
    Inventors: Mikhail Kostylev, Erik Gunther
  • Publication number: 20220281913
    Abstract: The present invention provides a protein separation micro el having a first plate having a first opening; a second plate; a gel substrate formed between the first plate and the second plate; and a plurality of wells positioned at a first non-zero distance from a first edge of the gel and at a second non-zero distance from a second edge of the gel; wherein the first and second edge of the gel are opposite edges of the gel.
    Type: Application
    Filed: August 12, 2020
    Publication date: September 8, 2022
    Inventors: Erik Gunther, Mikhail Kostylev, Stephen Strittmatter
  • Publication number: 20210132077
    Abstract: In one aspect, the invention provides a protein capture membrane comprising a first side and a second side and a plurality of interstices extending contiguously from the first side to the second side, wherein the interstices are coated with a protein-reactive coating; and the porous substrate comprises nanoporous alumina or porous glass. In another aspect the invention provides a method of detecting a protein of interest in a plurality of proteins.
    Type: Application
    Filed: May 7, 2019
    Publication date: May 6, 2021
    Inventors: Erik Gunther, Mikhail Kostylev, Stephen Strittmatter