Patents by Inventor Mikhail S. DZYURKEVICH

Mikhail S. DZYURKEVICH has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyridoxine derivative for treatment of epilepsy
    Patent number: 10844018
    Abstract: A pyridoxine-based compound of formula 1: exhibits a high level of antiepileptic activity. At doses of 25, 50 and 100 mg/kg, compound 1 completely suppresses the epileptic electrical activity of the brain within an hour after intraperitoneal administration to rats on the penicillin model of epilepsy. The rats' corazol model of epilepsy shows a decrease in intensity and duration of seizures with the administration of compound 1 at doses of 25 and 100 mg/kg intraperitoneally and 100 and 200 mg/kg orally, and the complete prevention of seizures in some cases at a dosage of 250 mg/kg with oral administration. Compound 1 is low toxic. The LD50 parameter in rats exceeds 2000 and 5000 mg/kg of body weight with intraperitoneal and oral administration respectively. The technical solution provides a new highly effective and safe drug for the treatment of epilepsy.
    Type: Grant
    Filed: January 24, 2020
    Date of Patent: November 24, 2020
    Assignees: AO “Tatkhimfarmpreparaty”, Kazan Federal University
    Inventors: Yurij G. Shtyrlin, Mikhail S. Dzyurkevich, Nikita V. Shtyrlin, Elena V. Gerasimova, Al'fiya G. Iksanova, Guzel′ F. Sitdikova, Aleksej V. Yakovlev
  • Antibacterial agents based on ciprofloxacin derivatives
    Patent number: 10759810
    Abstract: New derivatives of ciprofloxacin of the general formula (I) show antibacterial properties. The compounds can be used in medicine and veterinary.
    Type: Grant
    Filed: April 29, 2019
    Date of Patent: September 1, 2020
    Assignees: AO “Tatkhimfarmpreparaty”, Kazan Federal University
    Inventors: Yurij G. Shtyrlin, Nikita V. Shtyrlin, Mikhail V. Pugachev, Roman S. Pavel'Ev, Al'fiya G. Iksanova, Elena V. Nikitina, Mikhail S. Dzyurkevich
  • Pyridoxine Derivative for Treatment of Epilepsy
    Publication number: 20200157051
    Abstract: A pyridoxine-based compound of formula 1: exhibits a high level of antiepileptic activity. At doses of 25, 50 and 100 mg/kg, compound 1 completely suppresses the epileptic electrical activity of the brain within an hour after intraperitoneal administration to rats on the penicillin model of epilepsy. The rats' corazol model of epilepsy shows a decrease in intensity and duration of seizures with the administration of compound 1 at doses of 25 and 100 mg/kg intraperitoneally and 100 and 200 mg/kg orally, and the complete prevention of seizures in some cases at a dosage of 250 mg/kg with oral administration. Compound 1 is low toxic. The LD50 parameter in rats exceeds 2000 and 5000 mg/kg of body weight with intraperitoneal and oral administration respectively. The technical solution provides a new highly effective and safe drug for the treatment of epilepsy.
    Type: Application
    Filed: January 24, 2020
    Publication date: May 21, 2020
    Inventors: Yurij G. SHTYRLIN, Mikhail S. DZYURKEVICH, Nikita V. SHTYRLIN, Elena V. GERASIMOVA, Al'fiya G. IKSANOVA, Guzel' F. SITDIKOVA, Aleksej V. YAKOVLEV
  • Antibacterial Agents Based on Ciprofloxacin Derivatives
    Publication number: 20190248802
    Abstract: New derivatives of ciprofloxacin of the general formula (I) show antibacterial properties. The compounds can be used in medicine and veterinary.
    Type: Application
    Filed: April 29, 2019
    Publication date: August 15, 2019
    Inventors: Yurij G. SHTYRLIN, Nikita V. SHTYRLIN, Mikhail V. PUGACHEV, Roman S. PAVEL'EV, Al'fiya G. IKSANOVA, Elena V. NIKITINA, Mikhail S. DZYURKEVICH