Abstract: Disclosed are various embodiments of invasive and non-invasive systems for electrophysiological mapping of a patient's heart, where cardiac action potentials (APs) on a myocardial surface of a human heart are reconstructed. In one embodiment, the APs are reconstructed using known electrical potentials on the myocardial surface in combination with known geometries of the heart and/or the torso. A mathematical model of cardiac electrical activity may be employed that takes into account homogeneous and isotropic intracellular, extracellular, and human body electrical conductivities.

Abstract: Disclosed are various embodiments of invasive and non-invasive systems for electrophysiological mapping of a patient's heart, where cardiac action potentials (APs) on a myocardial surface of a human heart are reconstructed. In one embodiment, the APs are reconstructed using known electrical potentials on the myocardial surface in combination with known geometries of the heart and/or the torso. A mathematical model of cardiac electrical activity may be employed that takes into account homogeneous and isotropic intracellular, extracellular, and human body electrical conductivities.

Abstract: Disclosed are various embodiments of invasive and non-invasive systems for combined electrophysiological mapping and ablation of a patient's heart. An electrophysiological mapping system (EMS) is configured to operate in conjunction with a cardiac ablation system, which in an invasive embodiment may employ an ablation catheter configured for insertion inside the heart of the patient, and in a non-invasive embodiment may comprise a HIFU transducer. The EMS is programmed and configured to process ECG signals acquired from a patient's torso during the combined electrophysiological mapping and cardiac ablation procedure, and to produce on a display or monitor the real-time or near-real-time voxel-model-derived visual representation of one or more locations on the patient's heart where at least one scar has been created by the ablation device during the combined procedure.