Patents by Inventor Mikhail Zibinsky

Mikhail Zibinsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immunoregulatory agents
    Patent number: 11932601
    Abstract: Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.
    Type: Grant
    Filed: December 16, 2021
    Date of Patent: March 19, 2024
    Assignee: Flexus Biosciences, Inc.
    Inventors: Hilary Plake Beck, Juan Carlos Jaen, Maksim Osipov, Jay Patrick Powers, Maureen Kay Reilly, Hunter Paul Shunatona, James Ross Walker, Mikhail Zibinsky, James Aaron Balog, David K. Williams, Weiwei Guo
  • Substituted quinolinylcyclohexylpropanamide compounds and improved methods for their preparation
    Patent number: 11919863
    Abstract: The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds.
    Type: Grant
    Filed: December 16, 2021
    Date of Patent: March 5, 2024
    Assignee: Bristol-Myers Squibb Company
    Inventors: Albert J. Delmonte, Benjamin M. Cohen, Kenneth Joseph Fraunhoffer, Sergei Kolotuchin, Francisco Gonzalez-Bobes, Gregory Louis Beutner, Adam Joseph Freitag, Michael Scott Bultman, Yu Fan, Prantik Maity, Ian Scott Young, Hilary Plake Beck, Maksim Osipov, Jay Patrick Powers, Maureen Kay Reilly, Hunter Paul Shunatona, James Ross Walker, Mikhail Zibinsky
  • Pyrazole pyrimidine compounds and uses thereof
    Patent number: 11918582
    Abstract: Disclosed herein are pyrazole pyrimidine compounds that modulate and/or inhibit hematopoietic progenitor kinase 1, as well as methods of making such compounds and therapeutic methods of using same.
    Type: Grant
    Filed: March 14, 2022
    Date of Patent: March 5, 2024
    Assignee: RAPT Therapeutics, Inc.
    Inventors: Cyril Bucher, Adrian Dukes, Blanca Gomez, Hannah Haley, Dennis Hu, Jeffrey J. Jackson, Michelle Yoo Min Ko, Paul Leger, Anqi Ma, Andrew A. Ng, Daniel Poon, Omar Robles, Anton Shakhmin, Grant Shibuya, Parcharee Tivitmahaisoon, Vi-Anh Vu, David J. Wustrow, Mikhail Zibinsky
  • CHEMOKINE RECEPTOR MODULATORS AND USES THEREOF
    Publication number: 20230322741
    Abstract: Disclosed herein, inter alia, are compounds and methods of use thereof for the modulation of certain chemokine receptor activity.
    Type: Application
    Filed: April 5, 2023
    Publication date: October 12, 2023
    Inventors: Parcharee Tivitmahaisoon, David J. Wustrow, Mikhail Zibinsky, Omar Robles
  • CHEMOKINE RECEPTOR MODULATORS AND USES THEREOF
    Publication number: 20230139321
    Abstract: Disclosed herein, inter alia, are compounds and methods of use thereof for the modulation of certain chemokine receptor activity.
    Type: Application
    Filed: May 20, 2022
    Publication date: May 4, 2023
    Inventors: Jeffrey J. Jackson, John Michael Ketcham, Akinori Okano, Maureen Kay Reilly, Omar Robles-Resendiz, Jacob Bradley Schwarz, Parcharee Tivitmahaisoon, David Juergen Wustrow, Ashkaan Younai, Mikhail Zibinsky
  • PYRAZOLE PYRIMIDINE COMPOUNDS AND USES THEREOF
    Publication number: 20220305018
    Abstract: Disclosed herein are pyrazole pyrimidine compounds that modulate and/or inhibit hematopoietic progenitor kinase 1, as well as methods of making such compounds and therapeutic methods of using same.
    Type: Application
    Filed: March 14, 2022
    Publication date: September 29, 2022
    Inventors: Cyril Bucher, Adrian Dukes, Blanca Gomez, Hannah Haley, Dennis Hu, Jeffrey J. Jackson, Michelle Yoo Min Ko, Paul Leger, Anqi Ma, Andrew A. Ng, Daniel Poon, Omar Robles, Anton Shakhmin, Grant Shibuya, Parcharee Tivitmahaisoon, Vi-Anh Vu, David J. Wustrow, Mikhail Zibinsky
  • IMMUNOREGULATORY AGENTS
    Publication number: 20220274926
    Abstract: Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.
    Type: Application
    Filed: December 16, 2021
    Publication date: September 1, 2022
    Inventors: Hilary Plake BECK, Juan Carlos JAEN, Maksim OSIPOV, Jay Patrick POWERS, Maureen Kay REILLY, Hunter Paul SHUNATONA, James Ross WALKER, Mikhail ZIBINSKY, James Aaron BALOG, David K. WILLIAMS, Weiwei GUO
  • SUBSTITUTED QUINOLINYLCYCLOHEXYLPROPANAMIDE COMPOUNDS AND IMPROVED METHODS FOR THEIR PREPARATION
    Publication number: 20220267273
    Abstract: The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds.
    Type: Application
    Filed: December 16, 2021
    Publication date: August 25, 2022
    Inventors: Albert J. DELMONTE, Benjamin M. COHEN, Kenneth Joseph FRAUNHOFFER, Sergei KOLOTUCHIN, Francisco GONZALEZ-BOBES, Gregory Louis BEUTNER, Adam Joseph FREITAG, Michael Scott BULTMAN, Yu FAN, Prantik MAITY, Ian Scott YOUNG, Hilary Plake BECK, Maksim OSIPOV, Jay Patrick POWERS, Maureen Kay REILLY, Hunter Paul SHUNATONA, James Ross WALKER, Mikhail ZIBINSKY
  • METHODS OF MAKING TRANS ISOMERIC FORMS OF G PROTEIN-COUPLED RECEPTOR MODULATORS
    Publication number: 20220251070
    Abstract: Disclosed herein, inter alia, methods of synthesis of trans isomeric forms of G protein-coupled receptor modulators of high trans isomeric purity.
    Type: Application
    Filed: January 28, 2022
    Publication date: August 11, 2022
    Inventors: Cyril Bucher, James P. Davidson, Jeffrey J. Jackson, Michelle Yoo Min Ko, Grant Shibuya, David J. Wustrow, Ashkaan Younai, Mikhail Zibinsky
  • Chemokine receptor modulators and uses thereof
    Patent number: 11384064
    Abstract: Disclosed herein, inter alia, are compounds and methods of use thereof for the modulation of certain chemokine receptor activity.
    Type: Grant
    Filed: April 27, 2020
    Date of Patent: July 12, 2022
    Assignee: RAPT Therapeutics, Inc.
    Inventors: Jeffrey J. Jackson, John Michael Ketcham, Akinori Okano, Maureen Kay Reilly, Omar Robles-Resendiz, Jacob Bradley Schwarz, Parcharee Tivitmahaisoon, David Juergen Wustrow, Ashkaan Younai, Mikhail Zibinsky
  • AMORPHOUS AND CRYSTALLINE FORMS OF IDO INHIBITORS
    Publication number: 20220169615
    Abstract: The present disclosure relates to amorphous and crystalline forms of (R)-N-(4-chlorophenyl)-2-(1S,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamide and its salts and hydrates, processes for their production, pharmaceutical compositions comprising them, and methods of treatment using them.
    Type: Application
    Filed: December 16, 2021
    Publication date: June 2, 2022
    Inventors: Jay Patrick POWERS, Hilary Plake BECK, Maksim OSIPOV, Maureen Kay REILLY, Hunter Paul SHUNATONA, James Ross WALKER, Mikhail ZIBINSKY, Tamar ROSENBAUM, Ian Scott YOUNG, Jennifer NELSON, Petinka VLAHOVA
  • SUBSTITUTED QUINOLINYLCYCLOHEXYLPROPANAMIDE COMPOUNDS AND IMPROVED METHODS FOR THEIR PREPARATION
    Publication number: 20220127233
    Abstract: The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds.
    Type: Application
    Filed: November 12, 2021
    Publication date: April 28, 2022
    Inventors: Albert J. DELMONTE, Benjamin M. COHEN, Kenneth Joseph FRAUNHOFFER, Sergei KOLOTUCHIN, Francisco GONZALEZ-BOBES, Gregory Louis BEUTNER, Adam Joseph FREITAG, Michael Scott BULTMAN, Yu FAN, Prantik MAITY, Ian Scott YOUNG, Hilary Plake BECK, Maksim OSIPOV, Jay Patrick POWERS, Maureen Kay REILLY, Hunter Paul SHUNATONA, James Ross WALKER, Mikhail ZIBINSKY
  • Immunoregulatory agents
    Patent number: 11242319
    Abstract: Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.
    Type: Grant
    Filed: November 5, 2015
    Date of Patent: February 8, 2022
    Assignee: Flexus Biosciences, Inc.
    Inventors: Hilary Plake Beck, Juan Carlos Jaen, Maksim Osipov, Jay Patrick Powers, Maureen Kay Reilly, Hunter Paul Shunatona, James Ross Walker, Mikhail Zibinsky, James Aaron Balog, David K. Williams, Weiwei Guo
  • Substituted quinolinylcyclohexylpropanamide compounds and improved methods for their preparation
    Patent number: 11236048
    Abstract: The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: February 1, 2022
    Assignee: Bristol-Myers Squibb Company
    Inventors: Albert J. Delmonte, Benjamin M. Cohen, Kenneth Joseph Fraunhoffer, Sergei Kolotuchin, Francisco Gonzalez-Bobes, Gregory Louis Beutner, Adam Joseph Freitag, Michael Scott Bultman, Yu Fan, Prantik Maity, Ian Scott Young, Hilary Plake Beck, Maksim Osipov, Jay Patrick Powers, Maureen Kay Reilly, Hunter Paul Shunatona, James Ross Walker, Mikhail Zibinsky
  • Amorphous and crystalline forms of IDO inhibitors
    Patent number: 11236049
    Abstract: The present disclosure relates to amorphous and crystalline forms of (R)-N-(4-chlorophenyl)-2-((1S,4S)-4-(6-fluoro-quinolin-4-yl) cyclohexyl)propanamide and its salts and hydrates, processes for their production, pharmaceutical compositions comprising them, and methods of treatment using them.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: February 1, 2022
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jay Patrick Powers, Hilary Plake Beck, Maksim Osipov, Maureen Kay Reilly, Hunter Paul Shunatona, James Ross Walker, Mikhail Zibinsky, Tamar Rosenbaum, Ian Scott Young, Jennifer Nelson, Petinka Vlahova
  • Chemokine receptor modulators and uses thereof
    Patent number: 11192879
    Abstract: Disclosed herein, inter alia, are compounds and methods of use thereof for the modulation of certain chemokine receptor activity.
    Type: Grant
    Filed: April 27, 2020
    Date of Patent: December 7, 2021
    Assignee: RAPT THERAPEUTICS, INC.
    Inventors: Jeffrey J. Jackson, John Michael Ketcham, Akinori Okano, Maureen Kay Reilly, Omar Robles-Resendiz, Jacob Bradley Schwarz, Parcharee Tivitmahaisoon, David Juergen Wustrow, Ashkaan Younai, Mikhail Zibinsky
  • Pyrazolo-pyrimidin-amino-cycloalkyl compounds and their therapeutic uses
    Patent number: 11046699
    Abstract: Disclosed herein are pyrozolo-pyrimidin-amino-cycloalkyl compounds, analogs thereof, pharmaceutical compositions comprising thereof and therapeutic uses therefor.
    Type: Grant
    Filed: June 4, 2019
    Date of Patent: June 29, 2021
    Assignee: RAPT THERAPEUTICS, INC.
    Inventors: Minna H. T. Bui, Adrian O. Dukes, Xinping Han, Dennis X. Hu, Jeffrey J. Jackson, Yoo Min Ko, Paul R. Leger, Anqi Ma, Jack Maung, Andrew A. Ng, Akinori Okano, Omar Robles, Grant Shibuya, Hunter P. Shunatona, Jacob B. Schwarz, Anton A. Shakhmin, David J. Wustrow, Mikhail Zibinsky
  • CRYSTALLINE FORMS OF C-C CHEMOKINE RECEPTOR TYPE 4 ANTAGONIST AND USES THEREOF
    Publication number: 20210139487
    Abstract: Crystalline forms of a C-C chemokine receptor type 4 (CCR4) antagonist, oral dosage forms of same and methods of using and preparing same, are provided.
    Type: Application
    Filed: November 13, 2020
    Publication date: May 13, 2021
    Inventors: David J. ARNOLD, Omar ROBLES, Duane E. RUDISILL, David J. WUSTROW, Mikhail ZIBINSKY, Sami KARABORNI
  • Immunoregulatory agents
    Patent number: 10987322
    Abstract: Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.
    Type: Grant
    Filed: June 5, 2015
    Date of Patent: April 27, 2021
    Assignee: Flexus Biosciences, Inc.
    Inventors: Juan Carlos Jaen, Maksim Osipov, Jay Patrick Powers, Hunter Paul Shunatona, James Ross Walker, Mikhail Zibinsky
  • CHEMOKINE RECEPTOR MODULATORS AND USES THEREOF
    Publication number: 20200339539
    Abstract: Disclosed herein, inter alia, are compounds and methods of use thereof for the modulation of certain chemokine receptor activity.
    Type: Application
    Filed: April 27, 2020
    Publication date: October 29, 2020
    Inventors: Jeffrey J. Jackson, John Michael Ketcham, Akinori Okano, Maureen Kay Reilly, Omar Robles-Resendiz, Jacob Bradley Schwarz, Parcharee Tivitmahaisoon, David Juergen Wustrow, Ashkaan Younai, Mikhail Zibinsky