Abstract: An object of the present invention is to provide methods of discovering drugs effective for tough targets, which have conventionally been discovered only with difficulty. The present invention relates to novel methods for cyclizing peptide compounds, and novel peptide compounds and libraries comprising the same, to achieve the above object.

Abstract: A filler that can suppress thermal expansion of a glass composition with a small amount thereof added and is also excellent in terms of flowability when the glass composition is melted, and a glass composition containing the filler are provided. There is also provided a process for producing a hexagonal phosphate-based compound that can be suitably used as the filler using a simple, industrially advantageous method. The filler of the present invention contains a hexagonal phosphate-based compound that has a purity of 90% or higher and is represented by the following Formula 1, the filler having a content of an ionic compound that is no greater than 1.0 wt %, KaZrb(PO4)3??(1) wherein, in Formula 1, a is a positive number of from 0.8 to 1.2 and b is a positive number satisfying a+4b=9.

Abstract: A filler that can suppress thermal expansion of a glass composition with a small amount thereof added and is also excellent in terms of flowability when the glass composition is melted, and a glass composition containing the filler are provided. There is also provided a process for producing a hexagonal phosphate-based compound that can be suitably used as the filler using a simple, industrially advantageous method. The filler of the present invention contains a hexagonal phosphate-based compound that has a purity of 90% or higher and is represented by the following Formula 1, the filler having a content of an ionic compound that is no greater than 1.0 wt %, KaZrb(PO4)3 ??(1) wherein, in Formula 1, a is a positive number of from 0.8 to 1.2 and b is a positive number satisfying a+4b=9.