Patents by Inventor Miki Shitashige

Miki Shitashige has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bicyclic thiazole compounds
    Patent number: 9102637
    Abstract: The present invention relates to novel bicyclic thiazole compounds that inhibit Traf2- and Nck-interacting kinase (TNIK), and as such are useful as TNIK inhibitors administered to cancer patients, especially to solid cancer patients such as colorectal cancer, pancreatic cancer, non-small cell lung cancer, prostate cancer or breast cancer. The bicyclic thiazole compounds are showed by a next formula (I). (wherein R1, R2, R3 and Q are as defined in the specification), or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: May 22, 2013
    Date of Patent: August 11, 2015
    Assignees: CARNA BIOSCIENCES, INC., NATIONAL CANCER CENTER
    Inventors: Masaaki Sawa, Hideki Moriyama, Tesshi Yamada, Miki Shitashige, Yusuke Kawase, Yuko Uno
  • NOVEL BICYCLIC THIAZOLE COMPOUNDS
    Publication number: 20150133656
    Abstract: The present invention relates to novel bicyclic thiazole compounds that inhibit Traf2- and Nck-interacting kinase (TNIK), and as such are useful as TNIK inhibitors administered to cancer patients, especially to solid cancer patients such as colorectal cancer, pancreatic cancer, non-small cell lung cancer, prostate cancer or breast cancer. The bicyclic thiazole compounds are showed by a next formula (I). (wherein R1, R2, R3 and Q are as defined in the specification), or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: May 22, 2013
    Publication date: May 14, 2015
    Applicants: CARNA BIOSCIENCES INC., NATIONAL CANCER CENTER
    Inventors: Masaaki Sawa, Hideki Moriyama, Tesshi Yamada, Miki Shitashige, Yusuke Kawase, Yuko Uno
  • NOVEL BICYCLIC THIAZOLE COMPOUNDS
    Publication number: 20130317218
    Abstract: The present invention relates to novel bicyclic thiazole compounds that inhibit Traf2- and Nck-interacting kinase (TNIK), and as such are useful as TNIK inhibitors administered to cancer patients, especially to solid cancer patients such as colorectal cancer, pancreatic cancer, non-small cell lung cancer, prostate cancer or breast cancer. The bicyclic thiazole compounds are showed by a next formula (I). (wherein R1, R2, R3 and Q are as defined in the specification), or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: May 24, 2012
    Publication date: November 28, 2013
    Inventors: Masaaki Sawa, Hideki Moriyama, Tesshi Yamada, Miki Shitashige, Yusuke Kawase, Yuko Uno
  • Screening method for anticancer drug
    Patent number: 8323943
    Abstract: The screening method for an anticancer drug comprises selecting a compound which blocks the kinase activity of TNIK, or blocks the combination of TNIK with ?-catenin/TC4 transcription complex.
    Type: Grant
    Filed: August 13, 2008
    Date of Patent: December 4, 2012
    Assignee: National Cancer Center
    Inventors: Tesshi Yamada, Miki Shitashige, Setsuo Hirohashi
  • TNIK INHIBITOR AND THE USE
    Publication number: 20100216795
    Abstract: The present invention relates to Traf2- and Nck-interacting kinase (TNIK) inhibitors, pharmaceutical compositions, and methods for the treatment of cancer patients with TNIK inhibitors. And the present invention relates to a novel aminothiazole derivatives. The TNIK inhibitors are showed by a next formula (I). Wherein R1, R2, R3, R4, R5 and R6 represent independently a hydrogen atom or a substituent group.
    Type: Application
    Filed: April 23, 2010
    Publication date: August 26, 2010
    Inventors: Tesshi Yamada, Miki Shitashige, Koichi Yokota, Masaaki Sawa, Hideki Moriyama
  • TNIK INHIBITOR AND THE USE
    Publication number: 20100137386
    Abstract: The present invention relates to compositions and methods for the treatment of cancer patients with Traf2- and Nck-interacting kinase (TNIK) inhibitors. More particularly, the present invention relates to pharmaceutical compositions comprising TNIK inhibitor and a pharmaceutically acceptable carrier, and to methods for treating the TNIK inhibitor administered to cancer patients, especially to solid cancer patients such as colorectal cancer, pancreatic cancer, non-small cell lung cancer, prostate cancer or breast cancer. And the present invention relates to a novel aminothiazole derivatives.
    Type: Application
    Filed: July 15, 2009
    Publication date: June 3, 2010
    Inventors: Tesshi YAMADA, Miki SHITASHIGE, Koichi YOKOTA, Masaaki SAWA, Hideki MORIYAMA
  • SCREENING METHOD FOR ANTICANCER DRUG
    Publication number: 20090215081
    Abstract: The screening method for an anticancer drug comprises selecting a compound which blocks the kinase activity of TNIK, or blocks the combination of TNIK with ?-catenin/TC4 transcription complex.
    Type: Application
    Filed: August 13, 2008
    Publication date: August 27, 2009
    Applicant: JAPAN HEALTH SCIENCES FOUNDATION
    Inventors: Tesshi Yamada, Miki Shitashige, Setsuo Hirohashi