Abstract: A process of producing particles for diagnostic reagent, including forming a matrix particle by mixing a nuclear particle having a CV value of 20% or less and a magnetic substance containing at least one of Fe2O3 and Fe3O4 and giving a shear force to the mixture to adsorb the magnetic substance on the surface of the nuclear particles; and polymerizing a polymerizable monomer in the presence of said matrix particle to form a polymer layer on the magnetic substance layer.

Abstract: A process of producing particles for diagnostic reagent, including forming a matrix particle by mixing a nuclear particle having a CV value of 20% or less and a magnetic substance containing at least one of Fe2O3 and Fe3O4 and giving a shear force to the mixture to adsorb the magnetic substance on the surface of the nuclear particles; and polymerizing a polymerizable monomer in the presence of said matrix particle to form a polymer layer on the magnetic substance layer.

Abstract: A process of producing particles for diagnostic reagent, including a step of polymerizing a polymerizable monomer in the presence of a matrix particle having a magnetic substance layer containing at least one of Fe2O3 and Fe3O4 on the surface thereof and having a mean particle size of 0.4-200 &mgr;m to form a polymer layer on the magnetic substance layer.

Abstract: A process of producing particles for diagnostic reagent, including a step of polymerizing a polymerizable monomer in the presence of a matrix particle having a magnetic substance layer containing at least one of Fe2O3 and Fe3O4 on the surface thereof and having a mean particle size of 0.4-200 &mgr;m to form a polymer layer on the magnetic substance layer.

Abstract: Particles capable of being bound by viruses, having a particle diameter of 0.05 &mgr;m to 300 &mgr;m and having either a cationic group or an anionic group or both at their surfaces. Also disclosed are a method of separating or detecting viruses and a virus-separating reagent, which make use of such particles. The particles enable simultaneous and simple treatment of a large number of specimens by a simple means.

Abstract: A particle for a diagnostic agent, which comprises a polymer particle comprising (A) from 20 to 100% by weight of a structural unit derived from at least one of acrylate having an aliphatic hydrocarbon group and methacrylate having an aliphatic hydrocarbon group, (B) from 0 to 10% by weight of a structural unit derived from unsaturated carboxylic acid, and (C) from 0 to 80% by weight of a structural unit derived from a vinyl monomer copolymerizable with the acrylate, methacrylate and unsaturated carboxylic acid, and a turbidmetric immunoassay using the same.

Abstract: Particles capable of being bound by viruses, having a particle diameter of 0.05 &mgr;m to 300 &mgr;m and having either a cationic group or an anionic group or both at their surfaces. Also disclosed are a method of separating or detecting viruses and a virus-separating reagent, which make use of such particles. The particles enable simultaneous and simple treatment of a large number of specimens by a simple means.

Abstract: A hybridization carrier, containing a single-stranded polynucleotide having the formula:5'-(dN).sub.n (dT).sub.m -3',wherein N represents admine, guanine or cytosin; T represents thymine; n is an integer of 2 or larger; and m is an integer of 5 or larger;the polynucleotide being immobilized by an amide bond on a surface of an organic polymers particle having a diameter of from about 0.05 .mu.m to about 5 .mu.m;the polynucleotide being immobilized at the site of a nucleotide sequence consisting of 2 or more polynucleotide which contain a primary amino residue in the polynucleotide; andthe amide bond having been formed between the primary amino residue and a carboxyl residue on the surface of the organic polymer particle.