Patents by Inventor Mikio Nakagawa

Mikio Nakagawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190369124
    Abstract: The present invention provides an agent for determining Alzheimer's disease, comprising an anti-S38AA antibody, a method of determining Alzheimer's disease in a test animal, comprising detecting an S38AA fragment in a sample collected from said animal, and a method of screening for a substance that treats or prevents Alzheimer's disease, comprising contacting a test substance with a cell permitting measurement of production of a S38AA fragment, measuring the production amount of the S38AA fragment in the cell, and comparing the production amount with that of the S38AA fragment in a control cell free of contact with the test substance, and selecting a test substance that down-regulates the production amount of the S38AA fragment as a substance capable of treating or preventing Alzheimer's disease, based on the comparison results.
    Type: Application
    Filed: August 19, 2019
    Publication date: December 5, 2019
    Applicant: Sumitomo Dainippon Pharma Co., Ltd.
    Inventors: Masakazu HASHIMOTO, Hiroyuki NAKAGAWA, Mikio AOKI, Lars O. TJERNBERG, Bengt WINBLAD
  • Patent number: 10393757
    Abstract: The present invention provides an agent for determining Alzheimer's disease, comprising an anti-S38AA antibody, a method of determining Alzheimer's disease in a test animal, comprising detecting an S38AA fragment in a sample collected from said animal, and a method of screening for a substance that treats or prevents Alzheimer's disease, comprising contacting a test substance with a cell permitting measurement of production of a S38AA fragment, measuring the production amount of the S38AA fragment in the cell, and comparing the production amount with that of the S38AA fragment in a control cell free of contact with the test substance, and selecting a test substance that down-regulates the production amount of the S38AA fragment as a substance capable of treating or preventing Alzheimer's disease, based on the comparison results.
    Type: Grant
    Filed: December 28, 2011
    Date of Patent: August 27, 2019
    Assignee: DAINIPPON SUMITOMO PHARMA CO., LTD.
    Inventors: Masakazu Hashimoto, Hiroyuki Nakagawa, Mikio Aoki, Lars O. Tjernberg, Bengt Winblad
  • Publication number: 20190134586
    Abstract: The present invention provides a supply system enabling a precursor of a solid material or a precursor of a liquid material to be supplied to a latter process at no higher concentration than required and also at or above a predetermined concentration. A supply system 1 comprises: a vessel 11 for receiving a precursor material; a vessel heating unit for heating the vessel at a set temperature; a carrier gas heating unit which is disposed in an introduction line L1 and heats a carrier gas; a main measurement unit which is disposed in an outward conduction line L2 and obtains data relating to a gas of the precursor; and a carrier gas temperature control unit for controlling the temperature of the carrier gas heating unit in accordance with a measurement result of the main measurement unit.
    Type: Application
    Filed: March 28, 2017
    Publication date: May 9, 2019
    Inventors: Toshiyuki NAKAGAWA, Kouki MORIMOTO, Kazutaka YANAGITA, Takashi KAMEOKA, Yuki KUMAMOTO, Kazuma SUZUKI, Mikio GOTO
  • Patent number: 10254645
    Abstract: There are provided a photosensitive resin composition having excellent chemical resistance, light resistance, and solubility in a solvent, a method for producing a cured film, a cured film, a liquid crystal display device, an organic electroluminescent display device, and a touch panel. The photosensitive resin composition contains a polybenzoxazole precursor, a photoacid generator which generates an acid having a pKa of 3 or less or a quinone diazide compound, and a solvent, in which the polybenzoxazole precursor contains a total of 70 mol % or more of a repeating unit represented by the following Formula (1) and a repeating unit represented by the following Formula (2) with respect to the total repeating units, and a ratio between the repeating unit represented by Formula (1) and the repeating unit represented by Formula (2) is 9:1 to 3:7 in a molar ratio. Y1 represents a cyclic aliphatic group having 3 to 15 carbon atoms, and Y2 represents a linear or branched aliphatic group having 4 to 20 carbon atoms.
    Type: Grant
    Filed: February 27, 2017
    Date of Patent: April 9, 2019
    Assignee: FUJIFILM Corporation
    Inventors: Kenta Yoshida, Takuma Amemiya, Satoru Yamada, Mikio Nakagawa
  • Patent number: 9932703
    Abstract: A carbon fiber sizing agent imparts good bonding performance to carbon fiber, is used to reinforce a thermoplastic matrix resin, and provides a carbon fiber strand applied with the sizing agent and a fiber-reinforced composite reinforced with the carbon fiber strand. The sizing agent for carbon fiber is used to reinforce thermoplastic matrix resin. The sizing agent essentially contains a polymer component having a glass transition temperature of at least 20 deg.C. and exhibits no endothermic peaks indicating an endothermic heat of fusion due to crystalline melting of at least 3 J/g in a determination with a DSC. The weight ratio of the polymer component is 10 to 100 wt % of the nonvolatile components of the sizing agent. The polymer component is at least one component selected from the group consisting of an aromatic polyester resin, aromatic polyester-polyurethane resin and amine-modified aromatic epoxy resin.
    Type: Grant
    Filed: October 15, 2012
    Date of Patent: April 3, 2018
    Assignee: MATSUMOTO YUSHI-SEIYAKU CO., LTD.
    Inventors: Yoshio Hashimoto, Yusuke Shimizu, Mikio Nakagawa
  • Publication number: 20170168391
    Abstract: There are provided a photosensitive resin composition having excellent chemical resistance, light resistance, and solubility in a solvent, a method for producing a cured film, a cured film, a liquid crystal display device, an organic electroluminescent display device, and a touch panel. The photosensitive resin composition contains a polybenzoxazole precursor, a photoacid generator which generates an acid having a pKa of 3 or less or a quinone diazide compound, and a solvent, in which the polybenzoxazole precursor contains a total of 70 mol % or more of a repeating unit represented by the following Formula (1) and a repeating unit represented by the following Formula (2) with respect to the total repeating units, and a ratio between the repeating unit represented by Formula (1) and the repeating unit represented by Formula (2) is 9:1 to 3:7 in a molar ratio. Y1 represents a cyclic aliphatic group having 3 to 15 carbon atoms, and Y2 represents a linear or branched aliphatic group having 4 to 20 carbon atoms.
    Type: Application
    Filed: February 27, 2017
    Publication date: June 15, 2017
    Applicant: FUJIFILM Corporation
    Inventors: Kenta YOSHIDA, Takuma AMEMIYA, Satoru YAMADA, Mikio NAKAGAWA
  • Publication number: 20170090072
    Abstract: The invention is directed to a polarizing plate protective film containing a polymer having at least one of an ester bond and an amide bond and a compound which generates a base by an action of an acid, a polarizing plate including the polarizing plate protective film and a polarizer, a liquid crystal display device including a liquid crystal cell and the polarizing plate, and a production method of a polarizing plate protective film including producing the Polarizing plate protective film with a composition containing a polymer having at least one of an ester bond and an amide bond and a compound which generates a base by an action of an acid.
    Type: Application
    Filed: September 29, 2016
    Publication date: March 30, 2017
    Applicant: FUJIFILM Corporation
    Inventors: Yoshinori MAEDA, Mikio NAKAGAWA
  • Patent number: 9234312
    Abstract: A sizing agent for a reinforcement fiber is used for reinforcing thermoplastic matrix resins and spreads on the reinforcement fiber surface and imparts both excellent splittability and bonding performance to thermoplastic matrix resins. The sizing agent includes essentially an ester compound (A) having a vinyl ester group, acrylate group or methacrylate group bonded to at least one of the chain ends of the main chain of the ester compound (A), and of a polyoxyalkylene alkyl ether (B) which is an adduct between an alkylene oxide and a C4-14 monohydric alcohol. When water is added to the sizing agent thereby producing a mixture with a nonvolatile content of 1 weight %, the mixture exhibits a dynamic surface tension ranging from 40 to 55 mN/m determined by the maximum bubble pressure method when bubbles are blown into the mixture at the rate of one bubble per 100 milliseconds.
    Type: Grant
    Filed: February 27, 2013
    Date of Patent: January 12, 2016
    Assignee: MATSUMOTO YUSHI-SEIYAKU CO., LTD.
    Inventors: Toshihiko Kikuta, Masahiko Yoshida, Jun Takaya, Mikio Nakagawa
  • Patent number: 9223211
    Abstract: Provided is a photosensitive resin composition having high sensitivity and storage stability.
    Type: Grant
    Filed: January 28, 2015
    Date of Patent: December 29, 2015
    Assignee: FUJIFILM Corporation
    Inventors: Kyouhei Sakita, Shinji Fujimoto, Mikio Nakagawa, Kenta Yamazaki
  • Patent number: 9200384
    Abstract: An acrylic-fiber finish for carbon fiber production is prepared into a stable emulsion and applied to a carbon-fiber precursor to prevent gumming up of finish components in precursor production and carbon fiber fusing in baking process. The acrylic-fiber finish is used for carbon-fiber production and includes a modified silicone having a modifying group containing a nitrogen atom and an acidic phosphate ester represented by the following chemical formula (1). where R1 represents a C6-22 alkyl or alkenyl group, A represents a C2-4 alkylene group, and AO represents an oxyalkylene group, n represents a mole number of oxyalkylene group and is an integer ranging from 0 to 20, and each of a and b is an integer of 1 or 2 and meets the equation a+b=3.
    Type: Grant
    Filed: February 14, 2013
    Date of Patent: December 1, 2015
    Assignee: MATSUMOTO YUSHI-SEIYAKU CO., LTD.
    Inventors: Yoshio Hashimoto, Takeyoshi Nakayama, Jun Takaya, Mikio Nakagawa
  • Patent number: 9068054
    Abstract: A sizing agent for reinforcement fibers which imparts good bonding performance to a reinforcement fiber is used to reinforce thermoplastic matrix resin, and provide a synthetic fiber strand applied with the sizing agent and a fiber-reinforced composite reinforced with the synthetic fiber strand. The sizing agent essentially contains a neutralization product of a modified polypropylene resin and an amine compound having at least two hydroxyl groups or amino groups in the molecule, and the nonvolatile component of the sizing agent exhibits an endothermic heat of fusion not higher than 50 J/g in determination with a differential scanning calorimeter (DSC).
    Type: Grant
    Filed: July 27, 2011
    Date of Patent: June 30, 2015
    Assignee: MATSUMOTO YUSHI-SEIYAKU CO., LTD.
    Inventors: Yoshio Hashimoto, Yusuke Shimizu, Mikio Nakagawa
  • Publication number: 20150148546
    Abstract: Provided is a photosensitive resin composition having high sensitivity and storage stability.
    Type: Application
    Filed: January 28, 2015
    Publication date: May 28, 2015
    Applicant: FUJIFILM Corporation
    Inventors: Kyouhei SAKITA, Shinji FUJIMOTO, Mikio NAKAGAWA, Kenta YAMAZAKI
  • Publication number: 20150044125
    Abstract: An acrylic-fiber finish for carbon fiber production is prepared into a stable emulsion and applied to a carbon-fiber precursor to prevent gumming up of finish components in precursor production and carbon fiber fusing in baking process. The acrylic-fiber finish is used for carbon-fiber production and includes a modified silicone having a modifying group containing a nitrogen atom and an acidic phosphate ester represented by the following chemical formula (1). where R1 represents a C6-22 alkyl or alkenyl group, A represents a C2-4 alkylene group, and AO represents an oxyalkylene group, n represents a mole number of oxyalkylene group and is an integer ranging from 0 to 20, and each of a and b is an integer of 1 or 2 and meets the equation a+b=3.
    Type: Application
    Filed: February 14, 2013
    Publication date: February 12, 2015
    Applicant: MATSUMOTO YUSHI-SEIYAKU CO., LTD.
    Inventors: Yoshio Hashimoto, Takeyoshi Nakayama, Jun Takaya, Mikio Nakagawa
  • Publication number: 20150018451
    Abstract: The present invention aims to provide a sizing agent for a reinforcement fiber used for reinforcing thermoplastic matrix resins. The sizing agent uniformly spreads on reinforcement fiber surface and imparts, to a reinforcement fiber, both excellent splittability and bonding performance to thermoplastic matrix resins. The sizing agent for a reinforcement fiber of the present invention comprises essentially an ester compound (A) having a vinyl ester group, acrylate group or methacrylate group bonded to at least one of the chain ends of the main chain of the ester compound (A), and of a polyoxyalkylene alkyl ether (B) which is an adduct between an alkylene oxide and a C4-14 monohydric alcohol. When water is added to the sizing agent thereby producing a mixture with a nonvolatile content of 1 weight %, the mixture exhibits a dynamic surface tension ranging from 40 to 55 mN/m determined by the maximum bubble pressure method when bubbles are blown into the mixture at the rate of one bubble per 100 milliseconds.
    Type: Application
    Filed: February 27, 2013
    Publication date: January 15, 2015
    Inventors: Toshihiko Kikuta, Masahiko Yoshida, Jun Takaya, Mikio Nakagawa
  • Patent number: 8852684
    Abstract: A finish for acrylic fiber to be processed into carbon fiber includes an ester compound having at least three ester groups in its molecule and a silicone compound, wherein the silicone compound constitutes 10 to 50 weight percent of the whole of the nonvolatile matter of the finish. A method of manufacturing carbon fiber includes the processes of applying the finish for acrylic fiber to be processed into carbon fiber to acrylic fiber to be processed into carbon fiber; oxidative-stabilizing the finish-applied acrylic fiber in an oxidizing atmosphere at 200 to 300 deg. C. to convert the fiber into oxidized fiber; and carbonizing the oxidized fiber in an inert atmosphere at 200 to 3000 deg. C.
    Type: Grant
    Filed: November 16, 2006
    Date of Patent: October 7, 2014
    Assignee: Matsumoto Yushi-Seiyaku Co., Ltd.
    Inventors: Yoshinobu Okabe, Yoshiaki Tanaka, Yoshio Hashimoto, Mikio Nakagawa
  • Publication number: 20140227516
    Abstract: A carbon fiber sizing agent imparts good bonding performance to carbon fiber, is used to reinforce a thermoplastic matrix resin, and provides a carbon fiber strand applied with the sizing agent and a fiber-reinforced composite reinforced with the carbon fiber strand. The sizing agent for carbon fiber is used to reinforce thermoplastic matrix resin. The sizing agent essentially contains a polymer component having a glass transition temperature of at least 20 deg.C. and exhibits no endothermic peaks indicating an endothermic heat of fusion due to crystalline melting of at least 3 J/g in a determination with a DSC. The weight ratio of the polymer component is 10 to 100 wt % of the nonvolatile components of the sizing agent. The polymer component is at least one component selected from the group consisting of an aromatic polyester resin, aromatic polyester-polyurethane resin and amine-modified aromatic epoxy resin.
    Type: Application
    Filed: October 15, 2012
    Publication date: August 14, 2014
    Inventors: Yoshio Hashimoto, Yusuke Shimizu, Mikio Nakagawa
  • Publication number: 20130123407
    Abstract: A sizing agent for reinforcement fibers which imparts good bonding performance to a reinforcement fiber is used to reinforce thermoplastic matrix resin, and provide a synthetic fiber strand applied with the sizing agent and a fiber-reinforced composite reinforced with the synthetic fiber strand. The sizing agent essentially contains a neutralization product of a modified polypropylene resin and an amine compound having at least two hydroxyl groups or amino groups in the molecule, and the nonvolatile component of the sizing agent exhibits an endothermic heat of fusion not higher than 50 J/g in determination with a differential scanning calorimeter (DSC).
    Type: Application
    Filed: July 27, 2011
    Publication date: May 16, 2013
    Applicant: MATSUMOTO YUSHI-SEIYAKU CO., LTD.
    Inventors: Yoshio Hashimoto, Yusuke Shimizu, Mikio Nakagawa
  • Patent number: 8323743
    Abstract: An acrylic-fiber finish for use in carbon-fiber production contributes to high tenacity of resultant carbon fiber. The acrylic-fiber finish for carbon-fiber production includes an epoxy-polyether-modified silicone and a surfactant. The weight ratios of the epoxy-polyether-modified silicone and the surfactant in the total of the non-volatile components of the finish respectively range from 1 to 95 wt % and from 5 to 50 wt %. The carbon fiber production method includes a fiber production process for producing an acrylic fiber for carbon-fiber production by applying the finish to an acrylic fiber which is a basic material for the acrylic fiber for carbon-fiber production; an oxidative stabilization process for converting the acrylic fiber produced in the fiber production process into oxidized fiber in an oxidative atmosphere at 200 to 300 deg.C.; and a carbonization process for carbonizing the oxidized fiber in an inert atmosphere at 300 to 2,000 deg.C.
    Type: Grant
    Filed: May 21, 2010
    Date of Patent: December 4, 2012
    Assignee: Matsumoto Yushi-Seiyaku Co., Ltd.
    Inventors: Takeyoshi Nakayama, Yoshio Hashimoto, Mikio Nakagawa
  • Publication number: 20120021125
    Abstract: An acrylic-fiber finish for use in carbon-fiber production contributes to high tenacity of resultant carbon fiber. The acrylic-fiber finish for carbon-fiber production includes an epoxy-polyether-modified silicone and a surfactant. The weight ratios of the epoxy-polyether-modified silicone and the surfactant in the total of the non-volatile components of the finish respectively range from 1 to 95 wt % and from 5 to 50 wt %. The carbon fiber production method includes a fiber production process for producing an acrylic fiber for carbon-fiber production by applying the finish to an acrylic fiber which is a basic material for the acrylic fiber for carbon-fiber production; an oxidative stabilization process for converting the acrylic fiber produced in the fiber production process into oxidized fiber in an oxidative atmosphere at 200 to 300 deg.C.; and a carbonization process for carbonizing the oxidized fiber in an inert atmosphere at 300 to 2,000 deg.C.
    Type: Application
    Filed: May 21, 2010
    Publication date: January 26, 2012
    Applicant: MATSUMOTO YUSHI-SEIYAKU CO., LTD.
    Inventors: Takeyoshi Nakayama, Yoshio Hashimoto, Mikio Nakagawa
  • Publication number: 20090263576
    Abstract: A finish for acrylic fiber to be processed into carbon fiber includes an ester compound having at least three ester groups in its molecule and a silicone compound, wherein the silicone compound constitutes 10 to 50 weight percent of the whole of the nonvolatile matter of the finish. A method of manufacturing carbon fiber includes the processes of applying the finish for acrylic fiber to be processed into carbon fiber to acrylic fiber to be processed into carbon fiber; oxidative-stabilizing the finish-applied acrylic fiber in an oxidizing atmosphere at 200 to 300 deg. C. to convert the fiber into oxidized fiber; and carbonizing the oxidized fiber in an inert atmosphere at 200 to 3000 deg. C.
    Type: Application
    Filed: November 16, 2006
    Publication date: October 22, 2009
    Applicant: MATSUMOTO YUSHI-SEIYAKU CO., LTD.
    Inventors: Yoshinobu Okabe, Yoshiaki Tanaka, Yoshio Hashimoto, Mikio Nakagawa