Abstract: Provided is a substance capable of effectively suppressing cancer metastasis or a pharmaceutical composition that effectively acts on an inflammatory disease. The pharmaceutical composition is a pharmaceutical composition containing, as an active ingredient, an antibody or an antibody fragment thereof having antigen-binding activity for an S100A8/A9 heterodimer, and blocks interaction between S100A8/A9 and a group of receptors therefor, to thereby strongly suppress cancer metastasis both in vitro and in vivo, or alleviate inflammation. That is, the anti-S100A8/A9 antibody or the antibody fragment thereof can strongly suppress cancer metastasis or alleviate inflammation, by virtue of its blocking action on the interaction between S100A8/A9 and the group of receptors therefor.

Abstract: Provided is a substance capable of effectively suppressing cancer metastasis or a pharmaceutical composition that effectively acts on an inflammatory disease. The pharmaceutical composition is a pharmaceutical composition containing, as an active ingredient, an antibody or an antibody fragment thereof having antigen-binding activity for an S100A8/A9 heterodimer, and blocks interaction between S100A8/A9 and a group of receptors therefor, to thereby strongly suppress cancer metastasis both in vitro and in vivo, or alleviate inflammation. That is, the anti-S100A8/A9 antibody or the antibody fragment thereof can strongly suppress cancer metastasis or alleviate inflammation, by virtue of its blocking action on the interaction between S100A8/A9 and the group of receptors therefor.

Abstract: Provided is a substance capable of effectively suppressing cancer metastasis or a pharmaceutical composition that effectively acts on an inflammatory disease. The pharmaceutical composition is a pharmaceutical composition containing, as an active ingredient, an antibody or an antibody fragment thereof having antigen-binding activity for an S100A8/A9 heterodimer, and blocks interaction between S100A8/A9 and a group of receptors therefor, to thereby strongly suppress cancer metastasis both in vitro and in vivo, or alleviate inflammation. That is, the anti-S100A8/A9 antibody or the antibody fragment thereof can strongly suppress cancer metastasis or alleviate inflammation, by virtue of its blocking action on the interaction between S100A8/A9 and the group of receptors therefor.

Abstract: Provided is an engagement measurement system with which it is possible to measure and totalize how much students or an audience is interested in a lesson or a lecture in real time. An engagement measurement device captures images of a plurality of students who are subjects using a single or a small number of imaging devices, and measures an engagement value that indicates how much the students are interest in a lesson. The engagement measurement device records subject IDs, the date and time information, and the engagement value in a log table.

Abstract: An engagement value processing system is provided which can simultaneously acquire biological information such as a pulse in addition to an engagement value by using only video data obtained from an imaging apparatus. In an image data stream outputted by the imaging apparatus, feature data indicating features of a face is generated by a feature extraction unit. A face direction vector and a line-of-sight direction vector for calculating an engagement value of a user for a content are calculated from the feature data. On the other hand, the feature data can also be used to cut out partial image data for detecting a pulse and estimate the emotion of the user. Therefore, the engagement value for the content, the pulse, and the emotion of the user viewing the content can be simultaneously acquired simply by capturing the user with the imaging apparatus.