Patents by Inventor Mikio Taniguchi

Mikio Taniguchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Dolastatin 10 derivatives
    Patent number: 6737409
    Abstract: Novel anti-tumor compounds of formula, are disclosed. Also disclosed are pharmaceutical compositions comprising compounds of formula (I), the use of compounds of formula (I) for the treatment of cancer, and processes for the preparation of compounds (I).
    Type: Grant
    Filed: July 15, 2002
    Date of Patent: May 18, 2004
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Toshihiko Fujii, Takehiro Okada, Mikio Taniguchi, Fumio Watanabe
  • Dolastatin 10 derivatives
    Publication number: 20030055002
    Abstract: Novel anti-tumor compounds of formula, 1
    Type: Application
    Filed: July 15, 2002
    Publication date: March 20, 2003
    Inventors: Toshihiko Fujii, Takehiro Okada, Mikio Taniguchi, Fumio Watanabe
  • Process for producing imidazole derivative
    Patent number: 6005105
    Abstract: The present invention is directed to a process for preparing the following compound ##STR1## which is prepared starting from ##STR2## which is reacted succesively with 4-iodobenzyl or 4-bromobenzyl bromide, hydrazine and 1,4-dimethyl-1,3-cyclohexadiene, reduced and reacted with phenyltetrazole or suitably protected phenyltetrazole followed by removal
    Type: Grant
    Filed: December 6, 1995
    Date of Patent: December 21, 1999
    Assignee: Pharmacia & Upjohn Company
    Inventors: Hiroyoshi Yamada, Kiyotaka Munesada, Keiko Koh, Kazuo Tsuzuki, Mikio Taniguchi, Yoshiji Fujita
  • Phenyloxazolidinone antimicrobials
    Patent number: 5883093
    Abstract: The present invention relates to antimicrobial phenyloxazolidinone compounds having a pyrrolidinyl or azetidinyl moiety.
    Type: Grant
    Filed: April 23, 1997
    Date of Patent: March 16, 1999
    Assignee: Pharmacia & Upjohn Company
    Inventors: Douglas K. Hutchinson, Steven J. Brickner, Michael R. Barbachyn, Mikio Taniguchi, Kiyotaka Munesada, Hiroyoshi Yamada
  • Tropolone derivatives and pharmaceutical composition thereof for preventing and treating ischemic diseases
    Patent number: 5703071
    Abstract: The present invention provides novel tropolone derivatives of the formula I ##STR1## wherein R.sub.10 is a substituted or unsubstituted piperazinyl or benzothiazolidinyl group, and pharamaceutical compositions thereof. These compounds are useful for the prevention and treatment of ischemic diseases, including cerebrovascular diseases and cardiovascular diseases.
    Type: Grant
    Filed: May 18, 1995
    Date of Patent: December 30, 1997
    Assignee: Pharmacia & Upjohn Company
    Inventors: Noriie Itoh, Mineo Kunihara, Hiroshi Kushida, William W. McWhorter, Syunji Nomura, Kazunori Ozawa, Mikio Taniguchi, Kazuo Tsuzuki
  • Oxazolidinone derivatives and pharmaceutical compositions containing them
    Patent number: 5668286
    Abstract: The present invention provides agents having high antimicrobial activity for preventing and treating infectious diseases. Thus, the present invention provides novel oxazolidinone derivatives represented by chemical formula (I), or pharmaceutically acceptable salts thereof, as well as antimicrobial compositions containing said derivatives or salts thereof as active ingredients.
    Type: Grant
    Filed: September 9, 1996
    Date of Patent: September 16, 1997
    Assignee: Pharmacia & Upjohn Company
    Inventors: Hiroyoshi Yamada, Kiyotaka Munesada, Mikio Taniguchi
  • Tropolone derivatives and pharmaceutical composition thereof for preventing and treating ischemic diseases
    Patent number: 5594144
    Abstract: The present invention provides novel tropolone derivatives of the formula I ##STR1## wherein R.sub.10 is a substituted or unsubstituted piperazinyl or benzothiazolidinyl group, and pharamaceutical compositions thereof. These compounds are useful for the prevention and treatment of ischemic diseases, including cerebrovascular diseases and cardiovascular diseases.
    Type: Grant
    Filed: May 18, 1995
    Date of Patent: January 14, 1997
    Assignee: The Upjohn Company
    Inventors: Noriie Itoh, Mineo Kunihara, Hiroshi Kushida, William W. McWhorter, Syunji Nomura, Kazunori Ozawa, Mikio Taniguchi, Kazuo Tsuzuki
  • Imidazole derivatives and pharmaceutical compositions containing the same
    Patent number: 5442062
    Abstract: The present invention provides a novel imidazole derivative having the chemical formula ##STR1## These compounds are useful for preventing or treating hypertension or congestive heart failure and have high activity, rapid action upon intravenous injection, good oral absorbtion, low toxicity, and long-lasting action. Also provided are pharmaceutical compositions which contain these compounds.
    Type: Grant
    Filed: April 22, 1994
    Date of Patent: August 15, 1995
    Assignee: The Upjohn Company
    Inventors: Keiko Koh, Mikio Taniguchi, Noriie Itoh, Hiroshi Kushida, Osamu Morita, Hiroyoshi Yamada, Kiyotaka Munesada, Kazuo Tsuzuki, Mineo Kunihara, Yoshiji Fujita