Patents by Inventor Mikito Takefuji

Mikito Takefuji has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fused cyclic urea derivatives as CRHR2 antagonist
    Patent number: 11802120
    Abstract: The present invention relates to fused cyclic urea derivatives which have antagonistic activities against CRHR1 and/or CRHR2, and which are useful in the treatment or prevention of disorders and diseases in which CRHR1 and/or CRHR2 is involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CRHR1 and/or CRHR2 is involved.
    Type: Grant
    Filed: April 9, 2019
    Date of Patent: October 31, 2023
    Assignee: RaQualia Pharma Inc.
    Inventors: Masashi Ohmi, Takeshi Matsushita, Kazuo Ando, Ryuichi Yamaguchi, Yutaka Fukumoto, Ryohei Magara, Tatsuya Yamagishi, Mikito Takefuji
  • METHOD FOR PREVENTING OR TREATING HEART FAILURE BY ADMINISTERING A MEDICAMENT CONTAINING AN ANTAGONIST OF CORTICOTROPIN RELEASING HORMONE RECEPTOR 2 (CRHR2)
    Publication number: 20210379158
    Abstract: A medicament for preventing or treating heart failure containing an antagonist of the corticotropin releasing hormone receptor 2 as an active ingredient.
    Type: Application
    Filed: August 17, 2021
    Publication date: December 9, 2021
    Inventor: Mikito TAKEFUJI
  • Method for preventing or treating heart failure by administering a medicament containing an antagonist of corticotropin releasing hormone receptor 2 (CRHR2)
    Patent number: 11135270
    Abstract: A medicament for preventing or treating heart failure containing an antagonist of the corticotropin releasing hormone receptor 2 as an active ingredient.
    Type: Grant
    Filed: November 23, 2018
    Date of Patent: October 5, 2021
    Assignee: RAQUALIA PHARMA INC.
    Inventor: Mikito Takefuji
  • FUSED CYCLIC UREA DERIVATIVES AS CRHR2 ANTAGONIST
    Publication number: 20210078975
    Abstract: The present invention relates to fused cyclic urea derivatives which have antagonistic activities against CRHR1 and/or CRHR2, and which are useful in the treatment or prevention of disorders and diseases in which CRHR1 and/or CRHR2 is involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CRHR1 and/or CRHR2 is involved.
    Type: Application
    Filed: April 9, 2019
    Publication date: March 18, 2021
    Applicants: RaQualia Pharma Inc., National University Corporation Tokai National Higher Education and Research System
    Inventors: Masashi OHMI, Takeshi MATSUSHITA, Kazuo ANDO, Ryuichi YAMAGUCHI, Yutaka FUKUMOTO, Ryohei MAGARA, Tatsuya YAMAGISHI, Mikito TAKEFUJI
  • MEDICAMENT FOR PREVENTING OR TREATING HEART FAILURE
    Publication number: 20190160151
    Abstract: A medicament for preventing or treating heart failure containing an antagonist of the corticotropin releasing hormone receptor 2 as an active ingredient.
    Type: Application
    Filed: November 23, 2018
    Publication date: May 30, 2019
    Applicant: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY
    Inventor: Mikito TAKEFUJI
  • RHOGEF12 IS A THERAPEUTIC TARGET FOR THE TREATMENT OF HEART FAILURE
    Publication number: 20150031622
    Abstract: The present invention relates to an inhibitor of the Rho guanine nucleotide exchange factor 12 (RhoGEF12) or an inhibitor of an activator of RhoGEF12 for use in the prevention and/or treatment of heart failure associated with cardiac hypertrophy and/or cardiac fibrosis and diseases associated therewith. Further, it relates also a method of treatment and methods for identifying inhibitors of Rho guanine nucleotide exchange factor 12 (RhoGEF12) or inhibitors of an activator of RhoGEF12.
    Type: Application
    Filed: March 1, 2013
    Publication date: January 29, 2015
    Inventors: Mikito Takefuji, Nina Wettschureck, Stefan Offermanns