Patents by Inventor Mikiya Sato

Mikiya Sato has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • POLYETHYLENE GLYCOL-MODIFIED FORM OF HEPATOCYTE GROWTH FACTOR OR ACTIVE FRAGMENT THEREOF
    Publication number: 20220220176
    Abstract: A variant of a hepatocyte growth factor or an active fragment thereof reduces the liver tropism and selectively exert bioactivity in a target tissue in disease other than a liver tissue. A polyethylene glycol-modified form of a hepatocyte growth factor or an active fragment thereof has polyethylene glycol(s) bound to (a) terminus(es) of the hepatocyte growth factor or the active fragment thereof via (a) protease-sensitive peptide(s).
    Type: Application
    Filed: January 28, 2020
    Publication date: July 14, 2022
    Inventors: Takashi Serizawa, Katsuyuki Mori, Tomomi Asano, Mikiya Sato
  • POLYETHYLENE GLYCOL-MODIFIED FORM OF HEPATOCYTE GROWTH FACTOR OR ACTIVE FRAGMENT THEREOF
    Publication number: 20220118050
    Abstract: A polyethylene glycol-modified form of a hepatocyte growth factor or an active fragment thereof achieves both an in vivo half-life extending effect of polyethylene glycol modification and the retainment of bioactivity. The polyethylene glycol-modified form of a hepatocyte growth factor or an active fragment thereof has one molecule of forked-type polyethylene glycol covalently bound to two molecules of the hepatocyte growth factor or the active fragment thereof at each of their respective carboxyl-terminal regions to form a homodimer.
    Type: Application
    Filed: January 28, 2020
    Publication date: April 21, 2022
    Inventors: Takashi Serizawa, Hideki Narumi, Katsuyuki Mori, Mikiya Sato