Abstract: 1. A capsule device (100) suitable for swallowing into a lumen of a gastrointestinal tract of a patient and for intestinal delivery of a therapeutic substance from the capsule device, wherein the capsule device (100) comprises: a) a housing portion (110, 115, 120), b) an activation element (130) movable relative to the housing portion from an expanded pre-delivery configuration into a non-expanded delivery configuration, c) a therapeutic substance comprised in a reservoir (A), and d) a delivery assembly comprising an actuator (140) comprising a potential energy source and a delivery outlet (190). The activation element (130) is movable by intestinal wall peristaltic contraction from the ex-panded pre-delivery configuration into the non-expanded delivery configuration to cause the actuator (140) to deliver the therapeutic substance through the delivery outlet (190).