Patents by Inventor Mikkel Thygesen

Mikkel Thygesen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANDROGEN RECEPTOR MODULATORS AND METHOD OF TREATING DISEASE USING THE SAME
    Publication number: 20080009489
    Abstract: Disclosed herein are bicycloaryl compounds of Formula (I) that selectively modulate nuclear receptors, preferably the androgen receptor, or a pharmaceutically acceptable salt, ester, amide, or prodrug thereof, and methods of treating disease comprising administering a compound of Formula (I) to a patient in need thereof.
    Type: Application
    Filed: June 28, 2007
    Publication date: January 10, 2008
    Applicant: Acadian Pharmaceuticals, Inc.
    Inventors: Nathalie Schlienger, Jan Pawlas, Alma Fejzic, Roger Olsson, Birgitte Lund, Fabrizio Badalassi, Rasmus Lewinsky, Mikkel Thygesen
  • PHARMACEUTICAL FORMULATIONS OF PIMAVANSERIN
    Publication number: 20070264330
    Abstract: Disclosed herein are stable pharmaceutical formulations of pimavanserin, which is useful for treating conditions associated with serotonin receptors.
    Type: Application
    Filed: May 15, 2007
    Publication date: November 15, 2007
    Inventors: Bo Ragnar-Tolf, Nathalie Schlienger, Mikkel Thygesen
  • SYNTHESIS OF N-(4-FLUOROBENZYL)-N-(1-METHYLPIPERIDIN-4-YL)-N'-(4-(2-METHYLPROPYLOXY)PHENYLMETHYL)CARBAMIDE AND ITS TARTRATE SALT AND CRYSTALLINE FORMS
    Publication number: 20070260064
    Abstract: Disclosed herein are methods for synthesizing N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)phenylmethyl)carbamide. Also disclosed herein is the hemi-tartrate salt of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and methods for obtaining the salt. Further disclosed are various crystalline forms of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its hemi-tartrate salt including various polymorphs and solvates.
    Type: Application
    Filed: May 15, 2007
    Publication date: November 8, 2007
    Inventors: Bo-Ragnar Tolf, Nathalie Schlienger, Mikkel Thygesen
  • Androgen receptor modulators and methods of treating disease using the same
    Publication number: 20070004679
    Abstract: Disclosed herein are bicycloaryl compounds of Formula (I) that selectively modulate nuclear receptors, preferably the androgen receptor, or a pharmaceutically acceptable salt, ester, amide, or prodrug thereof, and methods of treating disease comprising administering a compound of Formula (I) to a patient in need thereof.
    Type: Application
    Filed: February 6, 2006
    Publication date: January 4, 2007
    Inventors: Nathalie Schlienger, Jan Pawlas, Alma Fejzic, Roger Olsson, Birgitte Lund, Fabrizio Badalassi, Rasmus Lewinsky, Mikkel Thygesen, Douglas Bonhaus
  • Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms
    Publication number: 20060205780
    Abstract: Disclosed herein are methods for synthesizing N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide. Also disclosed herein is the hemi-tartrate salt of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and methods for obtaining the salt. Further disclosed are various crystalline forms of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and its hemi-tartrate salt including various polymorphs and solvates.
    Type: Application
    Filed: May 3, 2006
    Publication date: September 14, 2006
    Inventors: Mikkel Thygesen, Nathalie Schlienger, Bo-Ragnar Tolf, Carl-Magnus Andersson, Fritz Blatter, Jorg Berghausen
  • Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms
    Publication number: 20060205781
    Abstract: Disclosed herein are methods for synthesizing N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide. Also disclosed herein is the hemi-tartrate salt of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and methods for obtaining the salt. Further disclosed are various crystalline forms of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and its hemi-tartrate salt including various polymorphs and solvates.
    Type: Application
    Filed: May 3, 2006
    Publication date: September 14, 2006
    Inventors: Mikkel Thygesen, Nathalie Schlienger, Bo-Ragnar Tolf, Carl-Magnus Andersson, Fritz Blatter, Jorg Berghausen
  • Method of synthesis and isolation of solid N-desmethylclozapine and crystalline forms thereof
    Publication number: 20060205714
    Abstract: Disclosed herein are crystalline Forms A, B, C, D, and E of N-desmethylclozapine, methods of preparing the same, pharmaceutical compositions comprising the same, and methods of therapeutic treatment involving N-desmethylclozapine polymorphic forms.
    Type: Application
    Filed: May 3, 2006
    Publication date: September 14, 2006
    Inventors: Bo-Ragnar Tolf, Mikkel Thygesen, Fritz Blatter, Jorg Berghausen
  • Method of synthesis and isolation of solid N-desmethylclozapine and crystalline forms thereof
    Publication number: 20060199808
    Abstract: Disclosed herein are crystalline Forms A, B, C, D, and E of N-desmethylclozapine, methods of preparing the same, pharmaceutical compositions comprising the same, and methods of therapeutic treatment involving N-desmethylclozapine polymorphic forms.
    Type: Application
    Filed: May 3, 2006
    Publication date: September 7, 2006
    Inventors: Bo-Ragnar Tolf, Mikkel Thygesen, Fritz Blatter, Jorg Berghausen
  • Aminophenyl derivatives as selective androgen receptor modulators
    Publication number: 20060173037
    Abstract: Disclosed herein is a novel class of aminophenyl compounds having the structure: wherein R1 is cyano or nitro and ring A is a bi- or tricyclic bridged heterocycle and to their use as modulators of androgen receptor for the treatment or prevention of conditions relating thereto.
    Type: Application
    Filed: February 6, 2006
    Publication date: August 3, 2006
    Inventors: Nathalie Schlienger, Mikkel Thygesen, Jan Pawlas, Fabrizio Badalassi, Rasmus Lewinsky, Birgitte Lund, Roger Olsson
  • Aminophenyl derivatives as selective androgen receptor modulators
    Publication number: 20060160845
    Abstract: Disclosed herein is a novel class of aminophenyl compounds having the structure: wherein R1 is cyano or nitro and ring A is a bi- or tricyclic bridged heterocycle and to their use as modulators of androgen receptor for the treatment or prevention of conditions relating thereto.
    Type: Application
    Filed: January 9, 2006
    Publication date: July 20, 2006
    Inventors: Nathalie Schlienger, Mikkel Thygesen, Jan Pawlas, Fabrizio Badalassi, Rasmus Lewinsky, Birgitte Lund, Roger Olsson
  • Salts of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl)carbamide and their preparation
    Publication number: 20060111399
    Abstract: Disclosed herein are salts of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)phenylmethyl)carbamide including the citrate, fumarate, maleate, malate, phosphate, succinate, sulphate, and edisylate salts.
    Type: Application
    Filed: September 26, 2005
    Publication date: May 25, 2006
    Inventors: Mikkel Thygesen, Nathalie Schlienger, Bo-Ragnar Tolf, Fritz Blatter, Jorg Berghausen
  • Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms
    Publication number: 20060106063
    Abstract: Disclosed herein are methods for synthesizing N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide. Also disclosed herein is the hemi-tartrate salt of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and methods for obtaining the salt. Further disclosed are various crystalline forms of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and its hemi-tartrate salt including various polymorphs and solvates.
    Type: Application
    Filed: September 26, 2005
    Publication date: May 18, 2006
    Inventors: Mikkel Thygesen, Nathalie Schlienger, Bo-Ragnar Tolf, Carl-Magnus Andersson, Fritz Blatter, Jorg Berghausen
  • Androgen receptor modulators and method of treating disease using the same
    Publication number: 20060014739
    Abstract: Disclosed herein are bicycloaryl compounds of Formula (I) that selectively modulate nuclear receptors, preferably the androgen receptor, or a pharmaceutically acceptable salt, ester, amide, or prodrug thereof, and methods of treating disease comprising administering a compound of Formula (I) to a patient in need thereof.
    Type: Application
    Filed: May 16, 2005
    Publication date: January 19, 2006
    Inventors: Nathalie Schlienger, Jan Pawlas, Alma Fejzic, Roger Olsson, Birgitte Lund, Fabrizio Badalassi, Rasmus Lewinsky, Mikkel Thygesen
  • Method of synthesis and isolation of solid N-desmethylclozapine and crystalline forms thereof
    Publication number: 20050282800
    Abstract: Disclosed herein are crystalline Forms A, B, C, D, and E of N-desmethylclozapine, methods of preparing the same, pharmaceutical compositions comprising the same, and methods of therapeutic treatment involving N-desmethylclozapine polymorphic forms.
    Type: Application
    Filed: March 31, 2005
    Publication date: December 22, 2005
    Inventors: Bo-Ragnar Tolf, Mikkel Thygesen, Fritz Blatter, Jörg Berghausen