Abstract: The present invention relates to a hand tool, comprising a tool member, of a first material, an elongated shaft, of a second material and a connecting member, of a third material comprising plastic. The elongated shaft further comprises a handle portion in a first end and an insert portion in a second end. The hand tool further comprises a sealing ring arranged to surround the insert portion to prevent leakage of the third material during manufacturing. A manufacturing method for such a hand tool is also presented, said method comprising arranging a sealing ring around an insert portion, arranging the insert portion and a tool member in a mold, injecting material comprising plastic in a cavity space so as to form a connecting member and removing the hand tool from the mold.

Abstract: The invention relates to sulphonamide derivatives of formula (I), where RC is optionally substituted 4-6-membered heterocyclic ring containing one or more N atoms, or RC forms together with the phenyl ring to which it is attached a benzodioxolyl group, or RC is —NR1R2, RA is a group having the formula RB is hydrogen or alkyl. The invention also relates to the use of derivatives of formula (I) as inhibitors for collagen receptor integrins and a process for preparing sulphonamides of formula (I).