Abstract: The present invention relates to compounds of formula (I) and (II) and pharmaceutically acceptable salts thereof. The compounds of formula (I) or (II) possess utility as cytochrome P450 monooxygenase 11A1 (CYP11A1) inhibitors. The compounds are useful as medicaments in the treatment of steroid receptor, particularly androgen receptor, dependent diseases and conditions, such as prostate cancer.

Abstract: The present disclosure relates to an improved process for the preparation of isochroman structured alpha2A adrenoceptor agonist, namely 2-(5-methoxyisochroman-1-yl)-4,5-dihydro-1H-imidazole of formula (I) and a pharmaceutically acceptable salts thereof, such as 2-(5-methoxyisochroman-1-yl)-4,5-dihydro-1H-imidazole hydrogensulfate of formula (Ia), and to a novel intermediate compound used in the process, namely N-(2-aminoethyl)-5-methoxyisochroman-1-carboxamide monohydrate of formula (V). Alpha2A agonists are useful in the treatment of anxiety, and for use as a sedative or analgesic agent, and other diseases where alpha2A agonism is desired.

Abstract: Compounds of formula (I) wherein R1, R2, R3, R4, R5, R23, R24, L, A and B are as defined in claim 1, or pharmaceutically acceptable salts thereof are disclosed. The compounds of formula (I) possess utility as cytochrome P450 monooxygenase 11A1 (CYP11A1) inhibitors. The compounds are useful as medicaments in the treatment of steroid receptor, particularly androgen receptor, dependent diseases and conditions, such as prostate cancer.

Abstract: Compounds of formula (I) wherein R1, R2, R3, R4, R5, R23, R24, L, A and B are as defined in claim 1, or pharmaceutically acceptable salts thereof are disclosed. The compounds of formula (I) possess utility as cytochrome P450 monooxygenase 11A1 (CYP11A1) inhibitors. The compounds are useful as medicaments in the treatment of steroid receptor, particularly androgen receptor, dependent diseases and conditions, such as prostate cancer.

Abstract: The present disclosure relates to an improved process for the preparation of isochroman structured alpha2A adrenoceptor agonist, namely 2-(5-methoxyisochroman-1-yl)-4,5-dihydro-1H-imidazole of formula (I) and a pharmaceutically acceptable salts thereof, such as 2-(5-methoxyisochroman-1-yl)-4,5-dihydro-1H-imidazole hydrogensulfate of formula (Ia), and to a novel intermediate compound used in the process, namely N-(2-aminoethyl)-5-methoxyisochroman-1-carboxamide monohydrate of formula (V). Alpha2A agonists are useful in the treatment of anxiety, and for use as a sedative or analgesic agent, and other diseases where alpha2A agonism is desired.

Abstract: Compounds of formula (I) wherein R1, R2, R3, R4, R5, R23, R24, L, A and B are as defined in claim 1, or pharmaceutically acceptable salts thereof are disclosed. The compounds of formula (I) possess utility as cytochrome P450 monooxygenase 11A1 (CYP11A1) inhibitors. The compounds are useful as medicaments in the treatment of steroid receptor, particularly androgen receptor, dependent diseases and conditions, such as prostate cancer.

Abstract: Compounds of formula (I) wherein R1, R2, R3, R4, R5, R23, R24, L, A and B are as defined in claim 1, or pharmaceutically acceptable salts thereof are disclosed. The compounds of formula (I) possess utility as cytochrome P450 monooxygenase 11A1 (CYP11A1) inhibitors. The compounds are useful as medicaments in the treatment of steroid receptor, particularly androgen receptor, dependent diseases and conditions, such as prostate cancer.

Abstract: Compounds of formula (I) wherein R1, R2, R3, R4, R5, R23, R24, L, A and B are as defined in claim 1, or pharmaceutically acceptable salts thereof are disclosed. The compounds of formula (I) possess utility as cytochrome P450 monooxygenase 11A1 (CYP11A1) inhibitors. The compounds are useful as medicaments in the treatment of steroid receptor, particularly androgen receptor, dependent diseases and conditions, such as prostate cancer.

Abstract: A mining vehicle including a movable carrier, at least one boom having a plurality of boom joints, several boom actuators for moving the boom in different positions, at least one mining work device being arranged at a distal portion of the boom, and at least one control unit for controlling the position of at least one of the boom and the mining work device. The mining vehicle further including observing device for obtaining information indicative of a position of at least one of the boom and the mining work device in which collision to an obstacle can be avoided. The control unit is configured to control the position of at least one of the boom and the mining work device in response to the obtained information to avoid hitting the obstacle when the mining vehicle moves.

Abstract: A mining vehicle including a movable carrier, at least one boom having a plurality of boom joints, several boom actuators for moving the boom in different positions, at least one mining work device being arranged at a distal portion of the boom, and at least one control unit for controlling the position of at least one of the boom and the mining work device. The mining vehicle further including observing means for obtaining information indicative of a position of at least one of the boom and the mining work device in which collision to an obstacle can be avoided. The control unit is configured to control the position of at least one of the boom and the mining work device in response to the obtained information to avoid hitting the obstacle when the mining vehicle moves.

Abstract: Compounds of formula (I), wherein X and R1-R6, are as defined in the claims, exhibit alpha2 agonistic activity and thus are useful as alpha2 agonists, especially as alpha2A agonists. Methods of use of said compounds are also provided.

Abstract: Compounds of formula (I), wherein X and R1-R6, are as defined in the claims, exhibit alpha2 agonistic activity and thus are useful as alpha2 agonists, especially as alpha2A agonists. Methods of use of said compounds are also provided.

Abstract: This invention relates to method for presenting at least a part of a page, comprising at least partially dividing at least one page into a plurality of areas, presenting said plurality of areas in a first representation, making at least one area of said plurality of areas an active area, and in response to a user operation on said at least one active area, presenting at least one of said at least one active areas in a second representation. Said at least one page may be a Hypertext Markup Language HTML page, or a page of a text document, and said display may be integrated in a portable electronic device. The invention further relates to a device, a system, a computer program and a computer program product.

Abstract: The invention relates to network connection management, wherein user confirmations are queried for implementing operations requiring a network connection. According to the invention the user confirmation are queried variantly depending on the initiator of the operation. The invention relates to a devices for browsing the network and to a computer program product.

Abstract: The invention relates to a method and an apparatus of requesting a service from a communications network. In the method the following steps are to performed: generating an objective statement in a user equipment; communicating the objective statement from the user equipment to a mediator unit; comparing the objective statement to a list of objective statements in the mediator unit; establishing the service based at least partly on the comparison; and providing the service to the user of the user equipment.

Abstract: The invention relates to a method, a device, a computer program product, a browser and a network element for improved portrayal of navigation objects (1-1 . . . 1-6), wherein at least two navigation objects (1-1 . . . 1-6) are combined into one combined navigation object (4), wherein said combined navigation object (4) is presented, and wherein said at least two navigation objects (1-1 . . . 1-6) are presented, if said combined navigation object (4) is selected.

Abstract: In the method for displaying a web page, a web page received from a server and comprising a frameset is displayed in the browser window of a terminal in such a manner that the frameset is converted into a different format. In the method, the frameset is converted into a table (T), in which case each frame (F1, F2) is converted into a corresponding cell (TD1, TD2) of the table (T). The formed table (T) is then displayed in said browser window (D2). The invention also relates to a conversion method, as well as to a converting unit and a computer software for implementing this conversion method. In addition, the invention relates to a system, as well as to a terminal (MS).

Abstract: A method for displaying information in a device (1), which information is stored as a document with interpreting instructions for displaying the information. The interpreting instructions are interpreted, and on the basis of the interpretation, the information is converted to information to be displayed on the display of the device. In connection with the conversion of the document, it is examined if the document can be displayed without optimization on the display (2) of the device, wherein if, on the basis of the examination, it is detected that the displaying of the document requires optimization, the document is optimized; in other cases, the document is displayed in unoptimized format. The invention also relates to a system and a device (1) applying the method.

Abstract: The invention relates to an optimization of digital content being presented on the display. In a method for optimizing content, the content is analyzed and at least one sequence element is determined. According to this sequence element, said content is portioned into at least two portions, whereby an operation for at least one portion is performed. Also, a control element is provided for at least one other portion.

Abstract: The invention relates to a method and an apparatus of requesting a service from a communications network. In the method the following steps are to performed: generating an objective statement in a user equipment; communicating the objective statement from the user equipment to a mediator unit; comparing the objective statement to a list of objective statements in the mediator unit; establishing the service based at least partly on the comparison; and providing the service to the user of the user equipment.