Patents by Inventor Mikko Sairanen
Mikko Sairanen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220244249Abstract: A microplate comprising: a plurality of wells arranged in a two-dimensional array, each of the wells comprising: a bottom surface, sidewalls extending from the bottom surface to form an open top; and at least two subwells in the bottom surface, the at least two subwells having sidewalls that extend below the bottom surface of the well, wherein each of the at least two subwells comprises a capture binding agent that is configured to bind to a target analyte, if present, in a sample. A sample is added to the well such that the sample fluidically contacts each of the at least two subwells such that a target analyte, if present, binds to the capture binding agent in one or more of the at least two subwells, wherein a labeled conjugate (e.g., an upconverting nanoparticle (UCNP) labeled conjugate) in the sample binds with the target analyte, if present. A label (e.g.Type: ApplicationFiled: February 1, 2022Publication date: August 4, 2022Inventors: Teemu KORPIMÄKI, Mikko SAIRANEN, Ville VEIKKOLAINEN
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Publication number: 20220244277Abstract: A lateral flow test strip reader for reading an output of a lateral flow assay to determine a presence or absence of a target in a sample includes: a housing having a lateral flow test strip receptacle for receiving a lateral flow test strip therein, the lateral flow test strip receptacle defining a test region and a control region for a lateral flow test strip; a light source that generates an excitation light beam; at least one lens for optically expanding the excitation light beam in a direction across the test region and the control region such that the excitation light beam is configured to simultaneously impinge and excite both the test region and the control region; and an optical detector configured to simultaneously detect an image comprising emission signals from the test region and the control region, wherein the detected emission signals indicate a presence or absence of a target in the sample.Type: ApplicationFiled: February 1, 2022Publication date: August 4, 2022Inventors: Joona-Pekko KAKKO, Henna PÄKKILÄ, Teemu KORPIMÄKI, Mikko SAIRANEN, Ville VEIKKOLAINEN
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Patent number: 11255861Abstract: The present invention relates to a method for determining risk of preterm birth (PTB) in a pregnant individual. The method comprises measuring in a biological sample obtained from the pregnant individual, levels of biomarkers AFP and free hCGbeta, and at least one biomarker selected from FSTL3, sTNFR1, PIGF2, Activin A, uE3 and sP-selectin and optionally cervical length; or levels of biomarkers AFP and free hCGbeta and cervical length, and determining a relative risk of the pregnant individual developing PTB. The invention relates also to a kit, apparatus and system for predicting risk of PTB.Type: GrantFiled: August 27, 2019Date of Patent: February 22, 2022Assignee: Wallac OyInventors: Pertti Hurskainen, Heikki Kouru, Mikko Sairanen, Tarja Ahola, Teemu Korpimäki
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Patent number: 11162955Abstract: A method for predicting risk of gestational diabetes mellitus (GDM) in a pregnant individual includes measuring one or more biochemical markers in a blood sample obtained from the pregnant individual to determine one or more biomarker levels, where the one or more measured biochemical markers includes at least one of PAI-2 and sTNFR1, identifying, for each of the one or more measured biochemical markers, a difference between the measured biomarker level and a corresponding predetermined control level, and, responsive to the identifying, determining a prediction corresponding to a relative risk of the pregnant individual having or developing GDM.Type: GrantFiled: September 28, 2018Date of Patent: November 2, 2021Assignee: Wallac OyInventors: Pertti Hurskainen, Teemu Korpimäki, Heikki Kouru, Mikko Sairanen
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Patent number: 10656163Abstract: The present description relates to a method for determining the risk of a pregnant woman with chronic hypertension developing early or late onset pre-eclampsia. The present description provides methods useful for determining risk that a pregnant individual with chronic hypertension will develop an early pre-eclampsia or late pre-eclampsia. Useful combination of biochemical markers including PlGF and sP-Selectin and related clinical population studies are described herein.Type: GrantFiled: September 1, 2015Date of Patent: May 19, 2020Assignee: Wallac OyInventors: Tarja Ahola, Heikki Kouru, Mikko Sairanen
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Publication number: 20200033354Abstract: The present invention relates to a method for determining risk of preterm birth (PTB) in a pregnant individual. The method comprises measuring in a biological sample obtained from the pregnant individual, levels of biomarkers AFP and free hCGbeta, and at least one biomarker selected from FSTL3, sTNFR1, PIGF2, Activin A, uE3 and sP-selectin and optionally cervical length; or levels of biomarkers AFP and free hCGbeta and cervical length, and determining a relative risk of the pregnant individual developing PTB. The invention relates also to a kit, apparatus and system for predicting risk of PTB.Type: ApplicationFiled: August 27, 2019Publication date: January 30, 2020Applicant: Wallac OyInventors: Pertti HURSKAINEN, Heikki KOURU, Mikko SAIRANEN, Tarja AHOLA, Teemu KORPIMÄKI
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Patent number: 10444247Abstract: The present invention relates to a method for determining risk of preterm birth (PTB) in a pregnant individual. The method comprises measuring in a biological sample obtained from the pregnant individual, levels of biomarkers AFP and free hCGbeta, and at least one biomarker selected from FSTL3, sTNR1, P1GF2, Activin A, Ue3 and sP-selectin and optionally cervical length; or levels of biomarkers AFP and free hCGbeta and cervical length, and determining a relative risk of the pregnant individual developing PTB. The invention relates also to a kit, apparatus and system for predicting risk of PTB.Type: GrantFiled: September 11, 2015Date of Patent: October 15, 2019Assignee: Wallac OyInventors: Pertti Hurskainen, Heikki Kouru, Mikko Sairanen, Tarja Ahola, Teemu Korpimäki
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Publication number: 20190137508Abstract: A method for predicting risk of gestational diabetes mellitus (GDM) in a pregnant individual includes measuring one or more biochemical markers in a blood sample obtained from the pregnant individual to determine one or more biomarker levels, where the one or more measured biochemical markers includes at least one of PAI-2 and sTNFR1, identifying, for each of the one or more measured biochemical markers, a difference between the measured biomarker level and a corresponding predetermined control level, and, responsive to the identifying, determining a prediction corresponding to a relative risk of the pregnant individual having or developing GDM.Type: ApplicationFiled: September 28, 2018Publication date: May 9, 2019Inventors: Pertti Hurskainen, Teemu Korpimäki, Heikki Kouru, Mikko Sairanen
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Patent number: 10119978Abstract: A method for predicting risk of gestational diabetes mellitus (GDM) in a pregnant individual includes measuring one or more biochemical markers in a blood sample obtained from the pregnant individual to determine one or more biomarker levels, where the one or more measured biochemical markers includes at least one of PAI-2 and sTNFR1, identifying, for each of the one or more measured biochemical markers, a difference between the measured biomarker level and a corresponding predetermined control level, and, responsive to the identifying, determining a prediction corresponding to a relative risk of the pregnant individual having or developing GDM.Type: GrantFiled: March 15, 2013Date of Patent: November 6, 2018Assignee: WALLAC OYInventors: Pertti Hurskainen, Teemu Korpimäki, Heikki Kouru, Mikko Sairanen
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Publication number: 20180156815Abstract: A method for predicting risk of gestational diabetes mellitus (GDM) in a pregnant individual includes measuring one or more biochemical markers in a blood sample obtained from the pregnant individual to determine one or more biomarker levels, where the one or more measured biochemical markers includes at least one of PAI-2 and sTNFR1, identifying, for each of the one or more measured biochemical markers, a difference between the measured biomarker level and a corresponding predetermined control level, and, responsive to the identifying, determining a prediction corresponding to a relative risk of the pregnant individual having or developing GDM.Type: ApplicationFiled: February 1, 2018Publication date: June 7, 2018Inventors: Pertti Hurskainen, Teemu Korpimäki, Heikki Kouru, Mikko Sairanen
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Publication number: 20170285041Abstract: The present description relates to a method for determining the risk of a pregnant woman with chronic hypertension developing early or late onset pre-eclampsia. The present description provides methods useful for determining risk that a pregnant individual with chronic hypertension will develop an early pre-eclampsia or late pre-eclampsia. Useful combination of biochemical markers including PlGF and sP-Selectin and related clinical population studies are described herein.Type: ApplicationFiled: September 1, 2015Publication date: October 5, 2017Applicant: Wallac OyInventors: Tarja Ahola, Heikki Kouru, Mikko Sairanen
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Publication number: 20170261511Abstract: The present invention relates to a method for determining risk of preterm birth (PTB) in a pregnant individual. The method comprises measuring in a biological sample obtained from the pregnant individual, levels of biomarkers AFP and free hCG-beta, and at least one biomarker selected from FSTL3, sTNR1, P1GF2, Activin A, Ue3 and sP-selectin and optionally cervical length; or levels of biomarkers AFP and free hCGbeta and cervical length, and determining a relative risk of the pregnant individual developing PTB. The invention relates also to a kit, apparatus and system for predicting risk of PTB.Type: ApplicationFiled: September 11, 2015Publication date: September 14, 2017Applicant: Wallac OyInventors: Pertti HURSKAINEN, Heikki KOURU, Mikko SAIRANEN, Tarja AHOLA, Teemu KORPIMAKI
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Publication number: 20160327563Abstract: A method for predicting risk of pre-eclampsia in a pregnant individual includes measuring one or more biochemical markers including an RBP4 biochemical marker in a blood sample obtained from the pregnant individual to determine one or more biomarker levels including an RBP4 biomarker level, identifying, for each of the one or more measured biochemical markers, a difference between the measured biomarker level and a corresponding predetermined control level, and, responsive to the identifying, determining a prediction corresponding to a relative risk of the pregnant individual having or developing pre-eclampsia.Type: ApplicationFiled: April 15, 2016Publication date: November 10, 2016Inventors: Pertti Hurskainen, Teemu Korpimäki, Heikki Kouru, Mikko Sairanen
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Publication number: 20140273025Abstract: A method for predicting risk of pre-eclampsia in a pregnant individual includes measuring one or more biochemical markers including an RBP4 biochemical marker in a blood sample obtained from the pregnant individual to determine one or more biomarker levels including an RBP4 biomarker level, identifying, for each of the one or more measured biochemical markers, a difference between the measured biomarker level and a corresponding predetermined control level, and, responsive to the identifying, determining a prediction corresponding to a relative risk of the pregnant individual having or developing pre-eclampsia.Type: ApplicationFiled: March 15, 2013Publication date: September 18, 2014Applicant: Wallac OyInventors: Pertti Hurskainen, Teemu Korpimäki, Heikki Kouru, Mikko Sairanen
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Publication number: 20140273024Abstract: A method for predicting risk of gestational diabetes mellitus (GDM) in a pregnant individual includes measuring one or more biochemical markers in a blood sample obtained from the pregnant individual to determine one or more biomarker levels, where the one or more measured biochemical markers includes at least one of PAI-2 and sTNFR1, identifying, for each of the one or more measured biochemical markers, a difference between the measured biomarker level and a corresponding predetermined control level, and, responsive to the identifying, determining a prediction corresponding to a relative risk of the pregnant individual having or developing GDM.Type: ApplicationFiled: March 15, 2013Publication date: September 18, 2014Applicant: Wallac OyInventors: Pertti Hurskainen, Teemu Korpimäki, Heikki Kouru, Mikko Sairanen