Patents by Inventor Miklos Bodanszky

Miklos Bodanszky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polypeptides and methods of preparation
    Patent number: 4237046
    Abstract: There are disclosed active fragments of vasoactive peptides and methods of preparation. The active fragments comprise the following amino acid sequences:(a) X-MET-ALA-VAL-X.sub.1(b) X-MET-ALA-VAL-LYS-X.sub.1(c) X-MET-ALA-VAL-LYS-LYS-TYR-LEU-ASN-SER-Y-LEU-Z-X.sub.1wherein X is hydrogen, glutamyl, or pyroglutamyl, X.sub.1 is OH or NH.sub.2 ; Y is ILE or VAL; and Z is ASN or THR.
    Type: Grant
    Filed: April 27, 1979
    Date of Patent: December 2, 1980
    Inventor: Miklos Bodanszky
  • Solid phase synthesis of peptides
    Patent number: 4028315
    Abstract: A process for bonding an amino acid to an insoluble hydroxymethyl polymer by esterifying the C-terminal carboxyl group of an N-terminal protected amino acid with the hydroxyl group of an insoluble hydroxymethyl polymer. The esterifying takes place at about room temperature in the presence of a condensing agent. The insoluble hydroxymethyl polymer is a hydroxymethylated copolymer of styrene and divinylbenzene, hydroxymethylcellulose, hydroxymethylated sulfonated polystyrene or polyvinyl alcohol. The condensing agent is dicyclohexylcarbodiimide, carbonyldiimidazole, thionyl chloride, phosphorous oxychloride or ethoxyacetylene. Peptides can be formed by bonding one or more amino acids to the amino acid bonded to the insoluble hydroxymethyl polymer.
    Type: Grant
    Filed: February 20, 1973
    Date of Patent: June 7, 1977
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miklos Bodanszky, John Timothy Sheehan
  • Amino acid derivatives
    Patent number: 3957760
    Abstract: New lactone intermediates useful in the synthesis of peptides are prepared by reacting an .alpha.-amino acid with an active carbonyl compound which forms a Schiff's base. The latter is treated with a condensing agent so that cyclization occurs and a lactone is formed from which a peptide may be produced by reaction with an amino acid ester and removal of the protecting groups.
    Type: Grant
    Filed: April 9, 1973
    Date of Patent: May 18, 1976
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Miklos Bodanszky
  • Process and apparatus for the synthesis of peptides not linked to polymers
    Patent number: 3944538
    Abstract: In situ process for synthesizing peptides not linked to polymers. The peptide derivatives remain in the same reaction vessel throughout the chain-lengthening procedure. Preferred apparatus for performing the process comprises means for mixing, evaporation and centrifugation.
    Type: Grant
    Filed: October 2, 1973
    Date of Patent: March 16, 1976
    Inventor: Miklos Bodanszky