Patents by Inventor Miklos Jarai

Miklos Jarai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of vancomycin
    Patent number: 5223413
    Abstract: The invention relates to a process for preparation of the vancomycin antibiotic in a microbiological way by aerobic fermentation, by using a strain belonging to the Micropolyspora species in a culture-medium containing assimilable carbon and nitrogen sources as well as mineral salts. According to the invention as microorganisms the aminoglycoside-resistant NCAIM 001092 and NCAIM 001093 mutants of the strain belonging to the Micropolyspora orientalis species are used. Nitrates are suitable mineral salts in the fermentation. Soy flour, glycerol, calcium gluconate, starch are useful carbon sources. The fermentation is carried out preferably at a temperature of 29.degree.-30.degree. C. The vancomycin antibiotic produced in the fermentation is separated by using reverse osmosis and ultrafiltration following ion-exchange chromatography.
    Type: Grant
    Filed: September 26, 1991
    Date of Patent: June 29, 1993
    Assignee: Biochin Biotechnologial Leanyvallalat
    Inventors: Mariann Nagy, Miklos Jarai, Istvan Financsek, Ilona Varga, Geza Kocsis, Viola Muri, Andrasi Andras, Laszlo Kegl, Gabriella Zlatos, Marta Szoke nee Zlatos, Endre Kollar, A/ gnes Udvardy, Mihaly Garamvolgyi
  • Process for the preparation of high-purity gamma- and alpha-cyclodextrins
    Patent number: 4835105
    Abstract: The invention relates to a process for the preparation of high-purity gamma- and alpha-cyclodextrin starting from a starch substrate of low reducing capacity, partially hydrolysed with alpha-amylase. According to the invention a starch substrate of low reducing capacity partially hydrolysed with alpha-amylase is converted with cyclodextrin glucosyl transferase, after the addition of an aliphatic ketone of the formula R.sub.1 COR.sub.2, in which R.sub.1 and R.sub.2 stand for a straight or branched chained alkyl group having from 1 to 6 carbon atoms, and/or a phenol derivative of the formula R.sub.3 R.sub.4 PheOH, wherein R.sub.3 and R.sub.4 are hydrogen, alkyl having from 1 to 4 carbon atoms, or R.sub.3 and R.sub.4 together form phenyl group, Phe stand for phenyl group, OH is hydroxyl and/or a benzene derivative of the formula R.sub.5 R.sub.6 Phe, wherein R.sub.5 and R.sub.6 are hydrogen, alkyl having from 1 to 4 carbon atoms, or R.sub.5 and R.sub.
    Type: Grant
    Filed: July 9, 1987
    Date of Patent: May 30, 1989
    Assignee: Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.
    Inventors: Gabor Seres, Miklos Jarai, Sandor Piukovich, Maria Szigetvari nee Gabanyi, Jozsef Szejtli
  • Micromonospora culture
    Patent number: 4371622
    Abstract: Micromonospora danubiensis, a new species, having the capability of producing sisomicin.
    Type: Grant
    Filed: January 30, 1980
    Date of Patent: February 1, 1983
    Assignee: CHINOIN Gyogyszer es Vegyeszeti Termekek Gyara R.T.
    Inventors: Miklos Jarai, Sandor Piukovich, Sandor Istvan, Istvan Gado, Valeria Szell, Istvan Barta
  • Method for the production of sisomicin
    Patent number: 4369251
    Abstract: Sisomicin is produced by culturing Micromonospora danubienis.
    Type: Grant
    Filed: December 8, 1980
    Date of Patent: January 18, 1983
    Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara R.T.
    Inventors: Miklos Jarai, Sandor Piukovich, Sandor Istvan, Istvan Gado, Valeria Szell, Istvan Barta
  • Method for the preparation of antibiotic sisomicin
    Patent number: 4365020
    Abstract: A process of producing sisomycin by cultivating a new species of Micromonospora.
    Type: Grant
    Filed: December 8, 1980
    Date of Patent: December 21, 1982
    Assignee: CHINOIN Gyogyszer es Vegyeszeti Termekek Gyara R.T.
    Inventors: Istvan Gado, Antonia Jekkel nee Bokany, Gyorgy Szvoboda, Miklos Jarai, Sandor Piukovich, Sandor Istvan
  • Micromonospora culture
    Patent number: 4363876
    Abstract: A culture of Micromonospora rosea capable of producing the antibiotic sisomicin.
    Type: Grant
    Filed: January 30, 1980
    Date of Patent: December 14, 1982
    Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara R.T.
    Inventors: Istvan Gado, Antonia Jekkel nee Bokany, Gy uml/o/ rgy Szvoboda, Miklos Jarai, Sandor Piukovich, Sandor Istvan