Patents by Inventor Miklos Low

Miklos Low has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sulphated vinyl polymer in composition for treating retroviral infections
    Patent number: 5292505
    Abstract: Sulphated vinyl polymers such as sulphated polyvinylalcohol, sulphated copolymers of (meth)acrylic acid and vinylalcohol, and pharmaceutically acceptable salts thereof, have an antiviral effect against human immunodeficiency virus and may therefore be used as a therapeutic agent for treating retrovirus infections like AIDS and AIDS-related diseases. Their antiviral activity is apparently based on inhibition of virus adsorption; their inhibitory effect on giant cell formation is stronger than that of dextran sulphate.
    Type: Grant
    Filed: January 15, 1992
    Date of Patent: March 8, 1994
    Assignees: Stichting Rega VZW, Richter Gedeon Vegyeszeti Gyar RT
    Inventors: Masanori Baba, Erik D. A. De Clercq, Sandor Gorog, Miklos Low, Miklos Nagy, Sandorne Gyorgyi
  • Sulphated vinyl polymers in compositions for treating retroviral infections
    Patent number: 5152978
    Abstract: Sulphated vinyl polymers such as sulphated polyvinylalcohol, sulphated copolymers of (meth)acrylic acid and vinylalcohol, and pharmaceutically acceptable salts thereof, have an antiviral effect against human immunodeficiency virus and may therefore be used as a therapeutic agent for treating retrovirus infections like AIDS and AIDS-related diseases. Their antiviral activity is apparently based on inhibition of virus adsorption; their inhibitory effect on giant cell formation is stronger than that of dextran sulphate.
    Type: Grant
    Filed: February 23, 1989
    Date of Patent: October 6, 1992
    Assignees: Stichting Rega VZW, Richter Gedeon Vegyeszeti Gyar R.T.
    Inventors: Masanori Baba, Erik D. A. De Clercq, Sandor Gorog, Miklos Low, Miklos Nagy, Sandorne Gyorgyi
  • Pharmaceutically active copolymers, process for their preparation and pharmaceutical compositions containing them
    Patent number: 4530964
    Abstract: The invention relates to new, pharmaceutically active copolymers with heparin-like activity, pharmaceutically acceptable salts thereof and a process for their preparation.
    Type: Grant
    Filed: March 24, 1983
    Date of Patent: July 23, 1985
    Assignee: Richter Gedeon Vegyeszeti Gyar R.T.
    Inventors: Raymund Machovich, Miklos Nagy, Judit Gyorgyi nee Edelenyi, Istvan Horvath, Miklos Low, Katalin Csomor, Egon Karpati, Laszlo Szporny, Lajos Kisfaludy
  • Process for the preparation of the cholecystokinin-pancreozymin octapeptide amide sulfate ester
    Patent number: 4102878
    Abstract: A process for the preparation of L-aspartyl-(O-sulfato-L-tyrosyl)-L-methionyl-glycyl-L-tryptophyl-L-methion yl-L-aspartyl-L-phenylalanine amide, which comprises treating the protected octapeptide amide of the general formula (II) ##STR1## wherein X is BOC, Cbz or Ddz,Y is O.sup.t Bu, OBzl or OH andW is O.sup.t Bu, OBzl or OH,in the presence of an ether with an excess of the complex compound of sulfur trioxide and a tertiary amine containing at least one alkyl group, converting the obtained sulfate ester of the protected octapeptide amide into an alkali metal salt and simultaneously removing the formyl group from the tryptophan unit by reacting the sulfate ester with an alkali metal hydroxide, and then splitting off the remaining protective groups by acidolysis.
    Type: Grant
    Filed: April 28, 1977
    Date of Patent: July 25, 1978
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Botond Penke, Lajos Balaspiri, Peter Pallai, Kalman Kovacs, Vince Varro, Janos Lonovics, Laszlo Varga, Gyorgy Dobo, Geza Ivanyi, Lajos Kovacs, Miklos Low, Judit Low, nee Kaloczy
  • Process for the preparation of biologically active polypeptides containing aspartyl group
    Patent number: 3953415
    Abstract: The invention relates to the preparation of biologically active polypeptides containing the aspartyl group, particularly an aspartyl-glycine moiety, using the active-ester technique.According to the method of the invention, human adrenocorticotropic hormone and its fragments characteristic to the individual species, as well as the blocked derivatives of such compounds are prepared by the pentafluorophenol method, i.e., the carboxy group of the acylating component is activated by converting it into pentafluorophenyl ester in the coupling reaction carried out with blocked peptides containing the aspartyl group or an aspartylglycine moiety. The acylation is carried out preferably using equimolar quantities of the respective reactants. The free peptides obtained after removing the blocking groups can be converted into their acid addition salts or pharmaceutically acceptable complexes or condensates.Human adrenocorticotropic hormone and its derivatives are valuable substances of therapeutical activity.
    Type: Grant
    Filed: May 14, 1973
    Date of Patent: April 27, 1976
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt
    Inventors: Lajos Kisfaludy, Miklos Low, Istvan Schon, Tamas Szirtes, Maria Sz. Sarkozi, Sandor Bajusz, Andrae Turan, Rosa Beks, Attila Juhasz, Laszlo Graf, Kalman Medzihradszky, Laszlo Szporny