Patents by Inventor Milan DEJMEK

Milan DEJMEK has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 3?3? CYCLIC DINUCLEOTIDES WITH AN ALKENYLENE
    Publication number: 20230303613
    Abstract: The present disclosure describes 3?3? cyclic phosphonate dinucleotides of general formula (J), their pharmaceutically acceptable salts, their pharmaceutical composition and combinations of substances and other medicaments or pharmaceuticals. The disclosure also describes the use of compounds for the treatment or prevention of diseases or conditions modifiable by STING protein modulation, such as cancer or viral, allergic and inflammatory diseases. These substances can be used as adjuvants in vaccines.
    Type: Application
    Filed: April 15, 2021
    Publication date: September 28, 2023
    Inventors: Gabriel BIRKUS, Milan DEJMEK, Radim NENCKA, Tomas OTAVA, Michal SALA, Ondrej PAV
  • 3?3?-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator
    Patent number: 11766447
    Abstract: The present disclosure relates to 3?3?-cyclic dinucleotides having a carbocyclic nucleotide and derivatives that can modulate the activity of the STING adaptor protein.
    Type: Grant
    Filed: March 4, 2020
    Date of Patent: September 26, 2023
    Assignee: INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.
    Inventors: Gabriel Birkus, Petra Brehova, Milan Dejmek, Radim Nencka, Ondrej Pav, Michal Sala
  • Quinazoline Compounds
    Publication number: 20230043136
    Abstract: Described herein are compounds of Formula (I) and tautomers and pharmaceutical salts thereof, compositions and formulations containing such compounds, and methods of using and making such compounds.
    Type: Application
    Filed: March 9, 2022
    Publication date: February 9, 2023
    Inventors: Ondrej Baszczynski, Milan Dejmek, Yunfeng Eric Hu, Petr Jansa, Eric Lansdon, Richard L. Mackman, Petr Simon
  • 3'3'-CYCLIC DINUCLEOTIDE ANALOGUE COMPRISING A CYCLOPENTANYL MODIFIED NUCLEOTIDE AS STING MODULATOR
    Publication number: 20220160746
    Abstract: The present disclosure relates to 3?3?-cyclic dinucleotides having a carbocyclic nucleotide and derivatives that can modulate the activity of the STING adaptor protein.
    Type: Application
    Filed: March 4, 2020
    Publication date: May 26, 2022
    Applicant: INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I
    Inventors: Gabriel BIRKUS, Petra BREHOVA, Milan DEJMEK, Radim NENCKA, Ondrej PAV, Michal SALA
  • Quinazoline compounds
    Patent number: 11304948
    Abstract: Described herein are compounds of Formula (I) and tautomers and pharmaceutical salts thereof, compositions and formulations containing such compounds, and methods of using and making such compounds.
    Type: Grant
    Filed: December 18, 2019
    Date of Patent: April 19, 2022
    Assignees: Gilead Sciences, Inc.
    Inventors: Ondrej Baszczynski, Milan Dejmek, Yunfeng Eric Hu, Petr Jansa, Eric Lansdon, Richard L. Mackman, Petr Simon
  • Quinazoline Compounds
    Publication number: 20200360383
    Abstract: Described herein are compounds of Formula (I) and tautomers and pharmaceutical salts thereof, compositions and formulations containing such compounds, and methods of using and making such compounds.
    Type: Application
    Filed: December 18, 2019
    Publication date: November 19, 2020
    Inventors: Ondrej Baszczynski, Milan Dejmek, Yunfeng Eric Hu, Petr Jansa, Eric Lansdon, Richard L. Mackman, Petr Simon
  • Quinazoline compounds
    Patent number: 10548898
    Abstract: Described herein are compounds of Formula (I) and tautomers and pharmaceutical salts thereof, compositions and formulations containing such compounds, and methods of using and making such compounds.
    Type: Grant
    Filed: January 4, 2019
    Date of Patent: February 4, 2020
    Assignees: Gilead Sciences Inc., Institute of Organic Chemistry and Biochemistry of the AS CR, V.V.I.
    Inventors: Ondrej Baszczynski, Milan Dejmek, Yunfeng Eric Hu, Petr Jansa, Eric Lansdon, Richard L. Mackman, Petr Simon
  • 2'3'-CYCLIC DINUCLEOTIDES COMPRISING CARBOCYCLIC NUCLEOTIDE
    Publication number: 20190359645
    Abstract: The present disclosure relates to 2?3?-cyclic dinucleotides comprising a carbocyclic nucleotide and derivatives thereof, that can modulate the activity of the STING adaptor protein.
    Type: Application
    Filed: May 2, 2019
    Publication date: November 28, 2019
    Inventors: Gabriel Birkus, Milan Dejmek, Radim Nencka, Ondrej Pav, Michal Sala
  • Quinazoline Compounds
    Publication number: 20190134035
    Abstract: Described herein are compounds of Formula (I) and tautomers and pharmaceutical salts thereof, compositions and formulations containing such compounds, and methods of using and making such compounds.
    Type: Application
    Filed: January 4, 2019
    Publication date: May 9, 2019
    Inventors: Ondrej Baszczynski, Milan Dejmek, Yunfeng Eric Hu, Petr Jansa, Eric Lansdon, Richard L. Mackman, Petr Simon
  • Quinazoline compounds
    Patent number: 10206926
    Abstract: Described herein are compounds of Formula (I) and tautomers and pharmaceutical salts thereof, compositions and formulations containing such compounds, and methods of using and making such compounds.
    Type: Grant
    Filed: June 27, 2017
    Date of Patent: February 19, 2019
    Assignees: Gilead Sciences, Inc., Institute of Organic Chemistry and Biochemistry of the AS CR, V.V.I.
    Inventors: Ondrej Baszczynski, Milan Dejmek, Yunfeng Eric Hu, Petr Jansa, Eric Lansdon, Richard L. Mackman, Petr Simon
  • Quinazoline Compounds
    Publication number: 20170354656
    Abstract: Described herein are compounds of Formula (I) and tautomers and pharmaceutical salts thereof, compositions and formulations containing such compounds, and methods of using and making such compounds.
    Type: Application
    Filed: June 27, 2017
    Publication date: December 14, 2017
    Inventors: Ondrej Baszczynski, Milan Dejmek, Yunfeng Eric Hu, Petr Jansa, Eric Lansdon, Richard L. Mackman, Petr Simon
  • Quinazoline compounds
    Patent number: 9730936
    Abstract: Described herein are compounds of Formula (I) and tautomers and pharmaceutical salts thereof, compositions and formulations containing such compounds, and methods of using and making such compounds.
    Type: Grant
    Filed: December 23, 2015
    Date of Patent: August 15, 2017
    Assignees: Gilead Sciences, Inc., Institute of Organic Chemistry and Biochemistry of the AS CR, V.V.I.
    Inventors: Ond{hacek over (r)}ej Baszczy{hacek over (n)}ski, Milan Dejmek, Yunfeng Eric Hu, Petr Jansa, Eric Lansdon, Richard L. Mackman, Petr {hacek over (S)}imon
  • QUINAZOLINE COMPOUNDS
    Publication number: 20160250215
    Abstract: Described herein are compounds of Formula (I) and tautomers and pharmaceutical salts thereof, compositions and formulations containing such compounds, and methods of using and making such compounds.
    Type: Application
    Filed: December 23, 2015
    Publication date: September 1, 2016
    Inventors: Ondrej BASZCZYNSKI, Milan DEJMEK, Yunfeng Eric HU, Petr JANSA, Eric LANSDON, Richard L. MACKMAN, Petr SIMON