Patents by Inventor Milan N. Stojanovic

Milan N. Stojanovic has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Real-Time Assays Of Neuro-Humoral Factors To Assess Cardiovascular Stress
    Publication number: 20090004663
    Abstract: The present invention relates to rapid assays for neuro-humoral factors modulated in response to cardiovascular stress and integration of data obtained from such assays to provide profiles of response to cardiovascular stress that can guide therapy.
    Type: Application
    Filed: June 23, 2008
    Publication date: January 1, 2009
    Inventors: Donald W. Landry, Juan Oliver, Milan N. Stojanovic
  • Cross reactive arrays of three-way junction sensors for steroid determination
    Patent number: 7470516
    Abstract: This invention provides analyte sensitive oligonucleotide compositions for detecting and analyzing analytes in solution, including complex solutions using cross reactive arrays of analyte sensitive oligonucleotide compositions.
    Type: Grant
    Filed: October 14, 2005
    Date of Patent: December 30, 2008
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Milan N. Stojanovic, Donald Landry, Dragan B. Nikic
  • Displacement assay for detection of small molecules
    Publication number: 20080286877
    Abstract: Complex of an anti-cocaine aptamer and the dye diethylthiotricarbocyanine behaves as a calorimetric sensor with attenuation in absorbance at 760 nm for cocaine in the concentration range of 2-5000 ?M. Mechanistic studies indicate an intermolecular displacement of the dye as the mechanism of action of the sensor. As the dye is insoluble in buffer, cocaine binding can be detected as displaced dye precipitates and supernatant decolorizes.
    Type: Application
    Filed: April 24, 2008
    Publication date: November 20, 2008
    Inventors: Milan N. Stojanovic, Donald W. Landry
  • Displacement assay for detection of small molecules
    Patent number: 7381531
    Abstract: Complex of an anti-cocaine aptamer and the dye diethylthiotricarbocyanine behaves as a calorimetric sensor with attenuation in absorbance at 760 nm for cocaine in the concentration range of 2-5000 ?M. Mechanistic studies indicate an intermolecular displacement of the dye as the mechanism of action of the sensor. As the dye is insoluble in buffer, cocaine binding can be detected as displaced dye precipitates and supernatant decolorizes.
    Type: Grant
    Filed: May 6, 2005
    Date of Patent: June 3, 2008
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Milan N. Stojanovic, Donald W. Landry
  • Cross reactive arrays of three-way junction sensors for steroid determination
    Publication number: 20040203007
    Abstract: This invention provides analyte sensitive oligonucleotide compositions for detecting and analyzing analytes in solution, including complex solutions using cross reactive arrays of analyte sensitive oligonucleotide compositions.
    Type: Application
    Filed: April 14, 2003
    Publication date: October 14, 2004
    Inventors: Milan N. Stojanovic, Donald Landry, Dragan B. Nikic
  • Oligonucleotide - based logic gates and molecular networks
    Publication number: 20040070426
    Abstract: A set of deoxyribozyme-based logic gates are capable of generating any Boolean function. The gates include basic NOT and AND gates, and the more complex XOR gate. These gates were constructed through modular design that combines molecular beacon stem-loops with hammerhead-type deoxyribozymes. The gates have oligonucleotides as both inputs and output, thereby communication between various computation elements in solution. The operation of these gates is conveniently connected to a fluorescent readout.
    Type: Application
    Filed: February 21, 2003
    Publication date: April 15, 2004
    Inventor: Milan N. Stojanovic
  • Movement of multi-enzymatic nanoassemblies on recognition landscapes
    Publication number: 20040072226
    Abstract: A macromolecular assembly has a body and at least four catalytic leg units having nucleic acids and is adapted to travel across a layer of oligonucleotide fuel substrate molecules by having each leg unit recognize and bind to a fuel substrate, cleave the fuel substrate and search for a new fuel substrate, said leg units alternately binding and cleaving out of phase to keep at least one leg unit bound to a fuel substrate. The fuel molecules may be arranged to provide a gradient, whereby the assembly travels along the gradient.
    Type: Application
    Filed: July 3, 2003
    Publication date: April 15, 2004
    Inventor: Milan N. Stojanovic
  • Movement of multi-enzymatic nanoassemblies on recognition landscapes
    Publication number: 20040005568
    Abstract: A macromolecular assembly has a body and at least four catalytic leg units having nucleic acids and is adapted to travel across a layer of oligonucleotide fuel substrate molecules by having each leg unit recognize and bind to a fuel substrate, cleave the fuel substrate and search for a new fuel substrate, said leg units alternately binding and cleaving out of phase to keep at least one leg unit bound to a fuel substrate. The fuel molecules may be arranged to provide a gradient, whereby the assembly travels along the gradient.
    Type: Application
    Filed: July 3, 2002
    Publication date: January 8, 2004
    Inventor: Milan N. Stojanovic
  • Displacement assay for detection of small molecules
    Publication number: 20030198966
    Abstract: Complex of an anti-cocaine aptamer and the dye diethylthiotricarbocyanine behaves as a colorimetric sensor with attenuation in absorbance at 760 nm for cocaine in the concentration range of 2-5000 &mgr;M. Mechanistic studies indicate an intermolecular displacement of the dye as the mechanism of action of the sensor. As the dye is insoluble in buffer, cocaine binding can be detected as displaced dye precipitates and supernatant decolorizes.
    Type: Application
    Filed: April 19, 2002
    Publication date: October 23, 2003
    Inventors: Milan N. Stojanovic, Donald W. Landry