Abstract: A positive power anterior chamber ocular implant for placement in a phakic eye is disclosed to correct refractive errors caused by hyperopia which includes at least one convex surface and haptics for positioning the lens in the anterior chamber of the eye. Contact between the lens and other anatomic bodies, such as the anatomical lens, the corneal endothelium and iris is avoided, and the haptics avoid contact with the iris.

Abstract: Disclosed are methods and compositions for inhibiting undesirable visual anomalies commonly experienced by individuals who have undergone refractive eye surgery, including photophobia, glare, secondary images and haloing. In particular, the disclosure provides for topically applying an ophthalmic solution to the eye wherein the ophthalmic solution contains a therapeutically effective amount of one or more alpha adrenergic blocking agents, preferably thymoxamine. The disclosure further provides for an ophthalmic solution containing one or more alpha adrenergic blocking agents in a physiologically acceptable carrier, which can be administered to a subject at an effective dose to be therapeutically effective in concentration and rate of release.

Abstract: The invention is directed to a positive power anterior chamber ocular implant for placement in a phakic eye to correct refractive errors caused by hyperopia which includes at least one convex surface and means for positioning the lens in the anterior chamber of an eye, wherein contact between the lens and other anatomic bodies such as the anatomical lens, the corneal endothelium and iris is avoided, and wherein the means for positioning avoids contact with the iris.

Abstract: The present disclosure relates generally to a refractive anterior chamber ocular implant for placement in the anatomic angle of a phakic eye, the implant having an artificial lens or optic with an anterior surface and a posterior surface and having a haptic for engaging and positioning the optic in the anatomic angle, wherein the haptic possesses in an extension pad that extends and tapers in thickness from the haptic in an axial direction. The disclosure is further directed to methods for correcting refractive errors in a patient in need thereof having a phakic eye and an anatomic angle by surgically implanting an angle supported anterior chamber ocular implant having an optic with the desired refractive properties and a haptic having an extension pad that extends and tapers in thickness from the haptic in an axial direction, and anchoring the extension pad into the anatomic angle of the eye.

Abstract: The present disclosure relates generally to a refractive anterior chamber ocular implant for placement in the anatomic angle of a phakic eye, the implant having an artificial lens or optic with an anterior surface and a posterior surface and having a haptic for engaging and positioning the optic in the anatomic angle, wherein the haptic possesses in an extension pad that extends and tapers in thickness from the haptic in an axial direction. The disclosure is further directed to methods for correcting refractive errors in a patient in need thereof having a phakic eye and an anatomic angle by surgically implanting an angle supported anterior chamber ocular implant having an optic with the desired refractive properties and a haptic having an extension pad that extends and tapers in thickness from the haptic in an axial direction, and anchoring the extension pad into the anatomic angle of the eye.

Abstract: The present invention provides a method of modifying surfaces of contact lenses to reduce bacterial, fungal or viral concentration and adherence. The method of the invention comprises the coating of a contact lens surface with a sulfated polysaccharide such as heparin to reduce the concentration of microorganisms, as well as bacterial, fungal or viral adherence. The invention further relates to compositions comprising contact lenses for correcting vision deficiencies of the eye coated with a sulfated polysaccharide such as heparin. Contact lens surfaces as provided in accordance with this invention have a coating of sulfated polysaccharide which reduces the concentration of microorganisms of all types and prevents the adherence of bacteria, fungi or viruses to the lens surface thereby reducing the potential for infection.

Abstract: The disclosure is directed to a positive power anterior chamber ocular implant for placement in a phakic eye to correct refractive errors caused by hyperopia which includes at least one convex surface and means for positioning the lens in the anterior chamber of an eye, wherein contact between the lens and other anatomic bodies such as the anatomical lens, the corneal endothelium and iris is avoided, and wherein the means for positioning avoids contact with the iris.

Abstract: A minus power anterior chamber ocular implant for placement in the anterior chamber of a phakic eye having an anatomic lens in situ comprises a negative artificial refracting lens having at least one concave surface, a surface coating which comprises a compatible sulfated polysaccharide medicament coating, such as heparin, and having a structure which positions the artificial lens in the anterior chamber of the eye to prevent contact between the implant and the anatomic lens. The implant compensates for refractive errors or creates a specific refraction to assist in visual function and has increased biocompatibility in the anterior chamber of the eye, thereby preventing or mitigating detrimental effects typically associated with the implantation of an uncoated refractive anterior chamber implant in the eye.

Abstract: The present invention relates to compositions which maintain the structural integrity of the anterior chamber of the eye during ophthalmologic surgery, thereby protecting the tissues that form and line the anterior segment from potential damage and simultaneously providing sustained delivery of pharmaceuticals, including miotic, mydriatic, or anesthetic agents.

Abstract: The present invention relates to compositions which maintain the structural integrity of the anterior chamber of the eye during ophthalmologic surgery, thereby protecting the tissues that form and line the anterior segment from potential damage and simultaneously providing sustained delivery of a miotic or mydriatic agent. The present invention provides for compositions which comprise a viscoelastic polymer, wherein sustained release of a miotic or mydriatic agent is mediated by ionic interactions, as well as for compositions wherein sustained release of a miotic or mydriatic agent is mediated by microcapsules or copolymer micelles.

Abstract: A minus power anterior chamber ocular implant for placement in the anterior chamber of a phakic eye having an anatomic lens in situ comprises a negative artificial refracting lens having at least one concave surface, a surface coating which comprises a compatible sulfated polysaccharide medicament coating, such as heparin, and having a structure which positions the artificial lens in the anterior chamber of the eye to prevent contact between the implant and the anatomic lens. The implant compensates for refractive errors or creates a specific refraction to assist in visual function and has increased biocompatibility in the anterior chamber of the eye, thereby preventing or mitigating detrimental effects typically associated with the implantation of an uncoated refractive anterior chamber implant in the eye.

Abstract: The present invention relates to compositions which maintain the structural integrity of the anterior chamber of the eye during ophthalmologic surgery, thereby protecting the tissues that form and line the anterior segment from potential damage and simultaneously providing sustained delivery of a miotic or mydriatic agent. The present invention provides for compositions which comprise a viscoelastic polymer, wherein sustained release of a miotic or mydriatic agent is mediated by ionic interactions, as well as for compositions wherein sustained release of a miotic or mydriatic agent is mediated by microcapsules or copolymer micelles.

Abstract: The present invention relates to compositions which maintain the structural integrity of the anterior chamber of the eye during ophthalmologic surgery, thereby protecting the tissues that form and line the anterior segment from potential damage and simultaneously providing sustained delivery of a miotic or mydriatic agent. The present invention provides for compositions which comprise a viscoelastic polymer, wherein sustained release of a miotic or mydriatic agent is mediated by ionic interactions, as well as for compositions wherein sustained release of a miotic or mydriatic agent is mediated by microcapsules or copolymer micelles.

Abstract: A minus power anterior chamber ocular implant for placement in the anterior chamber of a phakic eye having an anatomic lens in situ comprises a negative artificial refracting lens having at least one concave surface, a surface coating which comprises a compatible sulfated polysaccharide medicament coating, such as heparin, and and having a structure which positions having a structure which positions the artificial lens in the anterior chamber of the eye to prevent contact between the implant and the anatomic lens. The implant compensates for refractive errors or creates a specific refraction to assist in visual function and has increased biocompatibility in the anterior chamber of the eye, thereby preventing or mitigating detrimental effects typically associated with the implantation of an uncoated refractive anterior chamber implant in the eye.

Abstract: The present invention relates to compositions which maintain the structural integrity of the anterior chamber of the eye during ophthalmologic surgery, thereby protecting the tissues that form and line the anterior segment from potential damage and simultaneously providing sustained delivery of a miotic or mydriatic agent. The present invention provides for compositions which comprise a viscoelastic polymer, wherein sustained release of a miotic or mydriatic agent is mediated by ionic interactions, as well as for compositions wherein sustained release of a miotic or mydriatic agent is mediated by microcapsules or copolymer micelles.

Abstract: An improved intraocular lens is coated with a non-smudging biologically compatible hydrophobic crosslinked vinyl-containing silicone polymer coating material, such as polymethylvinyl siloxane or polymethylphenylvinyl siloxane. The coating material is inert, does not smudge upon contact with another surface, reduces damage on contact with the intraocular tissue, particularly the endothelium, and prevents intraocular lens induction of inflammation. The coating material or matrix preferably contains at least one optically compatible medicament which can be gradually and controllably released therefrom with time and which makes the lens suitable for implantation in both the phakic and aphakic eye. The coating material may further contain a small amount of fine particle size fumed silica.

Abstract: The fixation of an intraocular lens is aided by instilling into an eye having an intraocular lens about one drop of an ophthalmic solution containing an .alpha.-adrenergic blocking agent, such as thymoxamine, in a concentration of from about 0.1% to about 1% by weight, preferably about 0.5% by weight.

Abstract: Intraocular lenses are terminally sterilized without any significant chemical change in the surface of the lenses by placing the intraocular lenses in a 5% to 10% sodium hydroxide solution for from 24 hours to 3 hours, respectively, and storing the intraocular lenses in the same solution until they are used.

Abstract: An intraocular lens is coated with a compatible medicament, such as an anticoagulant, an anti-inflammatory agent or an anti-complement agent.