Abstract: The invention relates to determining electronic text communication distributed in bulk is likely solicited. In one step, a first electronic and a second electronic submission are received. It is determined that the first electronic submission is likely solicited. A first portion is extracted from the first electronic submission and a second portion from the second electronic submission. The content of the first electronic submission influences extraction of the first portion, and the content of the second electronic submission influences extraction of the second portion. A first code is determined for the first portion and a second code is determined for the second portion, where the first code is indicative of the first portion and the second code is indicative of the second portion. The first code is compared to the second code. It is determined that the second electronic submission is likely solicited, at least in part, in response to comparing the first code to the second code.

Abstract: A formulation for non-invasive delivery of pharmaceutical agents, particularly proteins and peptides, by absorption through a membrane at a targeted site is provided, along with a process of making the formulation. The formulation comprises a suspension of solid-phase dehydrated particles in a delivery medium. The particles comprise the dehydration product of the pharmaceutical agent and at least one of a surfactant and permeation enhancer, and the delivery medium preferably comprises a propellant for pressurized aerosol delivery of the formulation. The formulation can be conveniently delivered to the patient's targeted site where the pharmaceutical agent is absorbed through the mucosa to achieve a desired bioavailability.

Abstract: The present invention provides a non-invasive method for administering polypeptides across epithelial membranes. The formulations in the present invention comprise solid polypeptide particles mixed with a permeation enhancer and excipients which are dispersed in a media for oral or intranasal administration. Also provided in the present invention is a process to prepare the formulations.